Search results for "83"

Introduction Particularly in the setting of acute coronary syndromes, the interplay between vascular and platelet function has been postulated to have direct clinical implications. The present trial is designed to test the effect of clopidogrel, prasugrel and ticagrelor on multiple parameters of vascular function, platelet aggregation, oxidative and inflammatory stress before and up to 4 weeks after coronary artery stenting. Methods and analysis The study is designed as a three-arm, parallel design, randomised, investigator-blinded study. Patients with unstable angina or non-ST elevation myocardial infarction undergoing coronary intervention with a drug-eluting stent will be randomised to r…

1683AdultBlood PlateletsMaleTicagrelorAdenosineTiclopidineAdolescent610 MedizinCardiovascular MedicineYoung AdultPercutaneous Coronary Intervention610 Medical sciencesProtocolHumansSingle-Blind Method1506Prospective StudiesAcute Coronary Syndrome1707AgedDrug-Eluting StentsMiddle AgedClopidogrelOxidative StressTreatment OutcomePurinergic P2Y Receptor AntagonistsFemaleEndothelium VascularPrasugrel HydrochloridePlatelet Aggregation InhibitorsFollow-Up Studies

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Population-based cohort study of warfarin-treated patients with atrial fibrillation: incidence of cardiovascular and bleeding outcomes

2014

OBJECTIVES: Atrial fibrillation (AF) is the most common cardiac rhythm disorder with a significant health burden. The aim of this study was to characterise patients with recently diagnosed AF and to estimate the rates of comorbidities and outcome events requiring hospitalisation in routine clinical practice. DESIGN: Pharmacoepidemiological cohort study using observational data. METHODS/SETTING: This study included 16 513 patients with a first diagnosis of AF between 1 January 2005 and 28 February 2010 (newly diagnosed patients) using data from the UK Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and the Office for National Statistics mortality data. …

1683AdultMalemedicine.medical_specialtyPediatricsmedicine.drug_classPopulationCardiologyHemorrhageCardiovascular MedicineCohort StudiesYoung AdultAtrial FibrillationEpidemiologymedicine1724Humans1506educationStrokeAgedAged 80 and overeducation.field_of_studybusiness.industryResearchIncidenceIncidence (epidemiology)WarfarinAnticoagulantsThrombosisGeneral MedicineMiddle AgedVitamin K antagonistmedicine.disease1692Cardiovascular DiseasesEmergency medicineFemaleWarfarinDiagnosis codebusinessCohort studymedicine.drug

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Impact of immunodepression and moderate alcohol consumption on coronary and other arterial disease events in an 11-year cohort of HIV-infected patien…

2012

Objective To investigate the relationship between response to antiretroviral therapy (ART), alcohol use and occurrence of a major coronary or other arterial disease event (CADE) in HIV-infected individuals. Design A cohort study. A Cox model was used to identify the correlates of a first occurrence of a major CADE. Setting The French ANRS CO8 APROCO-COPILOTE cohort was set up in 1997 to study clinical progression and patient-reported outcomes (PRO) after initiating a protease inhibitor-containing ART. Clinical data were retrieved from medical records. Self-administered questionnaires collected data on PRO and behaviours, including alcohol use. Participants Metabolic data were only available…

1683Pathologymedicine.medical_specialtyArterial disease03 medical and health sciences0302 clinical medicineAcquired immunodeficiency syndrome (AIDS)Internal medicinemedicineHiv infected patients1506030212 general & internal medicine17060303 health sciences030306 microbiologyProportional hazards modelbusiness.industryResearchGeneral Medicinemedicine.diseaseAntiretroviral therapy3. Good healthInfectious DiseasesCohort1714businessAlcohol consumptionCohort studyBMJ Open

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