Search results for "9(26)"
showing 3 items of 23 documents
Regulation of physiological differentiation in Nonomuraea sp. ATCC 39727
2014
The Actinomycete Nonomuraea produces the glycopeptide A40926, precursor of dalbavancin, a novel lipoglycopeptide homologous to vancomycin that could be used against emerging resistant Gram-positive bacteria. The A40926 biosynthetic gene cluster (dbv), which consists of 37 genes, encodes two regulators, Dbv3 (LuxR-like) and Dbv4 (StrR-like), as well as the response regulator (Dbv6) and the sensor-kinase (Dbv22) of a putative two-component system. Previous work demonstrated a positive role of Dbv4 in antibiotic production by activating the transcription of 13 dbv genes; up to now no role was assigned to Dbv3, Dbv6 and Dbv22. In addition, an IclR-like protein is thought to be involved in dbv4 …
Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm
2014
Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…
Sisäistyneet ristiriidat, tunnetyö ja tietotyöläissubjektiviteetin rakentuminen
2015
Yliopistotyö on esimerkki uuden työn muodoista, joissa työ kiinnittyy aiempaa vahvemmin yksilöön. Samalla vastuu työelämän vaatimuksiin yltämisestä siirtyy työntekijälle itselleen. Työyhteisön ristiriitatilanteissa organisaation ongelmat sisäistyvät työntekijän yksityisiksi ja tunne-elämän ongelmiksi.