Search results for "ADAM"

Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of…

2021

Abstract Brain-derived neurotrophic factor (BDNF) is an important modulator for a variety of functions in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and protein level in the brain, cerebrospinal fluid (CSF), and blood samples of Alzheimer’s disease (AD) patients implicates a crucial role of BDNF in the progression of this disease. Especially, processing and subcellular localization of BDNF and its receptors TrkB and p75 are critical determinants for survival and death in neuronal cells. Similarly, the amyloid precursor protein (APP), a key player in Alzheimer’s disease, and its cleavage fragments sAPPα and Aβ are known for their respective roles in neuropro…

Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants

2016

Background: Alzheimer’s disease is one of the most prevalent dementias in the elderly population with increasing numbers of patients. One pivotal hallmark of this disorder is the deposition of protein aggregates stemming from neurotoxic amyloid-beta peptides. Synthesis of those peptides has been efficiently prevented in AD model mice by activation of an enzyme called alpha-secretase. Therefore, drugs with the capability to increase the expression of this enzyme, named ADAM10, have been suggested as a valuable therapeutic medication. Methods: We investigated 69 substances from a drug library derived from traditional Chinese medicine by luciferase reporter assay in human neuronal cells for th…

Adam Smith and Gaetano Filangieri. Two alternatives face of enlightenment science of legislator

2017

The article proposes a comparison between the thought and works of Adam Smith and Gaetano Filangieri, two of the greatest exponents of European Enlightenment. We can find some important coincidences in their profiles. Smith and Filangieri met with outstanding international success and their works were translated into most known languages. Both were the main representative scholars of their respective schools: Scottish and the Neapolitan. Each of them planned to write a great work concerning the science of legislator but they died before completing it. Despite these resemblances, a deep difference is evident in their thought which makes their works paradigmatic of two different scientific vi…

"Penso a Turandot non finita!". Riflessioni sul capolavoro incompiuto di Giacomo Puccini

2019

Il saggio ricostruisce gli ultimi mesi della vita di Giacomo Puccini, con particolare riferimento alla composizione del terzo atto di "Turandot", agli abbozzi lasciati dall'autore al momento della morte (Bruxelles 1924) e ai successivi interventi compositivi e di orchestrazione realizzati da Franco Alfano.

Histoire de Madame de Mucie : une épouse de parlementaire dijonnais héroïne de roman galant

2017

International audience

Multifocal aplasia cutis congenita, distal limb hemimelia, and cutis marmorata telangiectatica in a patient with Adams-Oliver syndrome.

1992

Summary We describe an 18-month-old boy with multifocal scalp defects over the posterior parietal region combined with an underlying defect of the skull, left lower limb distal hemimelia and generalized cutis marmorata telangiectatica, consistent with a diagnosis of Adams–Oliver syndrome (aplasia cutis congenita with distal transverse limb defects).

Chemistry and reactivity of dinuclear iron oxamate complexes: alkane oxidation with hydrogen peroxide catalysed by an oxo-bridged diiron(III) complex…

2004

[EN] A new dinuclear iron(III) complex with the tetradentate ligand N,N'-o-phenylenebis(oxamate) (opba) has been synthesised, and structurally, magnetically and electrochemically characterised. It possesses an unprecedented triply bridged Fe-2(mu-O)(mu-RCO2...H2O...O2CR)(2) core, whereby two N-amides from the opba ligand complete the square-pyramidal coordination sphere of the O-carboxylate rich iron site (Fe-N = 2.053 Angstrom and Fe-O = 2.015 Angstrom), The antiferromagnetic exchange interaction between the two high-spin Fe-III ions through the oxo bridge (J = -190 cm(-1); H = -JS(1)(.)S(2)) is weaker than that found in related mu-oxo singly bridged diiron(III) complexes. The lessened ant…

Leikki kulttuuri-ilmiönä ja antropologisena käsitteenä : filosofis-antropologinen tutkielma leikki-käsitteen vaikutushistoriasta

2001

I disegni dall’antico di Giuseppe Venanzio Marvuglia

2007

Il saggio è il risultato di una lunga ricerca anche con indagini archivistiche nell’ambito di un PRIN con fondi MIUR 2004-2006, dal titolo Progettare la memoria. Architettura e monumento in Italia tra secondo Settecento e primo Novecento, coordinatore nazionale prof. Fabio Mangone, coordinatore locale prof. Maria Giuffrè. L’incrocio tra le fonti primarie e secondarie, tra le prime un intenso lavoro presso archivi locali, ha consentito di reinquadrare in maniera del tutto innovativa la biografia dell’architetto palermitano Giuseppe Venanzio Marvuglia (1729-1814), uno dei principali interpreti dell’architettura neoclassica in Italia fino ai neostili, e, in particolare, il suo cosiddetto “peri…

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis

2015

AbstractAmphiregulin (AR) involvement in liver fibrogenesis and hepatic stellate cells (HSC) regulation is under study. Non-alcoholic fatty liver disease (NAFLD) and its more severe form non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular cancer (HCC). Our aim was to investigate ex vivo the effect of AR on human primary HSC (hHSC) and verify in vivo the relevance of AR in NAFLD fibrogenesis. hHSC isolated from healthy liver segments were analyzed for expression of AR and its activator, TNF-α converting enzyme (TACE). AR induction of hHSC proliferation and matrix production was estimated in the presence of antagonists. AR involvement in fibrogenesis was also ass…