Search results for "80"

showing 10 items of 13972 documents

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

2018

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…

p53MaleCancer ResearchCellTranscriptome0302 clinical medicineHCCbeta CateninAged 80 and overLuminespibAUY922Liver NeoplasmsHep G2 CellsSorafenibMiddle AgedUp-RegulationGene Expression Regulation Neoplasticmedicine.anatomical_structureOncologyCaspases030220 oncology & carcinogenesisHepatocellular carcinomaFemaleNUPR1medicine.drugAdultSorafenibCarcinoma Hepatocellularβ-CateninMice NudeAntineoplastic AgentsSmall Molecule Libraries03 medical and health sciencesDownregulation and upregulationIn vivoCell Line TumormedicineHSP90AnimalsHumansHSP90 Heat-Shock ProteinsAgedCell growthbusiness.industryMcl-1IsoxazolesResorcinolsHCCSmedicine.diseasedigestive system diseasesMutationCancer researchTranscriptomebusinessInternational Journal of Cancer
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"Table 6" of "$\rm{K}^{*}(\rm{892})^{0}$ and $\phi(1020)$ production at midrapidity in pp collisions at $\sqrt{s}$ = 8 TeV"

2020

No table description available.

pT differential ratio 7TeV to 2.76TeV for Kstar1/Nev d^2N/(dp_Tdy) (GeV/c)^{-1}7000.0-8000.0
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"Table 8" of "$\rm{K}^{*}(\rm{892})^{0}$ and $\phi(1020)$ production at midrapidity in pp collisions at $\sqrt{s}$ = 8 TeV"

2020

No table description available.

pT differential ratio 7TeV to 2.76TeV for Phi1/Nev d^2N/(dp_Tdy) (GeV/c)^{-1}7000.0-8000.0
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"Table 5" of "$\rm{K}^{*}(\rm{892})^{0}$ and $\phi(1020)$ production at midrapidity in pp collisions at $\sqrt{s}$ = 8 TeV"

2020

No table description available.

pT differential ratio 8TeV to 2.76TeV for Kstar1/Nev d^2N/(dp_Tdy) (GeV/c)^{-1}7000.0-8000.0
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Persoonallisuuden merkitys työmarkkinoilla

2012

palkkatulotlcsh:HD4801-8943Katsauksia ja keskusteluaKatsauksia & keskustelualcsh:Labor. Work. Working classlcsh:Businesstyöttömyyslcsh:HF5001-6182persoonallisuus
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Säröt hyvinvointityön kertomuksessa

2014

palvelutlcsh:HD4801-8943hyvinvointilcsh:Labor. Work. Working classtyöelämälcsh:Businesslcsh:HF5001-6182LektiotTyöelämän tutkimus
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Effects of satellite transmitters on survival in Snowy Owls Bubo scandiacus

2017

The use of tracking devices to monitor birds is extensive, but the effects of such instruments on equipped individuals are still insufficiently taken into account. Here we evaluate potential effects of backpack-mounted satellite transmitters (platform terminal transmitters; PTTs) on survival of 28 Snowy Owls Bubo scandiacus. Six confirmed deaths were all probably related to natural and human-induced causes. Although PTT operational time was significantly shorter than expected lifetime of Snowy Owls, five owls were observed alive after transmissions ceased. Additionally four PTTs stopped due to low battery levels, indicating end of transmitter life and not owl mortality. We found no evidence…

parasitic diseases:Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480 [VDP]psychological phenomena and processes
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MILKER’S NODULE. A PERPLEXING FARMYARD INFECTION AND THREAT TO THE IMMUNOCOMPROMISED

2017

Milker’s nodules, also called paravaccinia, is a DNA virus transmitted from infected cows to humans. It results from contact with cattle, cattle byproducts, or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers, and agricultural tourists. The viral infection begins 5—15 days after inoculation as an erythematous-purple, round nodule with a clear depressed center, and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed. Milker’s nodules are selflimited in immunocompetent individuals and heal without scarring within 8 weeks. An…

paravacciniaoccupational infectionmilker’s noduleDiseaseVirusparapoxviruszoonotic diseasegraft-versus-host diseaselcsh:Dermatologymedicineanimal to humanErythema multiformehematopoietic stem cell transplantorfimmunosuppressedpsuedocowpoxvirusbiologybusiness.industryerythema multiformeCancerNodule (medicine)lcsh:RL1-803farmyard poxmedicine.diseasebiology.organism_classificationVirologyGraft-versus-host diseasepoxvirusParapoxvirusMilker's nodulemedicine.symptombusinessVestnik dermatologii i venerologii
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Om dere vil høre hvordan jeg har det? : en litteraturstudie som omhandler barns opplevelse av alvorlige foreldrekonflikter og hva som kan bidra til å…

2016

Masteroppgave psykisk helsearbeid ME504 - Universitetet i Agder 2016 The purpose of this thesis is to convey knowledge about how children experience serious parental conflicts and how to decrease the negative impact these conflicts has on the children involved. A literature review has been chosen as the scientific method while working with this study. A comprehensive search in different scientific databases has been performed, in a process in which English words have been used. This study is an integrative review where a combination of different approaches allow me to summarize empirical and theoretical literature into comprehensive knowledge about a phenomenon. The theoretical perspectives…

parental conflictME504VDP::Medisinske Fag: 700::Helsefag: 800skilsmisseattachment behaviorVDP::Samfunnsvitenskap: 200::Psykologi: 260family therapydivorceparent-child relationschildrens experiences
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Parenting Dimensions and Adolescent Peer Aggression: A Gendered Analysis

2020

The present study had two main goals. The first was to analyze the differences between parenting dimensions&mdash

parental involvementmedia_common.quotation_subjectGeography Planning and DevelopmenteducationTJ807-830050109 social psychologyManagement Monitoring Policy and LawTD194-195Renewable energy sourcesDevelopmental psychologymedicinegenderGE1-3500501 psychology and cognitive sciencesGirlVíctimesmedia_commonRol de paresEnvironmental effects of industries and plantsparental impositionRenewable Energy Sustainability and the EnvironmentAggression05 social sciencesparenting dimensionsEnvironmental sciencesaggressive victimsmedicine.symptomAgressivitatpeer aggressionPsychology050104 developmental & child psychologySustainability
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