Search results for "ADAM"

Catalytic Oxidation of Alkanes and Alkenes by H 2 O 2 with a μ‐Oxido Diiron(III) Complex as Catalyst/Catalyst Precursor

2015

A new mu-oxo diiron(III) complex of the lithium salt of the pyridine-based unsymmetrical ligand 3-[(3-{[bis(pyridin-2-ylmethyl)amino]methyl}-2-hydroxy-5-methylbenzyl)(pyridin2-ylmethyl)amino] propanoate (LiDPCPMPP), [Fe-2(mu-O)(LiDPCPMPP)(2)](ClO4)(2), has been synthesized and characterized. The ability of the complex to catalyze oxidation of several alkanes and alkenes has been investigated by using CH3COOH/H2O2 (1:1) as an oxidative system. Moderate activity in cyclohexane oxidation (TOF = 33 h(-1)) and good activity in cyclohexene oxidation (TOF = 72 h(-1)) were detected. Partial retention of configuration (RC = 53%) in cis- and trans-1,2-dimethylcyclohexane oxidation, moderate 3 degrees…

Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins.

2001

The L1 adhesion molecule plays an important role in axon guidance and cell migration in the nervous system. L1 is also expressed by many human carcinomas. In addition to cell surface expression, the L1 ectodomain can be released by a metalloproteinase, but the biological function of this process is unknown. Here we demonstrate that membrane-proximal cleavage of L1 can be detected in tumors and in the developing mouse brain. The shedding of L1 involved a disintegrin and metalloproteinase (ADAM)10, as transfection with dominant-negative ADAM10 completely abolishes L1 release. L1-transfected CHO cells (L1-CHO) showed enhanced haptotactic migration on fibronectin and laminin, which was blocked …

The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity

2005

The cellular prion protein (PrP(c)) is physiologically cleaved in the middle of its 106-126 amino acid neurotoxic region at the 110/111 downward arrow112 peptidyl bond, yielding an N-terminal fragment referred to as N1. We recently demonstrated that two disintegrins, namely ADAM10 and ADAM17 (TACE, tumor necrosis factor alpha converting enzyme) participated in both constitutive and protein kinase C-regulated generation of N1, respectively. These proteolytic events were strikingly reminiscent of those involved in the so-called "alpha-secretase pathway" that leads to the production of secreted sAPPalpha from betaAPP. We show here, by transient and stable transfection analyses, that ADAM9 also…

Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulat…

2003

Tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) is a member of the ADAM (a disintegrin and metalloproteinase) family of type I membrane proteins and mediates the ectodomain shedding of various membrane-anchored signaling and adhesion proteins. TACE is synthesized as an inactive zymogen, which is subsequently proteolytically processed to the catalytically active form. We have identified the proprotein-convertases PC7 and furin to be involved in maturation of TACE. This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells. Furthermore…

Fleabag's Ethical Investigations

2020

Fleabag is a television series created and written by Phoebe Waller-Bridge, who also stars as the eponymous character. The television series was produced by Two Brothers Pictures and consists of two seasons of six episodes, each lasting around 25 minutes; the first season (2016) was produced for BBC Three whilst the second season (2019) for BBC Three and for Amazon Studios. Fleabag has conquered the heart of audiences all over the world, has received universal critical acclaim, has been presented with many accolades, and has been awarded several prizes. I see Fleabag as a primer on ethics, a compendium of some relevant themes of moral philosophy. The two-season television series is steeped …

Bombas y democracia

2003

Gozos á la gloriosa santa Elena Emperatriz, madre del Emperador Constantino, que se venera en la Iglesia Parroquial de Santa Cruz.

El full orlat Grav. enmarcat de "Santa Elena", flanquejat per gerros amb flors Text del goig a tres col. separades per filets

On the additivity of block designs

2016

We show that symmetric block designs $${\mathcal {D}}=({\mathcal {P}},{\mathcal {B}})$$D=(P,B) can be embedded in a suitable commutative group $${\mathfrak {G}}_{\mathcal {D}}$$GD in such a way that the sum of the elements in each block is zero, whereas the only Steiner triple systems with this property are the point-line designs of $${\mathrm {PG}}(d,2)$$PG(d,2) and $${\mathrm {AG}}(d,3)$$AG(d,3). In both cases, the blocks can be characterized as the only k-subsets of $$\mathcal {P}$$P whose elements sum to zero. It follows that the group of automorphisms of any such design $$\mathcal {D}$$D is the group of automorphisms of $${\mathfrak {G}}_\mathcal {D}$$GD that leave $$\mathcal {P}$$P in…

New spaces of matrices with operator entries

2019

In this paper, we will consider matrices with entries in the space of operators $\mathcal{B}(H)$, where $H$ is a separable Hilbert space and consider the class of matrices that can be approached in the operator norm by matrices with a finite number of diagonals. We will use the Schur product with Toeplitz matrices generated by summability kernels to describe such a class and show that in the case of Toeplitz matrices it can be identified with the space of continuous functions with values in $\mathcal B(H)$. We shall also introduce matriceal versions with operator entries of classical spaces of holomorphic functions such as $H^\infty(\mathbb{D})$ and $A(\mathbb{D})$ when dealing with upper t…

Smithian Growth and Complexity

2016

In this paper we argue that Adam Smith’s theory of division and labor and economic growth, in particular through the developments of Alfred Marshall, Allyn Young and Nicholas Kaldor, has characteristics that allow to classify it in the realm of complexity economics. We support this claim by a historical reconstruction of the Smithian growth theory highlighting the characteristics that we show also characterize complex systems. We compare this perspective with the one developed by the traditional economic approach, rooted in general equilibrium, and describe a simple alternative model