Search results for "ADP-Ribosylation"

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The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic

2022

ELMODs are a family of three mammalian paralogs that display GTPase activating protein (GAP) activity towards a uniquely broad array of ADP-ribosylation factor (ARF) family GTPases that includes ARF-like (ARL) proteins. ELMODs are ubiquitously expressed in mammalian tissues, highly conserved across eukaryotes, and ancient in origin, being present in the last eukaryotic common ancestor. We described functions of ELMOD2 in immortalized mouse embryonic fibroblasts (MEFs) in the regulation of cell division, microtubules, ciliogenesis, and mitochondrial fusion. Here, using similar strategies with the paralogs ELMOD1 and ELMOD3, we identify novel functions and locations of these cell regulators a…

Cell divisionGTPase-activating proteinGolgi ApparatusGTPaseBiologyMicrotubulesMitochondrial Dynamicssymbols.namesakeMiceMicrotubuleCiliogenesisAnimalsCiliaMolecular BiologyADP-Ribosylation FactorsCiliumGTPase-Activating ProteinsCorrectionCell BiologyGolgi apparatusFibroblastsCell biologyCytoskeletal Proteinsmitochondrial fusionsymbolsSignal Transduction

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