Search results for "ADCP"
showing 4 items of 4 documents
Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma
2018
Multiple myeloma (MM) is a bone marrow plasma cell neoplasm and is the second most-common hematologic malignancy. Despite advances in therapy, MM remains largely incurable. Elotuzumab is a humanized IgG1 monoclonal antibody targeting SLAMF7, which is highly expressed on myeloma cells, and the antibody is approved for the treatment of relapsed and/or refractory (RR) MM in combination with lenalidomide and dexamethasone. Elotuzumab can stimulate robust antibody-dependent cellular cytotoxicity (ADCC) through engaging with FcγRIIIA (CD16) on NK cells and antibody-dependent cellular phagocytosis (ADCP) by macrophages. Interestingly, SLAMF7 is also expressed on cytolytic NK cells, which also expr…
Acoustic and optical variations during rapid downward motion episodes in the deep north-western Mediterranean Sea
2011
An Acoustic Doppler Current Profiler (ADCP) was moored at the deep-sea site of the ANTARES neutrino telescope near Toulon, France, thus providing a unique opportunity to compare high-resolution acoustic and optical observations between 70 and 170 m above the sea bed at 2475 m. The ADCP measured downward vertical currents of magnitudes up to 0.03 m s-1 in late winter and early spring 2006. In the same period, observations were made of enhanced levels of acoustic reflection, interpreted as suspended particles including zooplankton, by a factor of about 10 and of horizontal currents reaching 0.35 m s-1. These observations coincided with high light levels detected by the telescope, interpreted …
The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
2021
Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indications. In order to ensure clinical efficacy and safety aspects, (pre-)clinical experimental approaches evaluate the respective modes of action (MoA). In addition to antigen-specificity including binding affinity and -avidity, MoA comprise Fc-mediated effector functions such as antibody dependent cellular cytotoxicity (ADCC) and the closely related antibody dependent cellular phagocytosis (ADCP). For this reason, a variety of cell-based assays have…
Automaattisten mittalaitteiden käyttö vesistöseurannassa : esimerkkinä Jyväsjärven tutkimuslautta Aino
2011
Vesistöseurannan automatisointi lisää huomattavasti saatavilla olevan tiedon määrää, mutta samalla automaattisten aineistojen laadunvarmennuksen tärkeys korostuu. Jyväskylän yliopiston tutkimuslautta Aino mittaa jatkuvatoimisesti mm. veden happipitoisuuden ja lämpötilan vertikaaliprofiilia Jyväsjärvellä. Lautan tulosten luotettavuutta tutkittiin automaattisten mittalaitteiden sekä manuaalisen mittauksen avulla. Lautalla mitattiin myös virtausten suuntaa ja nopeutta ADCP-virtausmittarilla. Virtaustiedot tarkensivat kerrostumisen purkautumisen kuvaamiseen käytettyjä lukuja. Eri mittalaitteiden tuottamat happipitoisuustulokset poikkesivat merkitsevästi toisistaan. Hapen automaattisessa mittaam…