Search results for "A13"
showing 8 items of 18 documents
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13
2021
CYP2A13 enzyme is expressed in human extrahepatic tissues, while CYP2A6 is a hepatic enzyme. Reactions catalysed by CYP2A13 activate tobacco-specific nitrosamines and some other toxic xenobiotics in lungs.To compare oxidation characteristics and substrate-enzyme active site interactions in CYP2A13 vs CYP2A6, we evaluated CYP2A13 mediated oxidation characteristics of 23 coumarin derivatives and modelled their interactions at the enzyme active site.CYP2A13 did not oxidise six coumarin derivatives to corresponding fluorescent 7-hydroxycoumarins. The Km-values of the other coumarins varied 0.85���97 ��M, Vmax-values of the oxidation reaction varied 0.25���60 min���1, and intrinsic clearance var…
La economía social como enfoque metodológico, como objeto de estudio y como disciplina científica
1999
This article continues an article written by the same author and published by CIRIEC-España in 1997 (no. 25). It analyses social economy at three cognitive levels: first, as a social reality (Social Economy); second, as a scientific discipline which studies its previous reality (the science of Social Economy); third, as a methodological approach in social sciences (the approach of Social Economy). The author claims that, at these three levels, social economy becomes an alternative way of “making the economy”.
Teoría de la Participación. Sugerencias analíticas
2002
Human groups may be analysed as organisations of networks of relationships between their members. This article proposes an exercise in theoretic speculation about participation and democracy based on the analytic tools of a relational-informational theory the bases of which come from evolutionalism and the Information Economy. This analytical framework may clarify the nature of macro-collective citizenship, micro-formal group of the company and the fabric of the emergent and informal communicative relations of society and the market. As a humanist heuristic which revindicates the resource to literary and philosophic sources of knowledge, work offers alternative explainations to the preferen…
BETWEEN SUBJECTIVE AND OBJECTIVE IN MAKING DECISIONS ON THE ROMANIAN HIGHER EDUCATION MARKET
2012
Having roots in intentional behaviours, adverse selection as part of information asymmetry is a widely - discussed concept, closely related to many sides of economics and generating the most various problems in practice. As the specific literature says, the adverse selection leads, or at least in theory should lead to market failure when no external force comes to balance its effects. Since this failure never occurs in fact, it is questionable whether the adverse selection is the only factor that influences an uniformed consumer decision, or other factors come to counterbalance the factors described by Akerloff. This paper intends to advocate the idea that as much as adverse selection, ther…
Developing a Conceptual Framework for Investigating Communication Supporting Community Resilience
2015
In crisis management, cooperation within the response network is seen as crucial. Usually, this network refers to authorities and nongovernmental organizations, such as the Red Cross. However, the authors argue that to improve societal resilience one should take a broader overview of the actors involved in crisis preparedness and mitigation, and also include the public. With this in mind, the role of communication is scrutinized and a conceptual framework developed as a starting point for further investigation into how communication may be developed to strengthen a community approach to crisis management that includes citizen groups in the broader response network. A model is presented alon…
Towards Sustaining Levels of Reflective Learning: How Do Transformational Leadership, Task Interdependence, and Self-Efficacy Shape Teacher Learning …
2015
Whereas cross-sectional research has shown that transformational leadership, task interdependence, and self-efficacy are positively related to teachers’ engagement in reflective learning activities, the causal direction of these relations needs further inquiry. At the same time, individual teacher learning might play a mutual role in strengthening school-level capacity for sustained improvement. Building on previous research, this longitudinal study therefore examines how transformational leadership, task interdependence, self-efficacy, and teachers’ engagement in self-reflection mutually affect each other over time. Questionnaire data gathered on three measurement occasions from 655 Dutch …
Public Discourse on Human Trafficking in International Issue Arenas
2015
Abstract. The purpose of this study is to better understand how the complex problem of human trafficking is addressed in international debates. How the discussion about human trafficking develops and how it is debated ultimately influences how the decision-making process unfolds. In order to understand the formation of public policy and laws, therefore, it is important to study the debate that occurs prior to decision making. This analysis focuses on the narratives used by major, well-established human rights and political actors that argue for necessary actions to be undertaken — such as the formation of new policies and laws in the European Union — as an attempt to protect citizens of the…
Don't tell us: the demand for secretive bahaviour
2009
International audience