Search results for "ACAT"

showing 10 items of 96 documents

Corresponding doses of mometasone furoate (MF) in once-daily inhaled fixed-dose combination (FDC) of indacaterol/mometasone furoate (IND/MF) and inda…

2021

business.industryImmunologyFixed-dose combinationmedicineImmunology and AllergyIndacaterolMometasone furoateOnce dailyPharmacologybusinessmedicine.drugJournal of Allergy and Clinical Immunology
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1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes.

2010

Selected biological effects of 1,4-naphthoquinone, menadione (2-methyl-1,4-naphthoquinone) and structurally related quinones from natural sources--the 5-hydroxy-naphthoquinones juglone, plumbagin and the 2-hydroxy-naphthoquinones lawsone and lapachol--were studied in human keratinocytes (HaCaT). 1,4-naphthoquinone and menadione as well as juglone and plumbagin were highly cytotoxic, strongly induced reactive oxygen species (ROS) formation and depleted cellular glutathione. Moreover, they induced oxidative DNA base damage and accumulation of DNA strand breaks, as demonstrated in an alkaline DNA unwinding assay. Neither lawsone nor lapachol (up to 100 microM) were active in any of these assay…

chemistry.chemical_classificationKeratinocytesReactive oxygen speciesDose-Response Relationship DrugDNA damageBiophysicsPlumbaginBiochemistryMolecular biologyLawsoneCell Linechemistry.chemical_compoundHaCaTOxidative StresschemistryMenadioneBiochemistryHumansReactive Oxygen SpeciesMolecular BiologyJugloneLapacholNaphthoquinonesSignal TransductionArchives of biochemistry and biophysics
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Characterization of Nanostructured SilicaCat Pd0

2011

Structural investigation on nanostructured SiliaCat Pd0 palladium catalyst sheds light into the origins of the remarkable activity of these new catalytic materials.

chemistry.chemical_elementNanoparticleGeneral ChemistryOrmosilCatalysisCharacterization (materials science)Catalysischemistry.chemical_compoundchemistryChemical engineeringPalladium ORMOSIL SiliaCat Cross-coupling NanoparticlePalladium catalystOrganometallic chemistryPalladium
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Il tramonto della full jurisdiction per gli antitrust infringements: la chiusura italiana ai principi dettati dalla Corte europea dei diritti dell'uo…

2018

L'articolo affronta alcune rilevanti questioni riguardanti il tema dell'adeguamento del vigente sistema di tutela giurisdizionale rispetto alla giurisprudenza della Corte europea dei diritti dell'uomo in merito all'art. 6 della Cedu. In primo luogo, vengono analizzati i principi sanciti dalla Corte in ordine alla natura giuridica e all'applicazione delle sanzioni amministrative; in secondo luogo, viene evidenziato come il giudice amministrativo esercita il suo sindacato nei confronti delle predette sanzioni, con particolare riferimento agli illeciti antitrust. Infine, si traggono le conclusioni in merito alla compatibilità dell'attuale quadro normativo nazionale rispetto agli orientamenti f…

giusto processosindacato del giudice amministrativoConcorrenzaSettore IUS/10 - Diritto Amministrativogaranzie di difesanatura sanzionatoriasanzioni amministrative
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Recensione a E.C. IP, Judging Regulators. The Political Economy of Anglo-American Administrative Law, Cheltenham, Edward Elgar, 2020

2021

E' una recensione al libro di Eric C. IP, Judging Regulators. The Political Economy of Anglo-American Administrative Law it is a review of the book written by Eric C. Ip, Judging Regulators. The Political Economy of Anglo-American Administrative Law

judicial review administrative actionsindacato giuridizionale azione amministrativaSettore IUS/10 - Diritto Amministrativo
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El juramento o promesa de acatamiento del estatuto de autonomía en las corporaciones locales y el uso de fórmulas imaginativas

2021

El art. 23 Constitución Española, consagra el derecho fundamental al sufragio activo y pasivo, y lo hace, respecto al sufragio pasivo, en su apartado 2º: “Asimismo, tienen derecho a acceder en condiciones de igualdad a las funciones y cargos públicos, con los requisitos que señalen las leyes”. La configuración legal del derecho fundamental al acceso a los cargos públicos determina que los requisitos para tal acceso deban estar previstos en normas de rango legal. Tal exigencia deviene tanto por la específica previsión del art. 23.2 CE, como por la aplicación del principio de reserva de ley del art. 53.1 CE: “Los derechos y libertades reconocidos en el Capítulo segundo del presente Título vin…

juramento o promesa de acatamientoentidades localesderecho de sufragio pasivoUNESCO::CIENCIAS JURÍDICAS Y DERECHO
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Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes.

