Search results for "ADE"
showing 10 items of 15269 documents
Expression of 60-kD Heat Shock Protein Increases during Carcinogenesis in the Uterine Exocervix
2002
<i>Objectives:</i> The aim of the present study was to determine the presence and expression of the 60-kD heat shock protein (HSP60) in the dysplasia-carcinoma sequence in the uterine exocervix and to evaluate its diagnostic and prognostic significance. <i>Methods and Results:</i> We performed Western blot and immunohistochemical analyses on biopsies from 40 cases, consisting of 10 normal exocervical biopsies, 10 low-grade squamous intraepithelial lesions (L-SIL), 10 high-grade squamous intraepithelial lesions (H-SIL) and 10 cancerous exocervices (G2 grade). The immunohistochemical results were quantified by computer-assisted image analysis. Western blot analysis sho…
COX-2 expression in chondrosarcoma: A role for celecoxib treatment?
2010
Chondrosarcomas are resistant to conventional chemo- and radiotherapy. A subset of chondrosarcomas arises secondarily in the benign tumour syndromes enchondromatosis (EC) and multiple osteochondromas (MO), and prevention of tumour development would greatly improve prognosis. We therefore investigated the effect of selective COX-2 inhibition on chondrosarcoma growth. COX-2 expression was studied in central- and peripheral cartilaginous tumours. The effect of COX-2 inhibition was assessed in four high-grade chondrosarcoma cell lines using celecoxib and NS-398 treatment. COX-2 activity (prostaglandin E-2 (PGE(2)) ELISA) and cell viability were measured. The (prophylactic) effect of celecoxib o…
Modulation of type II collagen-induced arthritis in DBA/1 mice by intravenous application of a peptide from the C1q-A chain.
1992
In this report we are able to show that intravenous (i.v.) application (day 0) of a nonapeptide (residues 26-34) from the human C1q A-chain (designated peptide A-C1q) prior to intradermal (i.d.) administration of chicken type II collagen (CII) in arthritis-susceptible DBA/1 mice (H2q), leads to abrogation of polymorphonuclear neutrophil (PMN) invasion into the joints. This nonapeptide exhibits epitope characteristics and high homology to residues 137-147 of CB11 (a cyanogen bromide fragment of chicken CII, known to contain both arthritis inducing and suppressing determinants). Arthritis index was lowest in animals pretreated i.v. with CII (as internal control), though animals pretreated i.v…
M-mode Ultrasound Examination of Soleus Muscle in Healthy Subjects: Intra- and Inter-Rater Reliability Study
2020
Objective: M-mode ultrasound imaging (US) reflects the motion of connective tissue within muscles. The objectives of this study were to evaluate inter-rater and intra-rater reliability of soleus muscle measurements between examiners with different levels of US experience in asymptomatic subjects and to investigate the level of soleus muscle isometric activity in two positions (knee extended and knee flexed at 30°
The Epidemiology of Hip and Knee Primary and Revision Arthroplasties during the COVID-19 Pandemic
2021
Background: The purpose of this study was to provide a comprehensive assessment of the impact of the COVID-19 pandemic on the epidemiology of primary and revision arthroplasties of the hip and knee joint. Methods: This study compared the data on knee and hip arthroplasty procedures from 2 hospitals (primary and revision) conducted in two periods: the period of the COVID-19 pandemic in Poland (from 4 March 2020 to 15 October 2020) and the corresponding period prior to the pandemic (from 4 March 2019 to 15 October 2019). We compared the epidemiological data, demographic data, and hospital stay duration data from these two periods. Results: Our analysis demonstrated that the total number of hi…
Comparison of Postoperative Coronal Leg Alignment in Customized Individually Made and Conventional Total Knee Arthroplasty
2021
Neutral coronal leg alignment is known to be important for postoperative outcome in total knee arthroplasty (TKA). Customized individually made implants (CIM) instrumented with patient-specific cutting guides are an innovation aiming to increase the precision and reliability of implant positioning and reconstruction of leg alignment. We aimed to compare reconstruction of the hip–knee–ankle angle (HKA) of the novel CIM system iTotal™ CR G2 (ConforMIS Inc.) to a matched cohort of the off-the-shelf (OTS) knee replacement system Vanguard™ CR (Zimmer Biomet). Retrospective analysis of postoperative coronal full-leg weight-bearing radiographs of 562 TKA (283 CIM TKA, 279 OTS TKA) was conducted. V…
El periplo del objeto mitológico: itinerarios simbólicos del arte prehispánico entre los siglos XVI y XX
2014
Resumen : El presente texto discute la “identidad” que los objetos de arte prehispanico adquirieron desde el siglo XVI hasta mediados del siglo XX de acuerdo a los circuitos que recorrieron y los sujetos que los coleccionaron, miraron y pensaron. Itinerarios concretos: del contexto ritual al gabinete de curiosidades, del gabinete al museo arqueologico, del museo arqueologico a la muestra en espacios de arte. Itinerario que expresa las significaciones que el moderno Occidente les asigno en relacion a sus propias necesidades, anhelos y carencias. --------------------------- Abstract : This text discusses the "identity" that pre-Hispanic art objects acquired from the sixteenth to the twentieth…
«Sabiats que us diray en riman». Prime considerazioni sul rapporto tra forma, comunicazione e pubblico nella Lògica del Gatzell di Ramon Llull
2022
La Lògica del Gatzell, primo esempio della produzione in volgare di Ramon Llull, è un compendio in versi basato sull’opera di al-Ghazali Maqasid al-falasifah e sul Tractatus di Pietro Ispano, cui il Beato aggiunse alcuni elementi del suo personale sistema di pensiero. Insieme alla versione latina, il Compendium logicae Algazelis, evidenzia l’intenzione di Llull di promuovere lo studio dei principi fondamentali della filosofia proponendo due diversi sussidi didattici, ciascuno pensato per un determinato genere di pubblico. Il compendio rimato era indirizzato a coloro che non conoscevano il latino e per questo l’autore ricorse a una forma letteraria e a una strategia comunicativa tipiche dell…
Mythologie in Musicis: La alegoría sonora en el Anubis-Nout de Gérard Grisey
2011
El presente artículo plantea un acercamiento a la noción de alegoría sonora a partir de una retrospectiva panorámica de los principios estéticos y del corpus composicional del compositor francés Gérard Grisey, y concretamente de su díptico Anubis-Nout (1983) para clarinete contrabajo solo. La referencia a la mitología egipcia y su simbología no es el único punto de partida explícito de este réquiem posmoderno escrito a la memoria del compositor canadiense Claude Vivier, amigo del autor, a quien está dedicada la pieza, que fue asesinado brutalmente en circunstancias extrañas; muy al contrario, dichas referencias constituyen la fuente de una serie de alegorías asociativas especialmente relaci…
Aproximación al concepto de doble audiencia en la música de los largometrajes de Disney: Cinderella
2013
Si hay un sello que se ha convertido en un referente universal ha sido Disney que desde el inicio de la década de los veinte (1921) ha venido creando largometrajes y cortometrajes de animación así como películas tradicionales (no de animación). La utilización del concepto meramente literario del lector modelo, del lector intermediario y del doble modelo de lector sirven como base para hacer el análisis musical de la película de animación Cinderella de Disney. Se pretende esclarecer si también existen rasgos diferenciales en el tratamiento que hace Disney de la música atendiendo a este doble modelo de audiencia. Para ello, se llevó a cabo un análisis de la música tanto incidental como diegét…