Search results for "ADN"
showing 10 items of 323 documents
Intracellular accumulation of incompletely processed transforming growth factor-alpha polypeptides in ground glass hepatocytes of chronic hepatitis B…
1996
Abstract Background: Transforming growth factor-alpha is an intracellularly processed and secreted polypeptide that induces a proliferative response in epithelial target cells and represents a potential regulatory factor in embryonic development, liver regeneration, and also hepatocarcinogenesis. We have observed focal transforming growth factor-alpha expression in liver tissues with chronic hepatitis B virus infection. Methods: To further elucidate the nature of this focal transforming growth factor-alpha accumulation were have analyzed overall 23 different liver tissues with chronic hepatitis B virus and hepatitis C virus infection as well as normal liver tissues by immunohistology, ELISA…
Pašregulācijas stilu, tagadnes laika perspektīvu un darba intensitātes savstarpēja saistība
2017
Pētījuma “Pašregulācijas stilu, tagadnes laika perspektīvu un darba intensitātes savstarpēja saistība” mērķis bija noskaidrot kādas tagadnes laika perspektīvas un pašregulācijas stili prognozē darba intensitāti, un, vai pastāv saistība starp tagadnes laika perspektīvu, pašregulācijas stiliem un darba intensitāti. Dati tika ievākti no 148 strādājošiem cilvēkiem, kuri dzīvo dažādās Latvijas pilsētās, vecumā no 25 līdz 65 gadiem (vidējais vecums M = 38,03 gadi SD = 12,46), no kuriem 76 (51,35%) bija sievietes un 72 vīrieši (48,65%). Datu ievākšanai tika izmantotas šādas metodes: Pašregulācijas stilu aptauja, Tagadnes laika perspektīvas aptauja (TLPA) un Darba intensitātes aptauja. Visas metode…
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
2020
Telomeres have the ability to adopt a lariat conformation and hence, engage in long and short distance intra-chromosome interactions. Budding yeast telomeres were proposed to fold back into subtelomeric regions, but a robust assay to quantitatively characterize this structure has been lacking. Therefore, it is not well understood how the interactions between telomeres and non-telomeric regions are established and regulated. We employ a telomere chromosome conformation capture (Telo-3C) approach to directly analyze telomere folding and its maintenance in S. cerevisiae. We identify the histone modifiers Sir2, Sin3 and Set2 as critical regulators for telomere folding, which suggests that a dis…
Madness and Bestialization in Euripides’ Heracles. Οὔποτ' ἄκραντα δόμοισι Λύσσα βακχεύσει.
2013
Against a background of anxious evocation of Dionysiac rites, Euripides’ Heracles stages the extreme degradation of the tragic hero, who as a consequence of the hatred of a divinity loses his heroic traits and above all his human ones in the exercise of brutal violence. By means of comparing Heracles to a furious bull assailing its prey, the tragedian clearly shows the inexorability of the divine will and its arbitrariness, and emphasizes madness itself through images traditionally associated with the bull. However, the reference to monstrosity and animals does not involve only Heracles, but also concerns the representation of Lyssa, the demon of madness sent by Hera to induce Heracles to s…
Genomics of mRNA turnover
2007
Most studies on eukaryotic gene regulation have focused on mature mRNA levels. Nevertheless, the steady-state mRNA level is the result of two opposing biological processes: transcription and degradation, both of which can be important points to regulate gene expression. It is now possible to determine the transcription and degradation rates (TR and DR), as well as the mRNA amount, for each gene using DNA chip technologies. In this way, each individual contribution to gene expression can be analysed. This review will deal with the techniques used for the genomic evaluation of TR and DR developed for the yeast Saccharomyces cerevisiae. They will be described in detail and their potential draw…
A method for genome-wide analysis of DNA helical tension by means of psoralen-DNA photobinding
2010
The helical tension of chromosomal DNA is one of the epigenetic landmarks most difficult to examine experimentally. The occurrence of DNA crosslinks mediated by psoralen photobinding (PB) stands as the only suitable probe for assessing this problem. PB is affected by chromatin structure when is done to saturation; but it is mainly determined by DNA helical tension when it is done to very low hit conditions. Hence, we developed a method for genome-wide analysis of DNA helical tension based on PB. We adjusted in vitro PB conditions that discern DNA helical tension and applied them to Saccharomyces cerevisiae cells. We selected the in vivo cross-linked DNA sequences and identified them on DNA …
Las competencias básicas en ciencias sociales: trabajo y formación. ¿Un reto para el docente?
2013
En los últimos años una nueva jerga se ha instalado en la didáctica de las Ciencias Sociales. Las Competencias Básicas son presentadas como una innovación educativa donde encontrar soluciones contra el fracaso escolar y aumentar la significancia de los aprendizajes, a la par que la motivación del alumnado. Este estudio analiza cómo trabajan los docentes de Ciencias Sociales de 4º de ESO las Competencias Social-Ciudadana y la Competencia en Comunicación Lingüística. Indagamos por tanto, en la formación del profesorado en Competencias Básicas, sus conocimientos del currículo y las metodologías de aula, a través de un análisis de los contenidos del currículo en relación a estas dos competencia…
Molecular basis of the primary and secondary radiation damage to DNA/RNA nucleobases
2017
La interacción radiación-materia ha sido una de las grandes preocupaciones científicas de los últimos tiempos, y es que es clave para entender la vida en la Tierra tal y como la conocemos. En este contexto, son de especial relevancia los procesos inducidos en sistemas celulares por radicación externa, en particular, aquellos localizados en los ácidos nucleicos, ya que éstos son los portadores de la información genética de todos los seres vivos. Sólo la comprensión de la competitividad entre procesos inocuos y lesivos inducidos por radiación llevará al entendimiento del sutil equilibrio entre integridad y cambio, salud y enfermedad, y en términos más globales, inmovilidad y evolución. La Tes…
Paralēla radniecīgu svešvalodu apguve
2020
Bakalaura darba ” Paralēla radniecīgu svešvalodu apguve” mērķis bija izpētīt radniecīgo valodu kā svešvalodu, izmantojot piemērus no somu un igauņu valodas. Darba izstrādes gaitā autore atrisināja sekojošus uzdevumus. Proi, pirmajā nodaļā tika aplūkota radnieciskās valoda pēc teorētiskos aspektiem. Otrajā nodaļā tika izpētīta valodas apgūšanas stretēģijas klasifikācija. Bet trešajā nodaļā, pamatojoties uz veiktajiem novērojumiem un somu un igauņu valodas salīdzinājumiem, tika izpētītas un analizētas somu un igauņu valodas kā radniecīgas valodas. Darba nobeigumā tika secināts, ka valodas attīstībā radniecīgu valodu ietekmei ir diezgan liela loma. Jau pēc pašiem neatkarības atgūšanas gadiem i…
Overcoming resistance to product rebranding
2015
Purpose – The purpose of this article is to understand how and why consumers resist or accept product rebranding. It seeks to identify and to quantify the drivers of attitudes toward this marketing practice to guide marketing managers in the execution of an effective changeover. Design/methodology/approach – The research is conducted in three stages. First, a qualitative study is run among 45 consumers to identify variables that might influence attitudes toward product rebranding. Second, a review of literature on the emotion of surprise is carried out to specify the relationships between the variables previously identified and to formulate hypotheses. Third, a quantitative study is conduc…