Search results for "ABO"

showing 10 items of 13628 documents

Characterization of the metabolic profile and identification of potential therapeutic targets in advanced prostate cancer patients

2023

INTRODUCCIÓN El cáncer de próstata (CaP) representa el segundo tumor en incidencia en hombres y es la quinta causa de muerte por cáncer a nivel global. El CaP es un tumor hormono-dependiente, que requiere de la activación del receptor de andrógenos (AR) para su proliferación. Clínicamente, se caracteriza por una gran variabilidad en su evolución, progresando desde una condición indolente hasta un fenotipo agresivo que puede diseminarse y metastatizar a los nodos linfáticos y huesos. Actualmente, el diagnóstico temprano del CaP se realiza mediante la determinación sérica del antígeno prostático específico (PSA) y el examen rectal digital (DRE). Si estas pruebas dan resultados anómalos y hay …

resonancia magnética nuclearesencialidad génicacáncer de próstatatherapeutic targetbiomarkersUNESCO::CIENCIAS TECNOLÓGICASprostate cancerdianas terapéuticasmetabolomicsnuclear magnetic resonancebiomarcadoresgene essentialityUNESCO::CIENCIAS MÉDICASmetabolómica
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Descripción del perfil metabólico de adenomas hipofisarios mediante espectroscopia "ex-vivo", por resonancia magnética de alta resolución con rotació…

2017

INTRODUCCION La técnica experimental de espectroscopia ex¬ vivo, mediante resonancia magnética de alta resolución con rotación al ángulo mágico, utilizada en el estudio de muestras intactas de tejidos biológicos, ha demostrado ser una herramienta útil para la obtención de datos relevantes acerca de su perfil metabólico. Como ejemplo, su aplicación al estudio de tumores gliales del sistema nervioso central, se ha trasladado a la clínica diaria y tiene un papel relevante en el manejo y toma de decisiones terapéuticas. Los adenomas hipofisarios son tumores frecuentes, con características biológicas que hacen de su diagnóstico y manejo una tarea compleja que requiere un abordaje multidisciplina…

resonanciahipófisisUNESCO::CIENCIAS MÉDICASmetabolómicaadenomasespectroscopia:CIENCIAS MÉDICAS [UNESCO]
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The Circularity of MSW in Urban Landscapes: An Evaluation Method for a Sustainable System Implementation

2022

The debate on the sustainable perspective of a circular economy and MSW (Municipal Solid Waste) management is no longer focused on the resolution of an emergency and on the pure technicality of creating efficient services. New light has been shed on the operational phase, as often unresolvable technical-environmental issues during service management lead to a state of decay, affecting urban vulnerability and users’ involvement. The research aims to develop an auxiliary tool for public administrations in planning a zero-waste future whilst enhancing the urban landscape. This study considers the perspective of virtuous management of the resource flow cycle along with evaluating implementable …

resource flowAHPRenewable Energy Sustainability and the Environmentmulti-criteria approachGeography Planning and DevelopmentMSW; circular metabolism; multi-criteria approach; resource flows; AHPBuilding and Constructioncircular metabolismManagement Monitoring Policy and LawMSWSustainability
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Lo Scibene di Palermo un monumento da restaurare

2018

«Io penso che in tal guisa abbandonato il monumento raro assai più della Cuba e della Zisa in pochi anni andrà distrutto, e non lascerà orma della sua esistenza, ciò tornerebbe a disonore dell’epoca nostra. Io sarei ardito d’intraprendere una illustrazione di sì alto interesse, ma trovo diversi ostacoli, e tra questi mezzi necessari per lavori preparatori di sgombro, scavo, e spatinamento, che non sono di poco importo. Farei a mio conto le spese dei ponti e le scale per le misurazioni, e tutt’altro per la pubblicazione delle tavole, e de’ ragionamenti, purché la commissione di antichità e belle arti fosse plausibile a caricarsi delle prime spese sul fondo d’altronde destinato a tal uopo. [……

restauro arabo normanno PalermoSettore ICAR/19 - Restauro
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Palermo. Un museo virtuale - Palermo. A virtual museum

2016

Conoscenza, conservazione e valorizzazione sono tra gli obiettivi principali delle discipline riguardanti il disegno, il rilievo e la restituzione grafica dell’architettura, che non si fermano soltanto alla documentazione dello stato di fatto ma comprendono anche ricostruzioni congetturali del processo diacronico di modificazione del monumento ai fini di una sua più ampia conoscenza; la storia del monumento si inserisce, in tal modo, nella storia della città e dei suoi cambiamenti culturali; queste nuove immagini sono veri e propri importanti elementi di un "virtual museum" del sito e, più in generale, della città sulla quale esso insiste. Da molti anni, ormai, i docenti, gli assegnisti di …

restituzione graficavirtual museumricostruzioni digitaliRedrawingmodelingrilievoSettore ICAR/17 - DisegnohistoryMuseo virtualearchitettura arabo-normannaPalermo
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Cholesterol homeostasis and retinal stress in anterior ischemic optic neuropathy

