Search results for "93"
showing 10 items of 1707 documents
“El Registro Civil y el contenido de su publicidad: experiencias españolas para el contexto cubano”
2021
La función de publicidad que caracteriza al Registro Civil lo convierte en una institución fundamental dentro del sistema de seguridad jurídica preventiva. De ahí que, sea importante estudiar si existe correspondencia entre el contenido de la publicidad del Registro y las situaciones jurídicas y sociales en que usualmente se desenvuelven las personas, como un medio para garantizar, desde esta perspectiva, su cuidado y desarrollo. En este sentido, se valora el contenido de la publicidad del Registro del Estado Civil cubano (Ley No.51/1985, de 15 de julio del Registro del Estado Civil), a partir de las experiencias españolas en la materia, siguiendo, en general, los avances de este último sis…
Deciphering genomic heterogeneity and the internal composition of tumour activities through a hierarchical factorisation model
2021
Genomic heterogeneity constitutes one of the most distinctive features of cancer diseases, limiting the efficacy and availability of medical treatments. Tumorigenesis emerges as a strongly stochastic process, producing a variable landscape of genomic configurations. In this context, matrix factorisation techniques represent a suitable approach for modelling such complex patterns of variability. In this work, we present a hierarchical factorisation model conceived from a systems biology point of view. The model integrates the topology of molecular pathways, allowing to simultaneously factorise genes and pathways activity matrices. The protocol was evaluated by using simulations, showing a hi…
Measurements of underlying-event properties using neutral and charged particles in pp collisions at root s=900 GeV and root s=7 TeV with the ATLAS de…
2011
We present first measurements of charged and neutral particle-flow correlations in pp collisions using the ATLAS calorimeters. Data were collected in 2009 and 2010 at centre-of-mass energies of 900 GeV and 7 TeV. Events were selected using a minimum-bias trigger which required a charged particle in scintillation counters on either side of the interaction point. Particle flows, sensitive to the underlying event, are measured using clusters of energy in the ATLAS calorimeters, taking advantage of their fine granularity. No Monte Carlo generator used in this analysis can accurately describe the measurements. The results are independent of those based on charged particles measured by the ATLAS …
Fixed Points for Multivalued Convex Contractions on Nadler Sense Types in a Geodesic Metric Space
2019
In 1969, based on the concept of the Hausdorff metric, Nadler Jr. introduced the notion of multivalued contractions. He demonstrated that, in a complete metric space, a multivalued contraction possesses a fixed point. Later on, Nadler&rsquo
Entry-Item-Quantity-ABC Analysis-Based Multitype Cigarette Fast Sorting System
2012
Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2012/847591 Open access Numerous items, small order, and frequent delivery are the characteristics of many distribution centers. Such characteristics generally increase the operating costs of the distribution center. To remedy this problem, this study employs the Entry-Item-Quantity (EIQ) method to identify the characteristic of the cigarette distribution center and further analyzes the importance degree of customers and the frequently ordered products by means of EQ/EN/IQ-B/IK statistic charts. Based on these analyses as well as the total rep…
Positive effects of an extracellular matrix hydrogel on rat anterior cruciate ligament fibroblast proliferation and collagen mRNA expression
2015
Summary Background/Objective We have previously shown that an extracellular matrix (ECM) bioscaffold derived from porcine small intestine submucosa (SIS) enhanced the healing of a gap injury of the medial collateral ligament as well as the central third defect of the patellar tendon. With the addition of a hydrogel form of SIS, we found that a transected goat anterior cruciate ligament (ACL) could also be healed. The result begs the research question of whether SIS hydrogel has positive effects on ACL fibroblasts (ACLFs) and thus facilitates ACL healing. Methods In the study, ECM-SIS hydrogel was fabricated from the digestion of decellularised and sterilised sheets of SIS derived from αGal-…
Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases
2005
Cleavage of the amyloid precursor protein (APP) within the amyloid-beta (Aβ) sequence by the α-secretase prevents the formation of toxic Aβ peptides. It has been shown that the disintegrin-metalloproteinases ADAM10 and TACE (ADAM17) act as α-secretases and stimulate the generation of a soluble neuroprotective fragment of APP, APPsα. Here we demonstrate that the related APP-like protein 2 (APLP2), which has been shown to be essential for development and survival of mice, is also a substrate for both proteinases. Overexpression of either ADAM10 or TACE in HEK293 cells increased the release of neurotrophic soluble APLP2 severalfold. The strongest inhibition of APLP2 shedding in neuroblastoma c…
Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease
1999
Amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains of Alzheimer’s disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP). Proteolytic cleavage of APP by a putative α-secretase within the Aβ sequence precludes the formation of the amyloidogenic peptides and leads to the release of soluble APPsα into the medium. By overexpression ofa disintegrinandmetalloprotease (ADAM), classified as ADAM 10, in HEK 293 cells, basal and protein kinase C-stimulated α-secretase activity was increased severalfold. The proteolytically activated form of ADAM 10 was localized by cell surface biotinylation in the plasma membrane, but the m…
Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens.
2015
Multidrug resistance (MDR) caused by human ABCB1 (P-glycoprotein/MDR1) is one of the major obstacles in chemotherapy. To understand the mechanism of MDR by ABCB1 and circumvent the MDR, in the present study, we established human ABCB1-expressing cells (Flp-In-293/ABCB1 cells) and examined the cytotoxic effects of four guanidine alkaloids from Pterogyne nitens (galegine, nitensidine A, pterogynidine and pterogynine) using Flp-In-293/Mock and Flp-In-293/ABCB1 cells. The activity of ABCB1 in Flp-In-293/ABCB1 cells were confirmed by typical substrates for ABCB1 (taxol and vinblastine) in MTT assay. Flp-In-293/ABCB1 cells were also resistant to the four guanidine alkaloids as well as taxol and v…
The lignan, (-)-sesamin reveals cytotoxicity toward cancer cells: pharmacogenomic determination of genes associated with sensitivity or resistance.
2013
(-)-Sesamin is a lignan present in sesam oil and a number of medicinal plants. It exerts various pharmacological effects, such as prevention of hyperlipidemia, hypertension, and carcinogenesis. Moreover, (-)-sesamin has chemopreventive and anticancer activity in vitro and in vivo. Multidrug resistance (MDR) of tumors leads to fatal treatment outcome in many patients and novel drugs able to kill multidrug-resistant cells are urgently needed. P-glycoprotein (MDR1/ABCB1) is the best known ATP-binding cassette (ABC) drug transporter mediating MDR. ABCB5 is a close relative to ABCB1, which also mediates MDR. We found that the mRNA expressions of ABCB1 and ABCB5 were not related to the 50% inhibi…