Search results for "ADE"
showing 10 items of 15269 documents
A numerical model for pre-monitoring design of historical colonnade courtyards: The case study of chiaramonte palace in palermo
2016
This paper proposes a numerical model that can be used for theoretical and experimental dynamic characterization of historical colonnade courtyards. Such an architectural element appears often in buildings of historical heritage and, especially under seismic excitation, it represents the most vulnerable structural part. Therefore, it is very important to have reliable as well as simple models available for vulnerability analysis, to evaluate different reinforcing systems if needed, or to plan dynamic characterization tests or monitoring campaigns, as in the present case. Chiaramonte Palace, a wonderful example of the historical heritage of Palermo, is investigated as case study. Firstly, a …
Incorporaciones de obras de arte a las colecciones de la Real Academia de Bellas Artes de San Carlos, 2015-2016
2016
Afinidades entre la arquitectura y la música. Algunas reflexiones
2019
VV. AA. (Obra coordinada por Tito Llopis / VTiM) L' escultor Josep Ginés i Marín (1768-1823). A propòsit de "La matança dels innocents" : Catálogo de…
2020
Procedure for a Temperature-Traffic Model on Rubberized Asphalt Layers for Roads and Railways
2017
The impact of temperature on the mechanical properties and thermal susceptibility of the railway bituminous sub-ballast layer, has served as motivation to develop the advanced measurement of thermal cycles in this layer and, an evaluation of the average seasonal temperatures interpolated by sinusoidal functions, of which characteristic parameters are determined. According to weather situation, Barber’s temperature model was used to prove the effectiveness for the railway superstructure. It is included the assessment of improved modified asphalt mixes performed with coarse rubber from scrap tires, having 1.5 to 3 percent of crumb rubber (particle size 0.2-4 mm) by weight of the total mix, as…
From Neo-Functional Peace to a Logic of Spillover in EU External Policy: A Response to Visoka and Doyle
2017
In their recently published JCMS article, Gezim Visoka and John Doyle have proposed the concept of ‘neofunctional peace’ as a means to conceptualize the EU's peacemaking practices in the case of the EU-facilitated Belgrade-Pristina dialogue. This article challenges the ‘neo-functional peace’ on conceptual and empirical grounds. We critically discuss Visoka and Doyle's (2016) reading of neofunctionalism and question parts of their empirical evidence given for the existence of a ‘neo-functional peace’. Going beyond a mere critique of the article by Visoka and Doyle and arguing that the authors may not have fully exploited neofunctionalism's potential for theorizing EU external policy, we stip…
Modelling load-transmission mechanisms in axially loaded RC columns retrofitted with steel jackets
2018
The use of steel jacketing technique is a common practice for retrofitting existing reinforced concrete (RC) columns, as it allows increasing load-carrying capacity and ductility of the member. When the external jacket has no-end connections – i.e. the jacket is indirectly loaded- the load sustained by the column is transferred from the inner RC core to the external jacket through shear stresses along the contact surface. The assessment of this mechanism is quite complex, due to the marked non-linear behaviour of constituent materials and to the calibration of a proper shear stress-relative slip constitutive law of the concrete-to-steel interface. In this paper, a step-by-step analytical ap…
Endometrial Receptivity Analysis (ERA): data versus opinions
2021
Abstract This article summarises and contextualises the accumulated basic and clinical data on the ERA test and addresses specific comments and opinions presented by the opponent as part of an invited debate. Progress in medicine depends on new technologies and concepts that translate to practice to solve long-standing problems. In a key example, combining RNA sequencing data (transcriptomics) with artificial intelligence (AI) led to a clinical revolution in personalising disease diagnosis and fostered the concept of precision medicine. The reproductive field is no exception. Translation of endometrial transcriptomics to the clinic yielded an objective definition of the limited time period …
The protein and microRNA cargo of extracellular vesicles from parasitic helminths – current status and research priorities
2020
Helminth parasites have a remarkable ability to persist within their mammalian hosts, which is largely due to their secretion of molecules with immunomodulatory properties. Although the soluble components of helminth secretions have been extensively studied, the discovery that helminths release extracellular vesicles (EVs) has added further complexity to the host-parasite interaction. Whilst several studies have begun to characterise the molecules carried by helminth EVs, work aimed at investigating their biological functions has been hindered by a lack of helminth-specific EV markers. To begin to address this, we summarised helminth EV literature to date. With a focus on the protein and mi…
Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment
2018
Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this approach might still remaininefficient and may cause many side effects, including severe complications and even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared with conventional therapies, allowing the possibility for improved effect in cancer therapy. Chemotherapeutics combined with oncolytic viruses exhibit stronger cytotoxic responses and oncolysis. Here, we have investigated the systemic delivery of the oncolytic adenovirus and paclitaxel encapsulated in extracellular vesicles (EV) formulation that, in vitro, s…