2016

Purpose: Anterior ischemic optic neuropathy (AION) is characterized by acute stress of retinal ganglion cells (RGC). Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in RGC where it may exert neuroprotective properties by preventing from cholesterol accumulation via catalyzing the formation of 24S-hydroxycholesterol. Previous findings hypothesize the housekeeping importance of CYP46A1 in the maintenance of cholesterol in the retina. In order to better understand the role of CYP46A1 in the retina, we aimed to define whether CYP46A1 expression and 24S-hydroxycholesterol levels were modified during RGC stress in AION.Methods: Ninety nine male Sprague Dawley rats were randomized …

retina[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutritionrétinecholestéroleye diseases[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology[ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organsbiomarkersense organscyp46a1[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organsmetabolismmétabolisme[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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Regulation of immune response in post-operative endophthalmitis

2011

Regulation of immune response in post-operative endophthalmitis. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)

retina[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]genetic structures[SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT]œilréponse immunitairebiochemical phenomena metabolism and nutritionimmunologic reactionseye diseasesendophtalmie[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organsinflammation[ SDV.MHEP.OS ] Life Sciences [q-bio]/Human health and pathology/Sensory Organsophthalmia[ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT][SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
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Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.

2003

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that mediate phospholipase D (PLD) activation in brain, but the mechanism underlying this response remains unclear. Here we used primary cultures of astrocytes as a cell model to explore the mechanism that links mGluRs to PLD. Glutamate activated both phospholipase C (PLC) and PLD with equal potency and this effect was mimicked by L-cysteinesulfinic acid, a putative neurotransmitter previously shown to activate mGluRs coupled to PLD, but not PLC, in adult brain. PLD activation by glutamate was dependent on Ca(2+) mobilization and fully blocked by both protein kinase C (PKC) inhibitors and PKC down-regulation, suggesti…

rho GTP-Binding ProteinsIndolesBacterial ToxinsGlutamic AcidBiologyReceptors Metabotropic GlutamateSulfenic AcidsMaleimidesRats Sprague-DawleyCellular and Molecular NeuroscienceBacterial ProteinsStress FibersmedicinePhospholipase DAnimalsCysteineEgtazic AcidProtein kinase CCells CulturedProtein Kinase CChelating AgentsPharmacologyProtein Synthesis InhibitorsBrefeldin APhospholipase CDose-Response Relationship DrugEndothelin-1Phospholipase DADP-Ribosylation FactorsMetabotropic glutamate receptor 6Glutamate receptorDNAMolecular biologyRatsenzymes and coenzymes (carbohydrates)medicine.anatomical_structureMetabotropic receptorMetabotropic glutamate receptorAstrocytesType C PhospholipasesTetradecanoylphorbol Acetatelipids (amino acids peptides and proteins)AstrocyteNeuropharmacology
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CONOSCENZA E CONSERVAZIONE. PROSPETTIVE PER LE DOMUS DI PIAZZA DELLA VITTORIA A PALERMO.

2014

Il tema di ricerca possiede un carattere multidisciplinare, coinvolge ampi settori e, con un approccio metodologico di tipo olistico, mette in evidenza le complessità storiche, artistiche, architettoniche, archeologiche e urbanistiche, tenendo conto delle differenti implicazioni sul piano sia tecnologico che museografico. Il caso di studio scelto, per elaborare una strategia d’intervento e riproponibile in altri contesti, è costituito dalle Domus di Piazza della Vittoria a Palermo, un exemplum di complesso residenziale unico nell’ambito della città, arricchito dalla presenza di importanti mosaici che testimoniano la circolazione di possibili culti praticati nell’area occidentale della Sicil…

ricerca archeologicaknowledgeconservazioneconservationarchaeological data processingdocumentation of findsarchaeological heritagevalorizzazioneSettore ICAR/12 - Tecnologia Dell'Architetturapatrimonio archeologicoelaborazione dati archeologiciconoscenzaarchaeological researchdocumentazione repertivalorization
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La prise en compte de la stratégie agricole améliore la compréhension de l’effet des pratiques sur les communautés adventices

2019

National audience; Les agriculteurs présents dans une même situation de production peuvent différer dans leurs objectifs et donc leurs pratiques. Afin de tester l’effet d’une pratique particulière (ex. désherbage chimique) sur la communauté adventice, il est donc nécessaire de tenir compte de l’ensemble des autres pratiques, formant une stratégie agricole. Nous avons ainsi développé 14 indicateurs décrivant les pratiques agricoles enquêtées sur la zone de Fénay de 2004 à 2016 auprès des 23 agriculteurs de la zone. L’originalité des indicateurs est qu’ils situent chaque parcelle par rapport aux autres parcelles ayant mis en oeuvre la même culture la même année sur la zone. Ceci nous a permis…

richesse spécifique[SDE] Environmental Sciencesabundance[SDV]Life Sciences [q-bio]speciesenquêtetravail du sol[SDV] Life Sciences [q-bio]abondance;herbicide[SDE]Environmental Sciencestillage[SDV.BV]Life Sciences [q-bio]/Vegetal Biologysurvey[SDV.BV] Life Sciences [q-bio]/Vegetal Biologyrichness
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