2001

The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and ACAT, the major enzymes involved in cholesterol metabolism, were determined in macrosomic offspring of streptozotocin-induced diabetic rats. Hepatic, serum, and lipoprotein cholesterol contents were also examined. Mild hyperglycemia in pregnant rats was induced by intraperitoneal injection of streptozotocin (40 mg/kg body weight) on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At birth, macrosomic pups had higher serum, LDL-HDL1, and H…

medicine.medical_specialtyOffspringmedicine.medical_treatmentLipoproteinsLCATIntraperitoneal injectionQD415-436GrowthReductaseBiologyBiochemistryStreptozocinDiabetes Mellitus ExperimentalFetal MacrosomiaPhosphatidylcholine-Sterol O-Acyltransferasechemistry.chemical_compoundEndocrinologyHMG-CoA reductasePregnancyInternal medicineDiabetes mellitusmedicineAnimalsmacrosomiaRats Wistarmaternal diabetesCholesterol 7-alpha-Hydroxylasecholesterol 7α-hydroxylaseCholesterolCell Biologymedicine.diseaseStreptozotocinAcetyl-CoA C-AcyltransferaseHydroxymethylglutaryl-CoA reductaseACATRatsEndocrinologyCholesterolchemistryLiverHydroxymethylglutaryl-CoA-Reductases NADP-dependentHyperglycemiaPrenatal Exposure Delayed EffectsGestationPregnancy Animallipids (amino acids peptides and proteins)FemaleHydroxymethylglutaryl CoA Reductasesmedicine.drugJournal of lipid research
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Indacaterol Provides Effective Bronchodilation In Patients With Chronic Obstructive Pulmonary Disease Irrespective Of Patient Age (<65 Or e65 Year…

2010

medicine.medical_specialtyPatient agebusiness.industryInternal medicineBronchodilationmedicineCardiologyIndacaterolPulmonary diseaseIn patientbusinessmedicine.drugC41. EMERGING PHARMACOLOGY FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE: MECHANISMS AND OUTCOMES
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Mometasone furoate delivered via Breezhaler and Twisthaler in patients with asthma

2019

Introduction: Mometasone furoate (MF), an inhaled corticosteroid (ICS), is approved for the treatment of asthma. Previous studies suggest that MF Twisthaler® doses of 800 and 200 µg and MF Breezhaler® doses of 320 and 80 µg would elicit similar lung function effects, respectively. These MF doses are also used in an indacaterol/MF combination in development for asthma. Since sensitivity to ICS is variable, individual patients’ ICS sensitivity (as measured by FEV1 decline on ICS weaning) was used to build a robust analysis model for the study data. Methods: This was a randomized, double-blind, double-dummy, parallel-group, non-inferiority study of 739 adolescents and adults with asthma. MF wa…

medicine.medical_specialtybusiness.industrymedicine.drug_classUrologyMometasone furoatemedicine.diseaseDermatologyMean difference03 medical and health sciences0302 clinical medicine030228 respiratory systemMedicineIndacaterolCorticosteroidIn patient030212 general & internal medicinebusinessRobust analysisLung functionmedicine.drugAsthmaAirway pharmacology and treatment
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Determination of Optimum Prices in the Commercial Distribution Sector in Spain: Application of an Asymetrical Competition Approach

2011

Teniendo en cuenta la importancia que adquieren las decisiones de precios en la distribución comercial minorista, en este trabajo se propone un modelo de decisión de precios óptimos en el que, a corto plazo, los efectos de los precios óptimos sobre la demanda y los márgenes del distribuidor maximizan la rentabilidad global de la categoría de productos. Tres aspectos fundamentales permiten describir esta propuesta: 1) se basa en una perspectiva agregada; 2) incorpora modelos de cuota de mercado con consistencia lógica -con el fin de aportar mayor robustez a la medición de la demanda- y 3) incluye el papel de la estructura competitiva mediante una modelización explícita de los efectos asimétr…

optimisation de prixPrice optimizationstructure compétitive intra catégorieotimização de preçosestructura competitiva intracategoríaintra-category competitive structureoptimización de preciosestrutura competitiva intracategoria
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