Search results for "8H"

showing 10 items of 10 documents

The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells.

2018

PTPRJ, a receptor protein tyrosine phosphatase strongly downregulated in human cancer, displays tumor suppressor activity by negatively modulating several proteins involved in proliferating signals. Here, through a proteomic-based approach, we identified a list of potential PTPRJ-interacting proteins and among them we focused on CD98hc, a type II glycosylated integral membrane protein encoded by SLC3A2, corresponding to the heavy chain of a heterodimeric transmembrane amino-acid transporter, including LAT1. CD98hc is widely overexpressed in several types of cancers and contributes to the process of tumorigenesis by interfering with cell proliferation, adhesion, and migration. We first valid…

0301 basic medicineCD98hcChemistryCell growthCellPTPRJProtein tyrosine phosphatasemedicine.disease_causeProtein tyrosine phosphatase03 medical and health scienceschemistry.chemical_compound030104 developmental biologymedicine.anatomical_structureProteasomal degradationOncologyMG132Cancer cellCancer researchmedicineProteasome inhibitorGene silencingLung cancerCarcinogenesismedicine.drugResearch Paper
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New Tripentone Analogs with Antiproliferative Activity

2017

Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar range. New tripentone analogs, in which a pyridine moiety replaces the thiophene ring originating the fused azaindole system endowed with anticancer activity viz 8H-thieno[2,3-b]pyrrolizinones, were efficiently synthesized in four steps with fair overall yields (34–57%). All tripentone derivatives were tested in the range of 0.1–100 μM for cytotoxicity against two human tumor cell lines, HCT-116 (human colorectal carcinoma) and MCF-7 (human breast cancer). The most active derivative, with GI50 values of 4.25 µM and 20.73 µM for HCT-116 a…

8H-thieno[23-b]pyrrolizinonePyridinesPharmaceutical SciencetripentonesApoptosis01 natural sciencesAnalytical Chemistrychemistry.chemical_compoundDrug DiscoveryThiopheneCytotoxic T cellCytotoxicityMolecular StructureCell Cycletripentoneproapoptotic agentsCell cycleBiochemistryChemistry (miscellaneous)MCF-7 CellsMolecular Medicineaza-indolesAntineoplastic Agents010402 general chemistryArticlelcsh:QD241-441Structure-Activity Relationshiplcsh:Organic chemistryCell Line TumormedicineHumansantitumor activityPhysical and Theoretical ChemistryMode of actionCell ProliferationDose-Response Relationship Drug010405 organic chemistryOrganic ChemistryCancermedicine.diseaseHCT116 CellsSettore CHIM/08 - Chimica Farmaceutica0104 chemical sciences8H-thieno[23-b]pyrrolizinoneschemistryApoptosisCell cultureaza-indoletripentones; aza-indoles; 8<i>H</i>-thieno[23-<i>b</i>]pyrrolizinones; antitumor activity; proapoptotic agentsCaco-2 CellsMolecules; Volume 22; Issue 11; Pages: 2005
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CCDC 2092211: Experimental Crystal Structure Determination

2021

Related Article: Samantha A. Murphy, Caroline Phelan, Sankarasekaran Shanmugaraju, Salvador Blasco, Thorfinnur Gunnlaugsson|2021|Tetrahedron Lett.|83|153405|doi:10.1016/j.tetlet.2021.153405

Space GroupCrystallographyCrystal SystemCrystal Structure514-bis[2-(piperidin-1-yl)ethyl]-817-methanobenzo[de]benzo[4'5']isoquinolino[7'6':67][15]diazocino[32-g]isoquinoline-461315(5H9H14H18H)-tetrone methanol solvateCell ParametersExperimental 3D Coordinates
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CCDC 1412268: Experimental Crystal Structure Determination

2017

Related Article: Daniel Stubba, Günther Lahm, Mario Geffe, Jason W. Runyon, Anthony J. Arduengo III, Till Opatz|2015|Angew.Chem.,Int.Ed.|54|14187|doi:10.1002/anie.201508500

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters22'33'1010'1111'-octamethoxy-55'66'-tetrahydro-8H8'H-1313'-biisoquinolino[32-a]isoquinoline-88'-dione chloroform solvateExperimental 3D Coordinates
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CCDC 269375: Experimental Crystal Structure Determination

2005

Related Article: C.Peifer, D.Schollmeyer, G.Dannhardt|2005|Acta Crystallogr.,Sect.E:Struct.Rep.Online|61|o724|doi:10.1107/S160053680500485X

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters567-Trimethoxy-23-dihydro-1H8H-benzo(a)pyrrolo(34-c)carbazole-13-dione dimethyl sulfoxide solvateExperimental 3D Coordinates
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CCDC 1899383: Experimental Crystal Structure Determination

2019

Related Article: Fernando Rabasa-Alcañiz, Daniel Hammerl, Anabel Sánchez-Merino, Tomás Tejero, Pedro Merino, Santos Fustero, Carlos del Pozo|2019|Org.Chem.Front.|6|2916|doi:10.1039/C9QO00525K

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters7-(trifluoromethyl)-6a77a1014b15a-hexahydro-6H8H9aH-[1]benzopyrano[3'4':45]pyrrolo[12-d]indeno[21-b][14]oxazin-8-oneExperimental 3D Coordinates
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CCDC 1834566: Experimental Crystal Structure Determination

2018

Related Article: Serhii Krykun, Vincent Croué, Magali Allain, Zoia Voitenko, Juan Aragó, Enrique Ortí, Sébastien Goeb, Marc Sallé|2018|J.Mater.Chem.C|6|13190|doi:10.1039/C8TC04730H

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters8-[45-bis(methylsulfanyl)-2H-13-dithiol-2-ylidene]benzo[12-b:45-b']bisthiophen-4(8H)-oneExperimental 3D Coordinates
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CCDC 679819: Experimental Crystal Structure Determination

2008

Related Article: C.Bonnot, J.-C.Chambron, E.Espinosa, R.Graff|2008|J.Org.Chem.|73|868|doi:10.1021/jo701984z

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates2111726-tetra-t-butyl-32363943-tetra-p-tosyl-67141521222930-octahydro-13H28H-49:1924-di(methanoiminopropanoiminomethano)tetrabenzo[ejpu][141215819]tetrathiadiazacyclodocosine-1429-diium bis(trifluoroacetate) dichloromethane solvate
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CCDC 1564490: Experimental Crystal Structure Determination

2017

Related Article: Fernando Rabasa-Alcañiz, Javier Torres, María Sánchez-Roselló, Tomás Tejero, Pedro Merino, Santos Fustero, Carlos del Pozo|2017|Adv.Synth.Catal.|359|3752|doi:10.1002/adsc.201700975

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates3-methyl-5-(nitromethyl)-10b-(trifluoromethyl)-133a4510b-hexahydro-8H-[13]dioxolo[67]naphtho[21-c][12]oxazole
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CCDC 1913564: Experimental Crystal Structure Determination

2019

Related Article: Samuel M. Meier-Menches, Brech Aikman, Daniel Döllerer, Wim T. Klooster, Simon J. Coles, Nicolò Santi, Louis Luk, Angela Casini, Riccardo Bonsignore|2020|J.Inorg.Biochem.|202|110844|doi:10.1016/j.jinorgbio.2019.110844

Space GroupCrystallographyCrystal System[(pyridin-4-yl)ethynyl]-(1379-tetramethyl-26-dioxo-123679-hexahydro-8H-purin-8-ylidene)-gold(i) unknown solvateCrystal StructureCell ParametersExperimental 3D Coordinates
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