Search results for "8M"

showing 2 items of 12 documents

Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.

2005

Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …

p38 mitogen-activated protein kinasesMAP Kinase Kinase 3Mice TransgenicMAP Kinase Kinase 6BiologyMAP Kinase Kinase Kinase 5p38 Mitogen-Activated Protein KinasesReceptors Tumor Necrosis FactorCellular and Molecular NeuroscienceMiceSuperoxide Dismutase-1Downregulation and upregulationAnimalsHumansASK1RNA Messengerfas ReceptorPhosphorylationReceptorProtein kinase AMolecular BiologyP38MAPK cascadeMotor NeuronsKinaseSuperoxide DismutaseTumor Necrosis Factor-alphaAmyotrophic Lateral SclerosisJNK Mitogen-Activated Protein KinasesReceptors Interleukin-1Cell BiologyCell biologyEnzyme ActivationMice Inbred C57BLDisease Models AnimalTumor Necrosis Factor Decoy ReceptorsSpinal CordReceptors Tumor Necrosis Factor Type IDisease ProgressionTumor necrosis factor alphaSignal TransductionMolecular and cellular neurosciences
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Cybersecurity Attacks on Software Logic and Error Handling Within ADS-B Implementations: Systematic Testing of Resilience and Countermeasures

2022

Automatic Dependent Surveillance-Broadcast (ADS-B) is a cornerstone of the next-generation digital sky and is now mandated in several countries. However, there have been many reports of serious security vulnerabilities in the ADS-B architecture. In this paper, we demonstrate and evaluate the impact of multiple cyberattacks on ADS-B via remote radio frequency links that affected various network, processing, and display subsystems used within the ADS-B ecosystem. Overall we implemented and tested 12 cyberattacks on ADS-B in a controlled environment, out of which 5 attacks were presented or implemented for the first time. For all these attacks, we developed a unique testbed that consisted of 1…

vulnerabilitiesATCcybersecurity1090MHzlentoliikenneAerospace Engineeringcountermeasuresavionics978MHzdatalinkATMpentestingaviationexperimental platformElectrical and Electronic EngineeringUATlennonjohtoEFBkyberturvallisuusverkkohyökkäyksetlennonvarmistusADS-B1090ESIEEE Transactions on Aerospace and Electronic Systems
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