Search results for "8b"

showing 10 items of 62 documents

CCDC 295280: Experimental Crystal Structure Determination

2006

Related Article: E.Schweizer, A.Hoffmann-Roder, K.Scharer, J.A.Olsen, C.Fah, P.Seiler, U.Obst-Sander, B.Wagner, M.Kansy, F.Diederich|2006|ChemMedChem|1|611|doi:10.1002/cmdc.200600015

Space GroupCrystallographyCrystal SystemCrystal Structure(+)-(3aS4R8S8aR8bR)-4-(4-bromophenyl)-2-(4-fluorobenzyl)-8-hydroxy-13-dioxodecahydropyrrolo[34-a]pyrrolizineCell ParametersExperimental 3D Coordinates
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CCDC 295281: Experimental Crystal Structure Determination

2006

Related Article: E.Schweizer, A.Hoffmann-Roder, K.Scharer, J.A.Olsen, C.Fah, P.Seiler, U.Obst-Sander, B.Wagner, M.Kansy, F.Diederich|2006|ChemMedChem|1|611|doi:10.1002/cmdc.200600015

Space GroupCrystallographyCrystal SystemCrystal Structure(+)-4-((3aS4R8aR8bR)-2-(4-fluorobenzyl)-88-difluoro-13-dioxodecahydropyrrolo[34-a]pyrrolizin-4-yl)benzonitrileCell ParametersExperimental 3D Coordinates
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CCDC 607536: Experimental Crystal Structure Determination

2007

Related Article: A.Hoffmann-Roder, E.Schweizer, J.Egger, P.Seiler, U.Obst-Sander, B.Wagner, M.Kansy, D.W.Banner, F.Diederich|2006|ChemMedChem|1|1205|doi:10.1002/cmdc.200600124

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(+-)-4-((1SR3aSR4RS8aSR8bRS)-1-Fluoro-2-(4-fluorobenzyl)-3-oxo-1-(trifluoromethyl)decahydropyrrolo(34-a)pyrrolizin-4-yl)benzonitrileExperimental 3D Coordinates
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CCDC 830704: Experimental Crystal Structure Determination

2016

Related Article: Hanene Jelizi, Nadia Wannassi, Mohamed El Baker Rammah, Kabula Ciamala, Michael Knorr, Yoann Rousselin, Marek M. Kubicki, Carsten Strohmann and Mironel Enescu|2014|J.Heterocycl.Chem.|51|383|doi:10.1002/jhet.1588

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-(4-methoxyphenyl)-4-phenyl-8b-(pyrrolidin-1-yl)-48b-dihydro-3aH-indeno[21-d][12]oxazoleExperimental 3D Coordinates
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CCDC 295279: Experimental Crystal Structure Determination

2006

Related Article: E.Schweizer, A.Hoffmann-Roder, K.Scharer, J.A.Olsen, C.Fah, P.Seiler, U.Obst-Sander, B.Wagner, M.Kansy, F.Diederich|2006|ChemMedChem|1|611|doi:10.1002/cmdc.200600015

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates(+)-4-((3aS4R7S8aS8bR)-2-(4-fluorobenzyl)-7-fluoro-13-dioxodecahydropyrrolo[34-a]pyrrolizin-4-yl)benzonitrile
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CCDC 831070: Experimental Crystal Structure Determination

2014

Related Article: Hanene Jelizi, Nadia Wannassi, Mohamed El Baker Rammah, Kabula Ciamala, Michael Knorr, Yoann Rousselin, Marek M. Kubicki, Carsten Strohmann and Mironel Enescu|2014|J.Heterocycl.Chem.|51|383|doi:10.1002/jhet.1588

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates4-Methyl-3-(4-methylphenyl)-8b-(morpholin-4-yl)-48b-dihydro-3aH-indeno[21-d][12]oxazole
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CCDC 297366: Experimental Crystal Structure Determination

2006

Related Article: E.Schweizer, A.Hoffmann-Roder, J.A.Olsen, P.Seiler, U.Obst-Sander, B.Wagner, M.Kansy, D.W.Banner, F.Diederich|2006|Org.Biomol.Chem.|4|2364|doi:10.1039/b602585d

Space GroupCrystallographyCrystal Systemrac-(1S3aS4R8aS8bR)/(1R3aR4S8aR8bS)-4-(4-Bromophenyl)-2-((4-fluorophenyl)methyl)-1-hydroxyoctahydrodipyrrolo(12-a:3'4'-c)pyrrol-3(2H)-oneCrystal StructureCell ParametersExperimental 3D Coordinates
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IL28B CC GENOTYPE IS ASSOCIATED WITH HIGHER ON-TREATMENT-RESPONSE RATES IN PTS WITH HCV-3: INTERIM RESULTS OF THE WRITE STUDY

2012

TreatmentPeg-InterferonGenotypeIL28B CCIL28B CC; HCV-3; Peg-InterferonWrite StudyChronic Hepatitic CHCV-3
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IL28B and PNPLA3 Polymorphisms Affect Histological Liver Damage in Patients with Non-alcoholic Fatty Liver Disease.

2012

Background & Aims: Genetic background may affect liver damage in patients with non-alcoholic fatty liver disease (NAFLD). The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients. Methods: One hundred sixty consecutive NAFLD patients were assessed by liver biopsy (Kleiner score); anthropometric, and biochemical and metabolic features were included. IL28B rs12979860 C>T, IL28B rs8099917 G>C, and PNPLA3 rs738409 C>G single nucleotide polymorphisms were tested. Results: Seventy-four (46.2%) patients had IL28B rs12979860 CC polymorph…

Univariate analysismedicine.medical_specialtyPathologySettore MED/12 - GastroenterologiaHepatologymedicine.diagnostic_testFatty liverliver fibrosiSingle-nucleotide polymorphismBiologySettore MED/08 - Anatomia Patologicamedicine.diseaseGastroenterologynonalcoholic fatty liver IL28B PNPLA3 PolymorphismsInterleukin 28BFibrosisInternal medicineLiver biopsyGenotypemedicinenafld liver biopsyHyperuricemia
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Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.

2012

BACKGROUND: Genotype 1 (G1) chronic hepatitis C (CHC) patients achieving a rapid virological response (RVR) on pegylated interferon (PEG-IFN) plus ribavirin have a high chance of sustained virological response (SVR), influenced by IL28B status, viral load, fibrosis and insulin resistance. We assessed whether 25-hydroxyvitamin D (25[OH]D) serum levels are linked to RVR and can be used together with IL28B to construct a pretreatment model to predict RVR. METHODS: A total of 117 consecutive patients with G1 CHC were evaluated by biopsy and anthropometric and metabolic measurements. 25(OH)D serum levels were measured by HPLC. IL28B rs12979860 and rs8099917 polymorphisms were also evaluated. All…

Vitamin DIL28B chronic hepatitis C
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