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The potential of serum neurofilament as biomarker for multiple sclerosis

2021

Abstract Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal damage as well as its quantification is a critical step for patients. Blood-based serum neurofilament light chain (sNfL) is currently under close investigation as an easily accessible biomarker of prognosis and treatment response in patients with multiple sclerosis. There is abundant evidence that sNfL levels reflect ongoing inflammatory-driven neuroaxonal damage (e.g. relapses or MRI disease activity) and that sNfL levels predict disease activity over the next few years. In contrast, the association of sNfL with long-term clinical outcomes or its ability to reflect slow, diffuse neurodegenerativ…

Oncologymedicine.medical_specialtyTreatment responseMultiple SclerosisNeurofilamentFilaments citoplasmàticsDiseaseneurofilamentUpdatesNeurofilament ProteinsInternal medicinemedicineHumans:aminoácidos péptidos y proteínas::proteínas::aminoácidos péptidos y proteínas::proteínas::proteínas del tejido nervioso::proteínas de neurofilamentos [COMPUESTOS QUÍMICOS Y DROGAS]Longitudinal StudiesSubclinical disease:Diagnosis::Prognosis [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Esclerosi múltiple - Imatgeria per ressonància magnètica:diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]:Other subheadings::Other subheadings::/diagnostic imaging [Other subheadings]AcademicSubjects/SCI01870business.industrytherapy responseMultiple sclerosis:Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases CNS::Multiple Sclerosis [DISEASES]biomarkers:Otros calificadores::Otros calificadores::/diagnóstico por imagen [Otros calificadores]:Amino Acids Peptides and Proteins::Proteins::Amino Acids Peptides and Proteins::Proteins::Nerve Tissue Proteins::Neurofilament Proteins [CHEMICALS AND DRUGS]Prognosismedicine.diseaseEsclerosi múltiple - PrognosiMagnetic Resonance ImagingClinical trialEarly results:enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES]Biomarker (medicine)AcademicSubjects/MED00310Neurology (clinical)businessBrain
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"Table 14" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

The decoupling time extracted from R_long(KT) as a function of the central charged multiplicity. Data from other experiments is shown for comparison.

PB PB --> PI- PI- XInclusive2.7-2760.0PB PB --> PI+ PI+ X29688702968870TIME
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"Table 4" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Projections of the correlation function C.

PB PB --> PI- PI- XInclusive2760.0CORR29688702968870
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"Table 5" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Projections of the correlation function C.

PB PB --> PI- PI- XInclusive2760.0CORR29688702968870
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"Table 7" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Projections of the correlation function C.

PB PB --> PI- PI- XInclusive2760.0CORR29688702968870
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"Table 6" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Projections of the correlation function C.

PB PB --> PI- PI- XInclusive2760.0CORR29688702968870
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"Table 1" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Projections of the correlation function C.

PB PB --> PI- PI- XInclusive2760.0CORR29688702968870
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"Table 2" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Projections of the correlation function C.

PB PB --> PI- PI- XInclusive2760.0CORR29688702968870
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"Table 3" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Projections of the correlation function C.

PB PB --> PI- PI- XInclusive2760.0CORR29688702968870
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"Table 13" of "Two-pion Bose-Einstein correlations in central PbPb collisions at sqrt(s_NN) = 2.76 TeV"

2011

Product of the three HBT radii at KT=0.3 for the 5% most central collisions as a function of the central charged multiplicity. Data from other experiments is shown for comparison.

PB PB --> PI- PI- XInclusiveRADIUS2.7-2760.0PB PB --> PI+ PI+ X29688702968870
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