Search results for "AAT"
showing 10 items of 6105 documents
Physical activity intention and attendance behaviour in Finnish youth with cerebral palsy – results from a physical activity intervention: an applica…
2021
Physical activity is associated with better health in individuals with cerebral palsy (CP). Numerous physical activity interventions have been designed to promote physical activity among youth with CP. No previous studies have explored the factors contributing to the intention to participate and predicting attendance behaviour for these interventions. Using theory of planned behaviour (TPB), this study explored the prediction of physical activity intention and attendance behaviour in a physical activity intervention aiming to promote physical activity in a sample of young individuals with CP. Males with CP aged 9–21 years were asked to complete measures of attitude, subjective norms, percei…
CVG-ICP-OES -menetelmän käyttö elohopean analysointiin eläinkudoksesta
2015
Tässä Pro gradu –tutkielmassa käsitellään elohopean määritystä eläinkudoksesta kemiallinen höyryn muodostus induktiivisesti kytketty plasma optinen emissio spektrometria –menetelmällä (CVG-ICP-OES) ja siihen liittyvää näytteenkäsittelyä. Tutkimuksen kirjallisessa osassa käydään läpi muun muassa eri näytteenliuotusmenetelmiä, analyysimenetelmiä, tutkittavien metallien pelkistämistä CVG-ICP-OES –analyysiä varten ja CVG-ICP-OES –analyysissä esiintyviä häiriöitä. Näytteenliuotusosassa keskitytään pääasiassa tutkimuksessa käytetyn ultraäänihajotuksen esittelyyn, tämän lisäksi myös muita yleisiä näytteenliuotusmenetelmiä esitetään. Analyysimenetelmä osiossa suurin huomio keskittyy ICP-OES –laitte…
The effect of experimental lead pollution on DNA methylation in a wild bird population
2021
Anthropogenic pollution is known to negatively influence an organism’s physiology, behaviour, and fitness. Epigenetic regulation, such as DNA methylation, has been hypothesized as a potential mechanism to mediate such effects, yet studies in wild species are lacking. We first investigated the effects of early-life exposure to the heavy metal lead (Pb) on DNA methylation levels in a wild population of great tits (Parus major), by experimentally exposing nestlings to Pb at environmentally relevant levels. Secondly, we compared nestling DNA methylation from a population exposed to long-term heavy metal pollution (close to a copper smelter), where birds suffer from pollution-related decrease in…
Mental Health and Adherence to COVID-19 Protective Behaviors among Cancer Patients during the COVID-19 Pandemic: An International, Multinational Cros…
2021
Simple Summary Whilst information on the impact of COVID-19 on cancer care continues to increase exponentially, little is known about the impact of COVID-19 on the mental health and coping behaviors of cancer patients. This study constitutes a sub-study of a large international survey conducted during the first wave of the pandemic, looking specifically at the impact of COVID-19 on the mental health and protective behaviors of cancer participants, compared to non-cancer participants. It also explored whether cancer participants perceived COVID-19 as a bigger threat compared to their cancer and whether this perception affected their psychological outcomes, such as their perceived level of st…
Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems
2023
AbstractTheoretical and applied cancer studies that use individual-based models (IBMs) have been limited by the lack of a mathematical formulation that enables rigorous analysis of these models. However, spatial cumulant models (SCMs), which have arisen from theoretical ecology, describe population dynamics generated by a specific family of IBMs, namely spatio-temporal point processes (STPPs). SCMs are spatially resolved population models formulated by a system of differential equations that approximate the dynamics of two STPP-generated summary statistics: first-order spatial cumulants (densities), and second-order spatial cumulants (spatial covariances).We exemplify how SCMs can be used i…
KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer
2022
Background: KRAS mutations, present in over 40% of metastatic colorectal cancer (mCRC), are negative predictive factors for anti-EGFR therapy. Mutations in KRAS-G12C have a cysteine residue for which drugs have been developed. Published data on this specific mutation are conflicting; thus, we studied the frequency and clinical characteristics in a real-world and population-based setting. Methods: Patients from three Nordic population-based cohorts and the real-life RAXO-study were combined. RAS and BRAF tests were performed in routine healthcare, except for one cohort. The dataset consisted of 2,559 patients, of which 1,871 could be accurately classified as KRAS, NRAS, and BRAF-V600E. Demog…
Energy availability during training camp is associated with signs of overreaching and changes in performance in young female cross-country skiers
2021
Abstract Study aim: The aim of this study was to evaluate if young female skiers meet their energy and macronutrient requirements, and how energy availability (EA) and macronutrient intake affects their performance during an intensive training camp. Material and methods: 19 female cross-country skiers (age 16.7 ± 0.7) filled in 48-hour food and training logs during a 5-day training camp. Fasting concentrations of hemoglobin, leptin, triiodothyronine (T3), insulin, insulin-like growth factor 1 (IGF-1), and glucose were measured before (PRE) and after (POST) the camp. Blood lactate (LA), heart rate (HR) and rating of perceived exertion (RPE) from a submaximal treadmill running test, jump heig…
Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells.
1998
Cytochrome P450 (CYP) activity is very low or even absent in human hepatomas, a phenomenon that is accompanied by low levels of some liver transcription factors, notably C/EBP alpha. To investigate a possible link between this transcription factor and hepatic CYP expression, we have stably transfected HepG2 cells with a C/EBP alpha vector containing a Zn-inducible metallothionein promoter. Expression of functional C/EBP alpha up to liver levels concomitantly increased the mRNAs of several members of the CYP2 family (2B6, 2C9 and 2D6), suggesting that this transcription factor may play a relevant role in controlling the hepatic expression of CYP enzymes.
Physical activity and risk of atrial fibrillation in the general population : meta-analysis of 23 cohort studies involving about 2 million participan…
2021
Regular physical activity is well established to be associated with reduced risk of cardiovascular disease outcomes. Whether physical activity is associated with the future risk of atrial fibrillation (AF) remains a controversy. Using a systematic review and meta-analysis of published observational cohort studies in general populations with at least one-year of follow-up, we aimed to evaluate the association between regular physical activity and the risk of AF. Relevant studies were sought from inception until October 2020 in MEDLINE, Embase, Web of Science, and manual search of relevant articles. Extracted relative risks (RRs) with 95% confidence intervals (CIs) for the maximum versus the …
Effects of sauna bath on heart failure : A systematic review and meta-analysis
2018
Background: Sauna bath has potential as a lifestyle treatment modality for heart failure (HF). It is important to analyze the current evidence to help suggest paths of future study and potential for clinical application. Hypothesis: Sauna bath has a positive effect on HF patients. Methods: PubMed, Cochrane Library, and CINAHL databases were searched to identify randomized and nonrandomized controlled studies to compare effects of sauna bath with no sauna bath. Studies were searched for both infrared sauna bath and Finnish sauna bath. The strength of evidence was rated using a modified GRADE approach. Out of 1444 studies, nine met the inclusion criteria and were included in this review. Seve…