Search results for "ACID"
showing 10 items of 13107 documents
Genome size evolution in macroparasites.
2014
Reduction in genome size has been associated not only with a parasitic lifestyle in intracellular microparasites but also in some macroparasitic insects and nematodes. We collected the available data on genome size for flatworms, annelids, nematodes and arthropods, compared those with available data for the phylogenetically closest free-living taxa and found evidence of smaller genome sizes for parasites in six of nine comparisons. Our results suggest that despite great differences in evolutionary history and life cycles, parasitism as a lifestyle promotes convergent genome size reduction in macroparasites. We discuss factors that could be associated with small genome size in parasites whic…
Evidence of Weak Halogen Bonding: New Insights on Itraconazole and its Succinic Acid Cocrystal
2012
Exact knowledge of the crystal structure of drugs and lead compounds plays a significant role in the fields of crystal engineering, docking, computational modeling (drug–receptor interactions), and rational design of potent drugs in pharmaceutical chemistry. The succinic acid cocrystal of the systemic antifungal drug, itraconazole, reported by Remenar et al. (J. Am. Chem. Soc.2003, 125, 8456–8457) (CSD: IKEQEU), represents one of the classical examples displaying a molecular fitting mechanism in the solid state. In this work, we disclose the X-ray single-crystal structure of the cis-itraconazole–succinic acid (2:1) cocrystal and found that it differs slightly from the previously reported st…
SERS detection of cell surface and intracellular components of microorganisms using nano-aggregated Ag substrate
2016
Abstract The intracellular and cell surface composition and structural features of gram-positive and gram-negative bacteria were identified using near-infrared surface-enhanced Raman scattering (SERS). The structural differences of components that reside in the cell envelope are manifested by their SERS spectra, e.g. gram-negative vs. gram-positive. Silver particles were used as a SERS substrate by exploiting the existence of strong local electromagnetic fields (hot spots) within nanoscale aggregates of the particles. The aggregation of silver nanoparticles was induced by magnesium ions. These hot spots reduce the screening length of the double layer. The obtained SERS spectra showed excell…
Alumnos con NNEE : la alta capacidad intelectual
2013
El siguiente trabajo de investigación, es una propuesta realizada por un alumno de 4º año de Magisterio de la Universidad de Valencia. La propuesta forma parte del TFG (Trabajo de Fin de Grado) del Grado de Maestro en Educación Primaria. A través de la investigación, se pretende demostrar que el hecho de recibir algún tipo de atención diferenciada, tomando las medidas adecuadas a su capacidad intelectual, tiene repercusiones positivas sobre el alumnado. En este caso en particular, se analizará si los alumnos con un diagnóstico en A.C. (Altas Capacidades) se ven beneficiados tanto a nivel emocional como académico, cuando se pone en práctica una buena medida escolar. The following research wo…
A method for anthocyanin extraction from fresh grape skin
2003
Task-Specific Organic Salts and Ionic Liquids Binary Mixtures: A Combination to Obtain 5-Hydroxymethylfurfural From Carbohydrates
2019
The increase in energy demand and depletion of fossil fuels are among major issues of modern society. Valorization and transformation of raw materials in products of industrial value represents a challenge. This justifies the growing interest of scientific research towards the identification of suitable media and methodologies able to pursue above goals, paying attention to matter of sustainability. On this subject, we studied sulfonic-acid functionalized diimidazolium salts as catalysts for the conversion of fructose and sucrose to 5-hydroxymethylfurfural (5-HMF) in an ionic liquid mixture. In general, using these salts allowed us to obtain 5-HMF in good yields from both substrates in mild…
Taste receptors signalling
2010
International audience
Piecing together the taste signaling puzzle
2010
International audience; The identification of the genes coding for bitter, umami, sweet and sour taste receptors has provided us with unique tools to investigate the gustatory system. As a consequence, tremendous progress towards our understanding of the functional organization of the peripheral taste system has been achieved over the past decade. In particular, key components of the taste receptors signaling cascades have been identified as well as populations of chemosensory cells in the olfactory, respiratory and digestive systems expressing taste receptors. Besides sharing receptors and signaling molecules (gustducin, phospholipase-C b2…) with taste bud cells, these cells display a simi…
Efectos del capital psicológico en el comportamiento innovador
2013
Este trabajo analiza el impacto del Capital Psicológico del líder sobre el Comportamiento Innovador de los colaboradores en la organización, estableciendo la influencia que en ello tienen los factores Capacidad de Aprendizaje Organizacional y Apoyo o Intercambio entre los miembros del Equipo (Team Member Exchange). El Capital Psicológico, un constructo de segundo orden que incorpora los recursos psicológicos positivos, eficacia, esperanza, optimismo y resiliencia, tiene la posibilidad de construirse sobre el individuo, a diferencia de otros rasgos de la personalidad que normalmente son permanentes en el tiempo, permitiendo a la organización un desarrollo continuado y un impacto favorable en…
LAS COMPETENCIAS DEL PROFESORADO EN TIC: ESTRUCTURA BÁSICA
2013
Las competencias en TIC del profesorado son una variable clave para la integración de las TIC en la escuela. Este artículo presenta un esquema de indicadores de competencia para dos dimensiones, competencias tecnológicas y competencias pedagógicas, desde un modelo MIMIC. El modelo incluye la definición de una relación específica entre estas dimensiones y también de los efectos de un conjunto de factores relevantes: personales (género, edad y frecuencia de uso del ordenador) y contextuales (tipo de centro, etapa educativa y acceso al aula de informática). La información se recogió mediante un cuestionario aplicado a una muestra de 868 profesoras y profesores de educación primaria y secundari…