Search results for "AA"
showing 10 items of 16992 documents
Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification o…
2001
Abstract Appropriate regulation of IL-12 expression is critical for cell-mediated immune responses. In the present study, we have analyzed the regulation of IL-12 p40 promoter activity in primary human monocytes in vivo. Accordingly, we analyzed the p40 promoter by in vivo footprinting in resting and activated primary human blood CD14+ monocytes. Interestingly, footprints at binding sites for trans-activating proteins such as C/EBP, NF-κB, and ETS were only found upon stimulation with LPS and IFN-γ. In contrast, a footprint over a purine-rich sequence at −155, termed GA-12 (GATA sequence in the IL-12 promoter), was observed in resting, but not activated, cells. Further characterization of t…
The impact of DAA-mediated HCV eradication on CD4+ and CD8+ T lymphocyte trajectories in HIV/HCV coinfected patients: Data from the ICONA Foundation …
2021
HCV infection has been hypothesized as a contributor of poor CD4+ recovery in patients living with HIV (PLWHIV). Aim of this study was to evaluate CD4+, CD8+ cells and CD4/CD8 ratio trends before and after HCV treatment with direct acting agents (DAA) in PLWHIV. HIV/HCV patients enrolled in ICONA and HepaICONA cohorts with HIV-RNA≤50 copies/ml who achieved a sustained viral response after DAA treatment were studied. A linear regression model was used to investigate CD4+, CD8+ and CD4/CD8 changes 12 months before and after DAA treatment. A total of 939 HIV/HCV patients were included, 225 (24.0%) female, median age: 53 years (IQR 50–56). At DAA initiation, CD4+ T cell count was <350 cells/…
Crisis management in social media : maintaining the organizational image
2017
The field of crisis communication has faced major changes since the expansion of internet and social media platforms. The difficulty of using social media platforms to or-ganizations’ own advantage in crisis situations has become a recent topic of discussion amongst professionals. The image of an organization provides them competitive advantage in multiple fields, so it is vital to manage these situations so the image remains positive with stakeholders. This thesis aims to provide insights for organizations on how to utilize social media in their crisis communication. 11 Finnish companies with crisis situations during the year 2016 were identified and the data was retrieved from social medi…
Examining the Competencies of the Chief Digital Officer
2018
Adolescents' school-related self-concept mediates motor skills and psychosocial well-being.
2014
Background The health benefits of exercise participation and physical activity for mental health and psychosocial well-being (PSWB) have been shown in several studies. However, one important background factor, that is, motor skills (MSs), has largely been ignored. In addition, most of the existing research focuses on poor MSs, that is, poor MSs are often connected to poorer PSWB. The mechanism linking MSs and PSWB is unclear. However, a preliminary suggestion has been made that self-worth or self-perceptions might mediate the association between MSs and PSWB. Aim We investigated whether the self-concepts (SCs) of school-related physical education (SCPE), reading (SCR), and mathematics (SCM)…
Rate-retarding effects of mixed anionic/non-ionic micelles on the alkaline hydrolysis of the chloropentamminocobalt(III) complex - Role of the anioni…
2006
Rate data for the alkaline hydrolysis of the chloropentaamminecobalt(III) cation in the presence of mixed micelles composed of (i) anionic sodium decylsulphate (SDeS) and non-ionic dodecylpenta(oxyethylene glycol) monoether (C12E5) surfactants and (ii) anionic sodium perfluorooctanoate (SPFO) and non-ionic C12E5 surfactants has been obtained at T 298K and constant electrolyte concentration 0.08 mol dm−3 ([NaOH] = 0.01 mol dm−3, [NaClO4] = 0.07 mol dm−3) over a wide range of total surfactant concentration (Ct) and anionic mole fraction (χ). The critical micelle concentrations (c.m.c.s) of the mixed micelles have been determined over the entire χ range by means of surface tension measurements…
"Tässä ryhmässä olen aika hyvä" : ekologinen näkökulma kielenoppijaidentiteetteihin peruskoulun viidennen ja kuudennen luokan englannin opetuksessa
2012
Similarities between Playing World of Warcraft and CLIL
2012
This article argues that playing World of Warcraft (WoW) and Content and Language Integrated Learning (CLIL) have a number of similar features. We base our argument on findings from three studies. The first (Sylvén 2004/2010) is about CLIL and non-CLIL students at upper secondary level and aims to investigate what effect, if any, CLIL has on the incidental acquisition of vocabulary. The second (Sundqvist 2009) is about extramural English and aims to examine its potential impact on learners’ oral proficiency and vocabulary. Extramural English is broadly defined as any type of contact that learners have with English outside the classroom. The third is a joint study focusing on young learners …
Female style vs. male style or something in between? : a case study on gendered communication on the Humans of New York Facebook page
2015
Sosiaalinen media on viime vuosikymmenen aikana mullistanut internetin avulla tapahtuvaa viestintää ja sen tuomia uusia mullistuksia onkin tutkittu tieteellisesti paljon viime aikoina. Sukupuolen ja kielen roolia sosiaalisen median myllerryksessä ei viestinnällisestä näkökulmasta kuitenkaan ole tutkittu kovin paljon ja siksi tämän tutkimuksen tarkoituksena oli kartoittaa, millaista naisten ja miesten kielenkäyttö on nykyään internetissä ja miten se peilautuu aiempien tutkimustulosten valossa. Tutkimuksen aineisto koostui 170 tavallisten ihmisten kirjoittamista kommenteista, jotka valittiin suositulta Humans of New York Facebook-sivulta tammikuun 2015 aikana. Nämä kommentit jaettiin laadulli…