Search results for "8-oxo-dG"

showing 4 items of 4 documents

Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis

2012

Monoclonal B Lymphocytosis (MBL) is defined as asymptomatic monoclonal B-cell expansion characterised by a CLL-phenotype, but with less than 5 x 10(9)/I circulating cells. Reactive oxygen species (ROS)-mediated cell damage plays a critical role in the initiation of carcinogenesis as well as in malignant transformation. The goal of this study was to perform an analysis of the oxidative stress statuses of patients affected by MBL and chronic lymphocytic leukaemia (CLL). We examined peripheral blood and urine specimens from 29 patients with MBL, 55 with CLL and 31 healthy subjects. There was a significant increase in the occurrence of the mutagenic base 8-oxo-2'-deoxiguanosine (8-oxo-dG) in th…

8-Oxo-dGMaleChronic lymphocytic leukaemiaCancer ResearchF-2-isoprostanesTime FactorsLymphocytosisDNA damageLymphocytosisBiologyDinoprostmedicine.disease_causeAntioxidantsLipid peroxidationchemistry.chemical_compoundMalondialdehydemedicineHumansCell damageChromatography High Pressure LiquidAgedchemistry.chemical_classificationB-LymphocytesReactive oxygen speciesGlutathione DisulfideDeoxyguanosineMonoclonal B LymphocytosisGlutathioneMiddle AgedMalondialdehydemedicine.diseaseGlutathioneLeukemia Lymphocytic Chronic B-CellOxidative StressOncologychemistryOxidative stress8-Hydroxy-2'-DeoxyguanosineImmunologyDNA damageFemalemedicine.symptomReactive Oxygen SpeciesBiomarkersOxidative stressDNA DamageCancer Letters
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Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker

2013

We characterized the oxidative stress (OS) status by the levels of reduced/oxidized glutathione (GSH/GSSG), malondialdehyde (MDA) and the mutagenic base 8-oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) in human gastric carcinoma (HGC) samples and compared the results with normal tissue from the same patients. We also analyzed 8-oxo-dG in peripheral mononuclear cells (PMNC) and urine from healthy control subjects and in affected patients in the basal state and one, three, six, nine and twelve months after tumor resection. The levels of DNA repair enzyme mRNA expression (hOGG1, RAD51, MUYTH and MTH1) were determined in tumor specimens and compared with normal mucosa. Tumor specimens e…

lcsh:ChemistryDNA repair enzymeslcsh:Biology (General)lcsh:QD1-999gastric cancertumor markeroxidative stress8-oxo-dGlcsh:QH301-705.5International Journal of Molecular Sciences
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Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker

2013

We characterized the oxidative stress (OS) status by the levels of reduced/oxidized glutathione (GSH/GSSG), malondialdehyde (MDA) and the mutagenic base 8-oxo-7′8-dihydro-2′-deoxyguanosine (8-oxo-dG) in human gastric carcinoma (HGC) samples and compared the results with normal tissue from the same patients. We also analyzed 8-oxo-dG in peripheral mononuclear cells (PMNC) and urine from healthy control subjects and in affected patients in the basal state and one, three, six, nine and twelve months after tumor resection. The levels of DNA repair enzyme mRNA expression (hOGG1, RAD51, MUYTH and MTH1) were determined in tumor specimens and compared with normal mucosa. Tumor specimens exhibited i…

medicine.medical_specialtyPathologyDNA damageDNA repair8-oxo-dGBiologymedicine.disease_causePeripheral blood mononuclear cellArticleCatalysisInorganic Chemistrychemistry.chemical_compoundInternal medicinemedicine8-oxo-dG; DNA repair enzymes; gastric cancer; oxidative stress; tumor markeroxidative stressDeoxyguanosinePhysical and Theoretical ChemistryMolecular BiologySpectroscopyTumor markergastric cancerOrganic ChemistryGeneral MedicineGlutathioneMalondialdehydeComputer Science ApplicationsEndocrinologyDNA repair enzymeschemistrytumor markerOxidative stressInternational Journal of Molecular Sciences; Volume 14; Issue 2; Pages: 3467-3486
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The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women

2018

This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women. Methods: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands. Thiol redox state was determined by reduced glutathione (GSH), oxidized glu…

urine 8-oxo-dGrandomized controlled trialstrength trainingGSHoxidative stressGSSG
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