Search results for "ADE"
showing 10 items of 15269 documents
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.
2005
Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …
Predictive value of p53, Ki67 and TLR5 in neoplastic progression of Barrett’s esophagus: a matched case–control study
2022
Abstract Barrett’s esophagus progresses to high-grade dysplasia or cancer along the well-established metaplasia-dysplasia-adenocarcinoma sequence. The aim of this study was to evaluate the value of p53, Ki67, and toll-like receptor 5 (TLR5) in prediction of malignant progression of Barrett’s metaplasia and low-grade dysplasia. This was a retrospective matched case–control study based on Northern and Central Finland population. Patients diagnosed with esophageal high-grade dysplasia or adenocarcinoma were included. From these patients, all previous endoscopy samples were obtained along with original diagnostic HE-slides and clinical data. Age- and sex-matched patients with non-progressing Ba…
Plausible Role of Estrogens in Pathogenesis, Progression and Therapy of Lung Cancer
2021
Malignant neoplasms are among the most common diseases and are responsible for the majority of deaths in the developed world. In contrast to men, available data show a clear upward trend in the incidence of lung cancer in women, making it almost as prevalent as breast cancer. Women might be more susceptible to the carcinogenic effect of tobacco smoke than men. Furthermore, available data indicate a much more frequent mutation of the tumor suppressor gene-p53 in non-small cell lung cancer (NSCLC) female patients compared to males. Another important factor, however, might lie in the female sex hormones, whose mitogenic or carcinogenic effect is well known. Epidemiologic data show a correlatio…
Desemmascarar el càncer: Centenars de malalties, un sol nom
2013
Tothom té una idea més o menys clara del que representa un càncer: un conjunt de cèl·lules que es divideixen sense control. Darrera aquesta imatge simplista s’amaga un dels problemes de salut més complexes i més greus que existeixen. És gràcies als avenços biomèdics dels últims vint anys que finalment estem reconeixent les grans diferències que hi ha entre els tipus de càncers coneguts, un descobriment que resultarà clau per a dissenyar teràpies més efectives en un futur proper.
Tumor odontogenico adenomatoide folicular: estudio inmunohistoquimico
2006
El tumor odontogénico adenomatoide (TOA) es una infrecuente lesión odontogénica benigna, que aparece en pacientes jóvenes, generalmente mujeres en la segunda década de la vida, a menudo como una lesión radiolúcida de aspecto quístico unilocular, en asociación a un diente, usualmente canino, no erupcionado. A pesar de haberse denominado también adenoameloblastoma o tumor ameloblástico adenomatoide, el TOA es una lesión benigna con una muy baja tendencia a la recidiva, mostrando una morfología muy peculiar (apariencia basaloide con estructuras glanduliformes, calcificaciones esferulares, presencia de material amiloide) que facilitan su reconocimiento histológico. Se presenta un análisis clíni…
Tumor odontogenico adenomatoide folicular: Estudio inmunohistoquimico
2006
El tumor odontogénico adenomatoide (TOA) es una infrecuente lesión odontogénica benigna, que aparece en pacientes jóvenes, generalmente mujeres en la segunda década de la vida, a menudo como una lesión radiolúcida de aspecto quístico unilocular, en asociación a un diente, usualmente canino, no erupcionado. A pesar de haberse denominado también adenoameloblastoma o tumor ameloblástico adenomatoide, el TOA es una lesión benigna con una muy baja tendencia a la recidiva, mostrando una morfología muy peculiar (apariencia basaloide con estructuras glanduliformes, calcificaciones esferulares, presencia de material amiloide) que facilitan su reconocimiento histológico. Se presenta un análisis clíni…
Pacientu drošība intravenozās medikamentozās aprūpes laikā intensīvās terapijas nodaļā
2019
Pacientu drošība ir daudzpusīgs jēdziens, kas vairāk un vairāk izplātās mūsdienu medicīnas nozarē Latvijā. Pacientu drošības jautājumā arī ir aktuāla sfēra medikamentozā drošība. Intensīvās terapijas nodaļas pacienti nepārtraukti saņem medikamentozo aprūpi un tāpēc atrodas riska grupā. Darbā tiek apskatīti pacientu drošības intravenozās medikamentozās aprūpes noteikumi un māsu darbības pacientu aprūpē. Bakalaura darba tēma – “Pacientu drošība intravenozās medikamentozās aprūpes laikā intensīvās terapijas nodaļā”. Tēmas aktualitāti nosaka pacientu nepārtraukta medikamentozā aprūpe, māsu darbu ietekmējošie faktori un kādas darbības veic māsas, lai nodrošinātu pacientu drošību. darbību noteikš…
Cross‐sectional associations between physical fitness and biomarkers of inflammation in children : the PANIC study
2023
Background Systemic low-grade inflammation has been proposed as an underlying pathophysiological mechanism for cardiometabolic diseases. We investigated the associations of physical fitness with systemic low-grade inflammatory state in a population sample of children. Methods Altogether 391 children aged 6–9 years were examined. Cardiorespiratory fitness (maximal power output, Wmax) was assessed by a maximal cycle ergometer test and neuromuscular fitness by hand grip strength, sit-up, standing long jump, 50-metre shuttle run, static balance, sit-and-reach, and box and block tests. Body fat percentage (BF%) and lean mass (LM) were assessed by dual-energy X-ray absorptiometry. High sensitivit…
Imputazione di pagamento - Datio in solutum - Quietanza
2017
Il lavoro offre una disamina aggiornata delle principali questioni teoriche e pratiche intorno agli istituti della imputazione del pagamento, della quietanza e della liberazione dalle garanzie. Ideale filo conduttore dell'analisi è costituito dagli adattamenti di questi istituti all'evolversi dei rapporti obbligatori nel segno della sempre più marcata dematerializzazione dei pagamenti