Search results for "97"

Experimental Research on the Cutting of Metal Materials by Electrical Discharge Machining with Contact Breaking with Metal Band as Transfer Object

2020

The scientific paper presents practical research carried out by a mixed team of Romanian researchers from universities and the business environment. The research consists in applying the process of cutting metallic materials through electrical discharge machining with contact breaking using a metal band as a transfer object. The research was implemented with the help of a specially designed installation in the laboratory and subsequently all the necessary steps were taken to obtain the patent for it. Various metallic materials were cut using this process, but first of all, high alloy steels. In the global research conducted by the authors, active experimental programs and classic experiment…

DESDEO: The Modular and Open Source Framework for Interactive Multiobjective Optimization

2021

Interactive multiobjective optimization methods incorporate preferences from a human decision maker in the optimization process iteratively. This allows the decision maker to focus on a subset of solutions, learn about the underlying trade-offs among the conflicting objective functions in the problem and adjust preferences during the solution process. Incorporating preference information allows computing only solutions that are interesting to the decision maker, decreasing computation time significantly. Thus, interactive methods have many strengths making them viable for various applications. However, there is a lack of existing software frameworks to apply and experiment with interactive …

De la botánica "inútil" a la ciencia aplicada. Simón de Rojas Clemente y Rubio

2015

Creiximent de la població, mortalitat, natalitat i migracions a les comarques de Tarragona (1700-1860)

2018

El ?Alivio de las Indias?. la Real Hacienda Filipina, 1565-1800

2019

Previo al estudio de la Real Hacienda filipina, el trabajo se centrará en la definición del marco territorial, la función del archipiélago en la estrategia imperial y la gran transformación de finales del siglo xVIII que afectó a su situación en el conjunto colonial. En segundo lugar, se expondrá el estado de la cuestión y las principales hipótesis sobre la evolución del Tesoro filipino y los problemas que planteaba su viabilidad, así como las fuentes y la metodología empleadas. A continuación se examinarán las grandes tendencias de la Hacienda en el largo plazo y los componentes del ingreso y el gasto, para finalizar con algunas conclusiones, en especial la respuesta a la siguiente pregunt…

El obispo Vicente Roca de la Serna y su sepulcro en san Juan de la Ribera, obra del maestro marmolista Juan Bautista Semería

2016

Incorporaciones de obras de arte a las colecciones de la Real Academia de Bellas Artes de San Carlos, 2015-2016

2016

Crude oil exposures reveal roles for intracellular calcium cycling in haddock craniofacial and cardiac development.

2016

AbstractRecent studies have shown that crude oil exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling. We previously found that eggs of Atlantic haddock (Melanogrammus aeglefinus) bind dispersed oil droplets, potentially leading to more profound toxic effects from uptake of polycyclic aromatic hydrocarbons (PAHs). Using lower concentrations of dispersed crude oil (0.7–7 μg/L ∑PAH), here we exposed a broader range of developmental stages over both short and prolonged durations. We quantified effects on cardiac function and morphogenesis, characterized novel craniofacial defects, and examined the expression of genes encoding potential targets underly…

Human Dental Pulp Stem Cells Exhibit Different Biological Behaviours in Response to Commercial Bleaching Products

2018

The purpose of this study was to evaluate the diffusion capacity and the biological effects of different bleaching products on human dental pulp stem cells (hDPSCs). The bleaching gel was applied for 90, 30 or 15 min to enamel/dentine discs that adapted in an artificial chamber. The diffusion of hydrogen peroxide (HP) was analysed by fluorometry and the diffusion products were applied to hDPSCs. Cell viability, cell migration and cell morphology assays were performed using the eluates of diffusion products. Finally, cell apoptosis and the expression of mesenchymal stem cell markers were analysed by flow cytometry. Statistical analysis was performed using analysis of variance and Kruskal&nda…

Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex.

2017

Persistent stress triggers a variety of mechanisms, which may ultimately lead to the occurrence of anxiety- and depression-related disorders. Epigenetic modifications represent a mechanism by which chronic stress mediates long-term effects. Here, we analyzed brain tissue from mice exposed to chronic unpredictable stress (CUS), which induced impaired emotional and nociceptive behaviors. As endocannabinoid (eCB) and neuropeptide-Y (Npy) systems modulate emotional processes, we hypothesized that CUS may affect these systems through epigenetic mechanisms. We found reduced Npy expression and Npy type 1 receptor (Npy1r) signaling, and decreased expression of the cannabinoid type 1 receptor (CB1) …