Search results for "ABA"
showing 10 items of 5735 documents
Stationary battery systems in the main world markets: Part 1: Overview of the state-of-the-art
2017
The role of energy storage systems (ESSs) is becoming more and more important in modern power grids, mainly because of the higher penetration of intermittent renewable energy sources (RESs), such as solar and wind power, spurred by advantageous support policies carried out in several countries. The fluctuation nature of the energy produced by RESs is indeed leading to emerging power quality issues or to renewable curtailments. ESSs can be used to balance generation and demand of electricity over time, allowing a higher penetration of RESs into the power network. The energy storage industry is evolving rapidly, and new electrochemical technologies are entering the market. Besides, most elect…
Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: Rationale and design of the HoT-PE Trial
2016
SummaryPulmonary embolism (PE) is a potentially life-threatening acute cardiovascular syndrome. However, more than 95 % of patients are haemodynamically stable at presentation, and among them are patients at truly low risk who may qualify for immediate or early discharge. The Home Treatment of Pulmonary Embolism (HoT-PE) study is a prospective international multicentre single-arm phase 4 management (cohort) trial aiming to determine whether home treatment of acute lowrisk PE with the oral factor Xa inhibitor rivaroxaban is feasible, effective, and safe. Patients with confirmed PE, who have no right ventricular dysfunction or free floating thrombi in the right atrium or ventricle, are eligib…
Technological and legislative status point of stationary energy storages in the EU
2019
Abstract European renewable generation has been supported through several policy instruments in the last decades, and this has caused a significant growth of the renewable energy sector, spurred by the ambitious climate and energy policy targets. Despite this impetuous growth, the electricity infrastructure is not yet ready to accept increasing shares of variable renewable energy sources (RES) generation, and this is causing grid balance challenges, due to the inherently variable nature of the PV and wind energy. In order to overcome this issue, allowing higher shares of renewable generation in the energy sector, energy storage (ES) systems are becoming increasingly competitive in the globa…
GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex
2010
Radial neuronal migration in the cerebral cortex depends on trophic factors and the activation of different voltage- and ligand-gated channels. To examine the func- tional role of GABAC receptors in radial migration we ana- lyzed the effects of specific GABAA and GABAC receptor antagonists on the migration of BrdU-labeled neurons in vitro using organotypic neocortical slice cultures. These experi- ments revealed that the GABAA specific inhibitor bicuculline methiodide facilitated neuronal migration, while the GABAC specific inhibitor (1,2,5,6-tetrahydropyridine-4-yl) methylphos- phinic-acid (TPMPA) impeded migration. Co-application of TPMPA and bicuculline methiodide or the unspecific ionot…
Exploiting historical rainfall and landslide data in a spatial database for the derivation of critical rainfall thresholds
2017
Critical rainfall thresholds for landslides are powerful tools for preventing landslide hazard. The thresholds are commonly estimated empirically starting from rainfall events that triggered landslides in the past. The creation of the appropriate rainfall–landslide database is one of the main efforts in this approach. In fact, an accurate agreement between the landslide and rainfall information, in terms of location and timing, is essential in order to correctly estimate the rainfall–landslide relationships. A further issue is taking into account the average moisture conditions prior the triggering event, which reasonably may be crucial in determining the sufficient amount of precipitation.…
Students' Perceptions on Engaging Database Domains and Structures
2023
Several educational studies have argued for the contextualization of assignments, i.e., for providing a context or a story instead of an abstract or symbolic problem statement. Such contextualization may have beneficial effects such as higher student engagement and lower dropout rates. In the domain of database education, textbooks and educators typically provide an example database for context. These are then used to introduce key concepts related to database design, and to illustrate querying. However, it remains unstudied what kinds of database contexts are engaging for novices. In this paper, we study which aspects of database domain and complexity students find engaging through student…
La inmigración y el origen del Trabajo Social. Una historia en común
2021
El objeto de este artículo es vincular la inmigración con el Trabajo Social en los Estados Unidos y Gran Bretaña. A partir de la revisión de fuentes secundarias, se trata de establecer la contribución de las figuras pioneras del Trabajo Social y mostrar las principales aportaciones de la disciplina a la investigación y la intervención en el campo de las migraciones. Entre estas aportaciones destaca una literatura, en general, poco conocida, así como una serie de experiencias institucionales que se han considerado como los orígenes históricos del Trabajo Social contemporáneo. The aim of this article is to link immigration with social work in the United States and Great Britain. The article r…
Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors
2009
Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…
Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis.
2018
Background Previous systematic reviews have reported positive associations between Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new primary studies, there is a need for a comprehensive systematic review. Our objectives were to investigate if MCs are associated with non-specific LBP and/or activity limitation and if such associations are modified by other factors. Methods A protocol for this review was registered at PROSPERO prior to commencing the work (PROSPERO record: CRD42015017350). The MEDLINE, CINAHL and EMBASE databases were searched for relevant studies from first record to June 15th 2016. Prospective or retrospective cross-sectional cohort studies …
Next-generation sequencing: big data meets high performance computing
2017
The progress of next-generation sequencing has a major impact on medical and genomic research. This high-throughput technology can now produce billions of short DNA or RNA fragments in excess of a few terabytes of data in a single run. This leads to massive datasets used by a wide range of applications including personalized cancer treatment and precision medicine. In addition to the hugely increased throughput, the cost of using high-throughput technologies has been dramatically decreasing. A low sequencing cost of around US$1000 per genome has now rendered large population-scale projects feasible. However, to make effective use of the produced data, the design of big data algorithms and t…