Search results for "9"

Evaluation of web reinforcements in prestressed concrete box girders through shear-transverse bending domains

2020

In concrete box girders, the amount and distribution of reinforcements in the webs have to be estimated considering the local effects due to eccentric external loads and cross-sectional distortion and not only the global effect due to the resultant forces of a longitudinal analysis: shear, torsion and bending. This work presents an analytical model that allows designers to take into account the interaction of all these effects, global and local, for the determination of the reinforcements. The model is based on the theory of stress fields and it has been compared to a 3D finite element analysis, in order to validate the interaction domains. The results show how the proposed analytical mode…

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

MODIFICATION OF HYDROPHOBIC SURFACE WITH POLYASPARTAMIDE-BASED POLYCATIONS FOR BIOMEDICAL APPLICATION

2013

A convenient way for the achievement of polymer-based solid materials for specific biomedical applications is grafting the appropriate macromolecules onto the surfaces in order to confer them specific properties. To date many approaches have been used to covalently modify polymeric surfaces, and among them chemoselective coupling reactions, usually referred as “click” reactions, gained much attention thanks to simple procedure with high reaction rate under mild reaction conditions (at normal temperature and pressure) [1]. In particular, radical-initiated thiol-yne “photo-click” chemistry has been demonstrated as an effective way to functionalize efficiently surfaces. This method gives also …

The new face of university–business cooperation in Finland

2016

This paper analyses the development of university-business cooperation (UBC) in Finland in the context of the University Reform Act of 2009, drawing on the experience of four universities: Aalto University, University of Jyvaskyla, University of Turku, and Lappeenranta University of Technology. Six UBC dimensions are examined: institutional context, stakeholders, motivations, facilitators/inhibitors, benefits, and drawbacks. We find that UBC, while a relatively recent process, is growing fast in dynamic local innovation and entrepreneurship ecosystems. The University Act of 2009 had an uneven effect on the six UBC dimensions, with the most visible impact being manifested on motivations. Aal…

Violência, evasão e exclusão na educação superior

2019

The present text focuses on a relationship between higher education, institutional and symbolic violence and exclusion, practicing as a challenge based on reflections on the existence of evasion in Brazilian university. Ignoring the educational institution as a direct responsible for these things, this text considers that a logic in University organization and operation helps to enlarge inequalities that provide the mechanisms of evasion; at the same time, it presents itself as a space of reference and a struggle against social inequalities and violence. On a provisional basis, the text stands out that: depending on the execution of educational procedures and practices undertaken by the ins…

Verifying the predicted risk of extinction based on ecological characteristics

2021

Red List status of species should reflect species extinction risk. Because data are limited and species response has a time lag, species may be threatened by extinction even if they are not Red‐Listed. The ability to predict species risk of extinction from ecological characteristics holds promises for proactively targeting conservation measures to species at high risk. In 2005, the risk of extinction from ecological characteristics was predicted for 81 species of Finnish butterflies. Now, after 15 years and two additional national Red List assessments, these predictions are verified. Species with a higher risk of extinction according to the original ecological extinction risk rank (EERR) ha…

Testing and Modeling of Hybrid Steel-Trussed Concrete Beams in Shear

2014

ACTO II / ACT II Mujeres / Women ¿Es gay la música de Chopin? Aspectos de la recepción de la música de Chopin en el siglo XIX

2021

Considering that it is difficult, if not impossible, for an analysis of Chopin?s music to unmask some aspects of his private life (such as an alleged sexual and affective attraction for individuals of his own sex), we can however argue that, throughout the 19th century, a connection was established between his work and a ?feminine universe.? That connection might have had implications in the way in which the feminized image of its author was constructed. The analysis of certain aesthetic and stylistic traits of Chopin?s music can help understand the causes of that perception.

THYROID DISORDERS

2012

Long-Term Data Reveal the Associations of the Egg Quality With Abiotic Factors and Female Traits in the Baltic Herring Under Variable Environmental C…

2021

In fish, the lipid resources of the female form a link between the environment and progeny, contributing to the contents of the egg yolk. Variation of the environmental conditions is therefore expected to affect the egg quality via maternal pathways, reflecting the female’s response to the environmental factors before spawning. We investigated the content of lipids and thyroid hormones in the ovary and eggs of the Baltic herring during 1988–2019, when salinity of the Baltic Sea first declined and then stabilized to a lower level, and winters varied between severe and mild. The total lipid resources of spawning females decreased by 40–50% during the study, and the ovarian lipid concentration…