Search results for "ADS"
showing 10 items of 1953 documents
Protein denaturation caused by heat inactivation detrimentally affects biomolecular corona formation and cellular uptake
2018
Adsorption of blood proteins to the surface of nanocarriers is known to be the critical factor influencing cellular interactions and eventually determining the successful application of nanocarriers as drug carriers in vivo. There is an increasing number of reports summarizing large data sets of all identified corona proteins. However, to date our knowledge about the multiple mechanisms mediating interactions between proteins and nanocarriers is still limited. In this study, we investigate the influence of protein structure on the adsorption process and focus on the effect of heat inactivation of serum and plasma, which is a common cell culture procedure used to inactivate the complement sy…
Silica-gelatin hybrid sol-gel coatings: A proteomic study with biocompatibility implications.
2018
Osseointegration, including the foreign body reaction to biomaterials, is an immune‐modulated, multifactorial, and complex healing process in which various cells and mediators are involved. The buildup of the osseointegration process is immunological and inflammation‐driven, often triggered by the adsorption of proteins on the surfaces of the biomaterials and complement activation. New strategies for improving osseointegration use coatings as vehicles for osteogenic biomolecules delivery from implants. Natural polymers, such as gelatin, can mimic Collagen I and enhance the biocompatibility of a material. In this experimental study, two different base sol–gel formulations and their combinati…
2020
Worldwide, tons of lignin is produced annually in pulping plants and it is mainly considered as a waste material. Usually lignin is burned to produce energy for the pulping reactors. The production of value-added materials from renewable materials like lignin, has proved to be challenging. In this study, the effects of addition of three different types of lignin in the production of tannin/furanic foams is investigated. The foams were matured, first at 373 K and finally carbonized at 1073 K and the properties of them including mechanical strength, specific surface area and pore development are investigated before and after thermal treatment. According to the results, higher mechanical stren…
Immunoadsorption for treatment of severe atopic dermatitis.
2017
Atopic dermatitis (AD) is a common disease affecting up to 10-20% of the population with the largest disease burden in childhood. Treatment options include basic emollient treatment, topical as well as systemic immunosuppressants. The pathogenesis is complex and among various triggers, genetic predisposition and immunological alterations contribute to development of disease. Atopy is common in patients with AD and many patients have high levels of Immunoglobulin E (IgE), some of which recognizes exogenous or auto/self-allergens. Treatment options targeting IgE such as specific immunotherapy against e.g. house dust mites or using anti-IgE antibodies (omalizumab) showed variable results that …
Odorant Metabolism Analysis by an Automated Ex Vivo Headspace Gas-Chromatography Method
2015
International audience; In the olfactory epithelium (OE), odorant metabolizing enzymes have the dual function of volatile component detoxification and active clearance of odorants from the perireceptor environment to respectively maintain the integrity of the tissues and the sensitivity of the detection. Although emphasized by recent studies, this enzymatic mechanism is poorly documented in mammals. Thus, olfactory metabolism has been characterized mainly in vitro and for a limited number of odorants. The automated ex vivo headspace gas-chromatography method that was developed here was validated to account for odorant olfactory metabolism. This method easily permits the measurement of the f…
Surface-modified 3D starch-based scaffold for improved endothelialization for bone tissue engineering
2009
Providing adequate vascularization is one of the main hurdles to the widespread clinical application of bone tissue engineering approaches. Due to their unique role in blood vessel formation, endothelial cells (EC) play a key role in the establishment of successful vascularization strategies. However, currently available polymeric materials do not generally support EC growth without coating with adhesive proteins. In this work we present argon plasma treatment as a suitable method to render the surface of a 3D starch-based scaffold compatible for ECs, this way obviating the need for protein pre-coating. To this end we studied the effect of plasma modification on surface properties, protein …
Standardized on-road tests assessing fitness-to-drive in people with cognitive impairments: A systematic review.
2020
Objective The on-road assessment is the gold standard because of its ecological validity. Yet existing instruments are heterogeneous and little is known about their psychometric properties. This study identified existing on-road assessment instruments and extracted data on psychometric properties and usability in clinical settings. Method A systematic review identified studies evaluating standardized on-road evaluation instruments adapted for people with cognitive impairment. Published articles were searched on PubMed, CINHAL, PsycINFO, Web of Science, and ScienceDirect. Study quality and the level of evidence were assessed using the COSMIN checklist. The collected data were synthetized usi…
The role of emotion dysregulation in adolescents’ problematic smartphone use: A study on adolescent/parents triads
2021
Abstract The pervasive use of mobile phones among adolescents has led researchers to evaluate the role of parental characteristics in connection with their children's problematic smartphone use (PSU). The present study involved mother/father/adolescent triads and aimed to test a model examining the role of both parents' and adolescents' emotion dysregulation (ED) in predicting children's PSU. Two hundred and fifty-two adolescent (57.5% females; M age = 13.54, SD = 0.73)/mother (M age = 43.92, SD = 4.46)/father (M age = 47.60, SD = 5.10) triads provided measures of PSU and ED. Results from path model showed that, after controlling for adolescents' age and gender as well as for parents' age a…
Korpusonomastinen tutkimus slanginimistä Hesa ja Stadi digitaalisissa diskursseissa
2019
Artikkelissamme selvitämme Helsinkiä tarkoittavien slanginimien, Hesan ja Stadin, käyttöä uudentyyppisen aineiston ja menetelmän avulla. Aiemmissa näitä nimiä koskevissa tutkimuksissa lähtökohta on ollut kvalitatiivinen, mutta tässä tutkimuksessa lähdemme liikkeelle laajasta digitaalisesta aineistosta ja tilastollisista menetelmistä. Tutkimuksemme on uusi avaus nimistöntutkimuksessa, ja nimitämme sitä korpusavusteiseksi nimistöntutkimukseksi, lyhyemmin korpusonomastiikaksi.
 Aineistonamme on laaja Suomi24-keskustelufoorumista muodostettu ja Kielipankista saatava Suomi24-korpus, josta olemme hakeneet Hesa- ja Stadi-nimet. Tutkimus toteutetaan korpusavusteisena diskurssintutkimuksena. Mo…
Gadskārtu svētki - 1,5 – 3 gadu vecu bērnu sociālo prasmju veicinātāji pirmsskolas izglītības iestādē
2021
Kvalifikācijas darbā ,, Gadskārtu svētki - 1,5 – 3 gadu vecu bērnu sociālo prasmju veicinātāji pirmsskolas izglītības iestādē” tiek pētīta sociālo prasmju veicināšana gadskārtu svētkos 1,5 – 3 gadus veciem bērniem. Darba autore veic teorētisku literatūras analīzi par sociālo prasmju veicināšanu, 1,5 -3 gadus vecu bērnu attīstības raksturojumu, pēta sociālo prasmju veicināšanu gadskārtu svētkos pirmsskolā, veic empīrisko pētījumu, izmantojot pedagoģisko novērojumu un izmēģinājumdarbību. Kvalifikācijas darba pirmajā daļā tiek analizēta literatūra otrajā daļā tiek veikts empīriskais pētījums, kurš balstās uz praktisku izmēģinājumdarbību . Lai atbildētu uz pētāmo jautājumu ,,Kā veicināt sociālā…