Search results for "ADN"
showing 10 items of 323 documents
Valor pronóstico del gen de fusión TMPRSS2-ERG, metilación de PITX2 y marcadores inmunohistoquímicos en el cáncer de próstata.
2015
El cáncer de próstata es una de las causas de morbimortalidad más importantes en los países desarrollados. Actualmente las herramientas tanto diagnósticas como pronósticas con las que contamos son limitadas. A pesar de que el PSA ha supuesto un avance importante en el diagnóstico y pronóstico del cáncer de próstata no es un buen marcador cáncer-específico. Además, en las últimas décadas, el uso indiscriminado del PSA para la búsqueda del cáncer de próstata ha llevado a un sobrediagnóstico y sobretratamiento de esta patología. En cuanto a la biopsia, es una técnica invasiva no exenta de morbilidad. Es por ello que aparece la necesidad de identificar nuevas herramientas que puedan ayudarnos a…
The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
2021
AbstractTo investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolim…
Towards understanding the abundance of non-pollen palynomorphs : A comparison of fossil algae, algal pigments and sedaDNA from temperate lake sedimen…
2018
Given the increased interest in non-pollen palynomorphs (microscopic objects other than pollen identified from pollen slides) in palaeoecological studies, it is necessary to seek a deeper understanding of the reliability of these results. We combined quantitative information of algal pigments and sedimentary ancient DNA (sedaDNA) of phylotaxonomical resolution to validate the richness and abundance of fossil algae in the sediment of a small temperate lake. For the first time, fossil and sedaDNA algae data were combined in a composite data-set and used to reconstruct algae turnover rates over the last 14,500 years. This comparison serves as both an example of howfossil algae can be used to a…
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
2019
Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…
Modulāra sistēmas dizaina ieviešana "white-label" mobilo lietotņu izstrādei
2022
“White-label” mobilo lietotņu izstrāde ir izstrādes stratēģija, kas sevī ietver bāzes koda izstrādi un bāzes pielāgošanu, izveidojot dažādas programmas dažādu klientu prasībām. Šādai stratēģijai palīdz pielāgojama sistēmas struktūra un modulāra dizaina ieviešana padara sistēmu pielāgojamāku. Darbā tiks apskatīti ieteikumi modulāra dizaina ieviešanai un analizēti attiecībā pret “white-label” lietotņu izstrādes pieredzi.
Dabisko zālāju indikatorsugu izplatība Bērzciema apkārtnē atkarībā no biotopu daudzveidības
2015
Dabiskie zālāji ir apdraudēti, to veicina cilvēku došanās prom no laukiem un zālāju neapsaimniekošana. Pētījuma mērķis bija noskaidrot dabisko zālāju indikatorsugu sastopamību atkarībā no biotopu daudzveidības un sastāva Bērzciema apkārtnē. Indikatorsugas un biotopi kartēti 0.5x0.5 m kvadrātos, indikatorsugu sastopamība atkarībā no biotopu daudzveidības analizēta ar klasteranalīzi un korelācijas analīzi. Indikatorsugu skaits variēja no 0 līdz 15. Lielākoties tās bija pilnas gaismas augi, kas pielāgoušies nabadzīgām sausām un slapjām augsnēm. Nav novērojama tendence, ka liels biotopu daudzums nodrošina attiecīgi lielu indikatorsugu skaitu. Darba apjoms ir 43 lapas. Darbs sastāv no 6 nodaļām …
A Data-Driven Approach to Dynamically Learn Focused Lexicons for Recognizing Emotions in Social Network Streams
2016
Opinion Mining aims at identifying and classifying subjective information in a collection of documents. A variety of approach exists in literature, ranging from Supervised Learning to Unsupervised Learning. Currently, one of the biggest opinion resource of opinionated texts existing on the Web is represented by Social Networks. Networks are not only a vast collection of documents but they also represent a dynamic evolving resource as the users keep posting their own opinions. We based our work relying on this idea of dynamicity, building an evolving model that updates itself in real time as users submit their posts. This is done through a set of supervised techniques based on a Lexi- con of…
Exploring relationships between audio features and emotion in music
2009
In this paper, we present an analysis of the associations between emotion categories and audio features automatically extracted from raw audio data. This work is based on 110 excerpts from film soundtracks evaluated by 116 listeners. This data is annotated with 5 basic emotions (fear, anger, happiness, sadness, tenderness) on a 7 points scale. Exploiting state-of-the-art Music Information Retrieval (MIR) techniques, we extract audio features of different kind: timbral, rhythmic and tonal. Among others we also compute estimations of dissonance, mode, onset rate and loudness. We study statistical relations between audio descriptors and emotion categories confirming results from psychological …
First impression misleads emotion recognition
2019
Recognition of others' emotions is a key life ability that guides one's own choices and behavior, and it hinges on the recognition of others' facial cues. Independent studies indicate that facial appearance-based evaluations affect social behavior, but little is known about how facial appearance-based trustworthiness evaluations influence the recognition of specific emotions. We tested the hypothesis that first impressions based on facial appearance affect the recognition of basic emotions. A total of 150 participants completed a dynamic emotion recognition task. In a within-subjects design, the participants viewed videos of individuals with trustworthy-looking, neutral, or untrustworthy-lo…
Recommendations for a nomenclature system for reporting methylation aberrations in imprinted domains
2018
The analysis of DNA methylation has become routine in the pipeline for diagnosis of imprinting disorders, with many publications reporting aberrant methylation associated with imprinted differentially methylated regions (DMRs). However, comparisons between these studies are routinely hampered by the lack of consistency in reporting sites of methylation evaluated. To avoid confusion surrounding nomenclature, special care is needed to communicate results accurately, especially between scientists and other health care professionals. Within the European Network for Human Congenital Imprinting Disorders we have discussed these issues and designed a nomenclature for naming imprinted DMRs as well …