Search results for "93"
showing 10 items of 1707 documents
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
2008
The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
2014
Activating mutations in genes encoding phosphatidylinositol 3-kinase (PI3K)-AKT pathway components cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH, OMIM 603387)(1-3). Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 313 (GSK-3 beta)(4). Mutant CCND2 was resistant to proteasomal degradation in vitro compared to wild-type CCND2. The PI3K-AKT pathway modulates GSK-3 beta activity(4), and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation. CCND…
Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17
2014
Melatonin controls many physiological functions including regulation of the circadian rhythm and clearance of free radicals and neuroprotection. Importantly, melatonin levels strongly decrease as we age and patients with Alzheimer's disease (AD) display lower melatonin than age-matched controls. Several studies have reported that melatonin can reduce aggregation and toxicity of amyloid-β peptides that are produced from the β-amyloid precursor protein (βAPP). However, whether melatonin can directly regulate the βAPP-cleaving proteases ('secretases') has not been investigated so far. In this study, we establish that melatonin stimulates the α-secretase cleavage of βAPP in cultured neuronal an…
A New Mutation in the Promoter Region of the PAX8 Gene Causes True Congenital Hypothyroidism with Thyroid Hypoplasia in a Girl with Down's Syndrome
2014
Thyroid dysfunction is common in newborn infants with Down's syndrome (DS), but defects causing classic thyroid dysgenesis (TD) with permanent congenital hypothyroidism (CH) have not been described.We studied a girl with DS and CH who had a mutation in the promoter sequence of the PAX8 gene.A female infant was found to have trisomy 21 and CH, with a venous thyrotropin (TSH) of150 mU/L and a free thyroxine (fT4) of 15.1 pmol/L (day 12). Thyroid peroxidase antibodies and thyroglobulin antibodies were elevated. Scintigraphy showed normal uptake, but ultrasound identified a small gland with heterogenous echotexture and cystic changes. Sequence analysis of the PAX8 gene revealed a new heterozygo…
Les enjeux politiques et pédagogiques de l'illustration pour enfants en URSS dans les années 1920-1930
2016
International audience
L’ampliamento come occasione di recupero della memoria e dell’identità
2012
We present the enlargement plan of an isolated cemetery in a small town of the west Sicily as it exemplifies some way to carry out the design for an “addition”. The enlargement faces a still readable and characteristic nineteenth-century building. Even introducing unavoidable innovative characteristics, the architecture we designed tries to resolve the difficult relationship between the new portion and the old cemetery, bell shaped, in steep slope above the town. The recovery of this place for collective memory, once realized as a closed enclosure, is realized by the mediation of a space which seeks to maintain, recover and reinforce the identity of places altered in the last years by uncon…
Profesores y estudiantes en la guerra civil española (1936-1939)
2011
Situación de profesores y estudiantes en la guerra civil española.
Revista de educación
2016
Los datos estadísticos suponen un elemento de gran relevancia para analizar la realidad educativa, independientemente de que esta sea, presente, pasada, global o parcial. Pese a su indudable trascendencia, los estudios de la denominada historia de la estadística escolar en España son muy escasos, especialmente los enmarcados en el siglo XX. El objetivo de este artículo es analizar los datos estadísticos referidos al bachillerato español en el periodo comprendido entre 1930 y 1970, haciendo especial hincapié en la presentación de la información, sus cambios y las razones que los motivaron. Para ello hemos efectuado, en primer término, una profunda revisión de las fuentes estadísticas disponi…
Revista complutense de educación
2019
espanolLa ensenanza secundaria espanola sufrio un notable cambio en la decada de 1950. Se produjo la ruptura efectiva del modelo de ensenanza dual, al permitir a chicos y chicas de familias obreras y de escasos ingresos accedieran al bachillerato, lo que les estaba practicamente vetado hasta entonces. Las autoridades educativas otorgaron tanta importancia a esa politica que tuvo denominacion especifica: la extension de la ensenanza media. Este trabajo se centra en el analisis del discurso que apoyo y explicito tal politica. Para ello se han localizado declaraciones y tomas de posicion de los principales responsables del ministerio de educacion que conformaron el discurso oficial que impulso…
La escultura pública en Valencia. Estudio y catálogo
2003
Estudio de la escultura monumental en la ciudad de Valencia, aproximándose al contexto histórico que la hizo posible, a los criterios estéticos de la época y al espacio urbano para el que fue concebida. El marco cronológico abarca desde el período gótico, con los primeros testimonios escultóricos documentados, símbolos sagrados del cristianismo, hasta la época contemporánea, con los hitos escultóricos de la urbe moderna, tan ajenos a los planteamientos estéticos y los procedimientos materiales de la tradicion estatuaria. El estudio está dividido en cinco capítulos, y describe un proceso ininterrumpido cuya trayectoria se identifica con las divisiones consensuadas en la Historia del Arte en …