Search results for "A2"
showing 10 items of 1101 documents
Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain
2009
Calcium sensing receptor (CaSR), isolated for the first time from bovine and human parathyroid, is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expr…
Hemodynamic responses to speech and music in newborn infants
2009
We used near‐infrared spectroscopy (NIRS) to study responses to speech and music on the auditory cortices of 13 healthy full‐term newborn infants during natural sleep. The purpose of the study was to investigate the lateralization of speech and music responses at this stage of development. NIRS data was recorded from eight positions on both hemispheres simultaneously with electroencephalography, electrooculography, electrocardiography, pulse oximetry, and inclinometry. In 11 subjects, statistically significant (P < 0.02) oxygenated (HbO(2)) and total hemoglobin (HbT) responses were recorded. Both stimulus types elicited significant HbO(2) and HbT responses on both hemispheres in five subjec…
Comparative changes between pancreas and pancreatic juice digestive enzyme contents during nutritional rehabilitation following severe protein malnut…
1993
The relationship between digestive enzyme activities in the pancreas and pancreatic juice was studied in post-weaning rats fed on a low-protein diet (30 g cereal protein/kg) for 1 month and a refeeding balanced diet (235 g mixed protein/kg) for the following 3 months. A control group was fed on the balanced diet for 4 months. At the end of malnutrition and at various times of refeeding, activities of amylase (EC3.2.1.1), trypsin(EC3.4.21.4), chymotrypsin (EC3.4.21.1), lipase (EC3.1.1.3), phospholipase A2 (EC3.1.1.4) and cholesterolesterase (EC3.1.1.13) in pancreas and pancreatic juice were measured. Recovery of body and pancreas weights was obtained after 3 months of refeeding. Pancreas off…
Release of choline from rat brain under hypoxia: contribution from phospholipase A2 but not from phospholipase D
1993
Moderate hypoxia induced in rats by inhalation of 10% oxygen led to an increase of the concentration of free choline in the brain and caused a large net-release of choline from the brain into the venous blood as determined by the measurement of the arterio-venous difference. In hippocampal slices from rat brain, hypoxia increased the release of choline into the superfusion medium. The activity of phospholipase D, as measured by the formation of phosphatidylpropanol in the presence of propanol, was not stimulated under these conditions. However, the mobilization of choline was completely depressed by lowering extracellular calcium and by 0.1 mM mepacrine. We conclude that hypoxia leads to a …
Inadequate oral anticoagulation with warfarin in women with cerebrovascular event and history of atrial fibrillation: the FibStroke study
2021
Abstract Background Women with atrial fibrillation (AF) may be treated less actively with oral anticoagulation (OAC) than men. Patients and methods We assessed sex differences in the implementation of stroke risk stratification with CHADS2 and CHA2DS2-VASc scores and reasons not to use OAC in 1747 AF patients suffering their first cerebrovascular event after the AF diagnosis. Results Women were older and had more often a high stroke risk (CHADS2/CHA2DS2-VASc ≥2) than men (p < .001). On admission, 46.4% of women and 48.2% of men were on OAC with no sex difference (p = .437). However, of patients without OAC, 74.4% of women and 49.5% of men should have been on OAC based on CHADS2/CHA2DS2-VASc…
Involvement of plasmalogens in post-natal retinal vascular development
2014
Objective: Proper development of retinal blood vessels is essential to ensure sufficient oxygen and nutrient supplies to the retina. It was shown that polyunsaturated fatty acids (PUFAs) could modulate factors involved in tissue vascularization. A congenital deficiency in ether-phospholipids, also termed "plasmalogens'', was shown to lead to abnormal ocular vascularization. Because plasmalogens are considered to be reservoirs of PUFAs, we wished to improve our understanding of the mechanisms by which plasmalogens regulate retinal vascular development and whether the release of PUFAs by calcium-independent phospholipase A2 (iPLA2) could be involved. [br/] Methods and Results: By characterizi…
Processing and MHC class I presentation of human cytomegalovirus pp65-derived peptides persist despite gpUS2–11-mediated immune evasion
2007
Immune control of human cytomegalovirus (HCMV) infection can be mediated by CD8+cytolytic T lymphocytes (CTL). Adoptive transfer of antiviral CTL confers protection against HCMV reactivation and disease. The tegument protein pp65 and the immediate-early 1 protein (IE1) are recognized to be major CTL targets, even though during productive infection the viral immunoevasion proteins gpUS2–11 act to suppress major histocompatibility complex (MHC) class I-restricted antigen presentation. Thus it was not clear how infected cells could be labelled with antigenic peptides in the face of immunoevasion. We show here that the immunodominant peptide pp65NLVwas presented by MHC class I in cells infected…
Mass transport problems obtained as limits of p-Laplacian type problems with spatial dependence
2014
Abstract. We consider the following problem: given a bounded convex domain Ω ⊂ ℝ N ${\Omega \subset \mathbb {R}^N}$ we consider the limit as p → ∞ of solutions to - div ( b p - p | D u | p - 2 D u ) = f + - f - ${- \operatorname{div} (b_{p}^{-p} |Du|^{p-2} Du)=f_+ - f_-}$ in Ω and b p - p | D u | p - 2 ∂ u ∂ η = 0 ${ b_{p}^{-p} |Du|^{p-2} \frac{\partial u}{\partial \eta }=0}$ on ∂ Ω ${\partial \Omega }$ . Under appropriate assumptions on the coefficients bp that in particular verify that lim p → ∞ b p = b ${ \lim _{p\rightarrow \infty } b_p = b }$ uniformly in Ω ¯ ${\overline{\Omega }}$ , we prove that there is a uniform limit of u p j ${u_{p_j}}$ (along a sequence p j → ∞ ${p_j \rightarrow…
Social Network-Based Content Delivery in Device-to-Device Underlay Cellular Networks Using Matching Theory
2017
With the popularity of social network-based services, the unprecedented growth of mobile date traffic has brought a heavy burden on the traditional cellular networks. Device-to-device (D2D) communication, as a promising solution to overcome wireless spectrum crisis, can enable fast content delivery based on user activities in social networks. In this paper, we address the content delivery problem related to optimization of peer discovery and resource allocation by combining both the social and physical layer information in D2D underlay networks. The social relationship, which is modeled as the probability of selecting similar contents and estimated by using the Bayesian nonparametric models…
Assembly of citrate gold nanoparticles on hydrophilic monolayers
2016
Abstract Self-assembled monolayers (SAMs) as model surfaces were linked onto planar gold films thorough lipoic acid or disulfide groups. The molecules used were polyethylene glycol (EG-S-S), N -[tris-(hydroxymethyl)methyl]acrylamide polymers with and without lipoic acid (Lipa-pTHMMAA and pTHMMAA) and a lipoic acid triazine derivative (Lipa-MF). All the layers, but Lipa-MF with a primary amino group were hydroxyl terminated. The layers were characterized by contact angle measurements and atomic force microscopy, AFM. Citrate stabilized nanoparticles, AuNPs in water and phosphate buffer were allowed to assemble on the layers for 10 min and the binding was followed in real-time with surface pl…