Search results for "AAS"

Kalmbergin kartasto R VIa : List 5

1856

Kalmbergin kartasto R I : List 10

1855

Kalmbergin kartasto R II : List 11

1855

Kalmbergin kartasto R I : List 11

1855

Current and future challenges in HCV: insights from an Italian experts panel

2017

Background: The recent availability of direct acting antiviral drugs (DAAs) has drastically changed hepatitis C virus (HCV) treatment scenarios, due to the exceedingly high rates of sustained virological response (SVR) and excellent tolerability allowing for treatment at all disease stages. Methods: A panel of Italian experts was convened twice, in November 2016 and January 2017, to provide further support on some open issues and provide guidance for personalized HCV care, also in light of forthcoming regimens. Results and conclusions: Treatment recommendations issued by international and national liver societies to guide clinicians in the management of HCV infection are constantly updated …

Microreflectivity studies of wavelength control in oxidised AlGaAs microcavity

2002

Two differet ways of being modern

2005

Il confronto tra l''ambasciata di Olanda di OMA e lo stadio di Braga di Souto de Moura dimostra come nella loro diversità gli edifici siano entrambi moderni. Il primo apparentemente “diverso” lavora dentro le regole della città senza conferire all''architettura valore dimostrativo. Il secondo, sebbene lavori in una dimensione più arcaica dell''architettura, completa la città con il suo programma liberandosi dall''automatismo che lega la funzione dell''edificio al tipo e all''immagine dello stesso.

The emission reduction potential of electric transport modes in Finland

2021

The transportation sector has become the fastest growing source of greenhouse gas (GHG) emissions. One solution to mitigate the impacts is a shift towards electric modes. Where previous studies have only focused on the replacement of individual modes, our study presents a more holistic approach by comparing land-based, water-based and airborne transportation modes. We study the GHG emission reduction potentials of electric cars, buses, trains, ferries and aircraft in comparison to existing modes on 34 routes within Finland and across the Baltic Sea to Sweden and Estonia. By comparing the GHG emissions in carbon dioxide equivalents (CO2-eq) per passenger kilometer for each mode, we also cons…

Structural mechanism of signal transduction in a phytochrome histidine kinase

2022

AbstractPhytochrome proteins detect red/far-red light to guide the growth, motion, development and reproduction in plants, fungi, and bacteria. Bacterial phytochromes commonly function as an entrance signal in two-component sensory systems. Despite the availability of three-dimensional structures of phytochromes and other two-component proteins, the conformational changes, which lead to activation of the protein, are not understood. We reveal cryo electron microscopy structures of the complete phytochrome from Deinoccocus radiodurans in its resting and photoactivated states at 3.6 Å and 3.5 Å resolution, respectively. Upon photoactivation, the photosensory core module hardly changes its ter…

Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase

2017

Sensor histidine kinases are central to sensing in bacteria and in plants. They usually contain sensor, linker, and kinase modules and the structure of many of these components is known. However, it is unclear how the kinase module is structurally regulated. Here, we use nano- to millisecond time-resolved X-ray scattering to visualize the solution structural changes that occur when the light-sensitive model histidine kinase YF1 is activated by blue light. We find that the coiled coil linker and the attached histidine kinase domains undergo a left handed rotation within microseconds. In a much slower second step, the kinase domains rearrange internally. This structural mechanism presents a t…