Search results for "ADT"
showing 10 items of 92 documents
School principals’ point of view on pupils’ participation
2021
La participación es un derecho que los niños y niñas deben tener la oportunidad de ejercer y la escuela es un escenario idóneo para que el alumnado pueda hacer oír su voz exponiendo ideas, tomando decisiones y formulando propuestas. Con el objetivo de detectar las opciones del alumnado de participar en el centro y apuntar vías para maximizarlas efectuamos un estudio a partir de un cuestionario elaborado ad hoc dirigido a todos y todas los directores y directoras de escuelas de Cataluña. En concreto, participaron 684 y los resultados indican que los niños y las niñas no solo opinan en clase, sino que toman decisiones cuando trabajan en grupo, en relación con la convivencia o votando sus prop…
Uno studio comparativo in silico sui possibili target di Ataluren e analoghi farmaci promotori di readthrough di codoni di stop prematuri
2019
E’ noto in letteratura che Ataluren (acido 5-(fluorofenil)-1,2,4-ossadiazolil-benzoico) sia in grado di sopprimere le mutazioni non senso favorendo il readthrough dei codoni di stop prematuri, anche se il suo meccanismo di azione non risulta ancora chiaro. La probabile interazione tra Ataluren e CTFR-mRNA è stata precedentemente studiata mediante dinamica molecolare. In questo studio1, abbiamo esteso il modeling del probabile meccanismo di azione di Ataluren mediante approcci computazionali completementari, quali Induced Fit Docking (IFD), Quantum Polarized Ligand Docking (QPLD), metodi MM-GBSA e mutagenesi computazionale. Oltre a considerare il CTFR-mRNA, sono stati presi in considerazione…
Proposal of a Modelling of the Innovation Process in an International Manufacturing Company
2017
Nowadays, to cope with the competition, and to ensure the durability of their activities, companies have to be able to innovate. Manufacturing companies operating in a B2B market often perceive innovation as a technological result. However, innovation is often more characterized as a process. The needs of the users, and not only the technology, can achieve innovation. In this context, our paper intends to determine how to involve better the users in the innovation process of an international manufacturing company, which is, according to us, representative of the current manufacturing companies. The aim of our research paper is to help manufacturing companies to manage innovation led by user…
Antecedents and Outcomes of Absorptive Capacity : Three Studies in the Spanish Manufacturing Sector
2013
En los últimos años, las investigaciones en dirección estratégica han señalado al conocimiento como uno de los recursos claves que permiten la generación de ventajas competitivas. No obstante, para la creación y mantenimiento de dichas ventajas es necesario el desarrollo de capacidades que permitan la transferencia y uso eficiente de dicho conocimiento, incluso en condiciones marcadas por la agitación y el dinamismo del entorno. En este marco, la capacidad de absorción ha sido destacada como una de las capacidades esenciales que proporciona a las organizaciones la habilidad de asimilar, transformar y explotar con éxito el conocimiento externo. No obstante, a pesar de las constantes contribu…
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models
Le pont des Grilles de la Basse-Seille (fin XIVe siècle), ancienne porte d’eau de l’enceinte urbaine de Metz
2017
The bridge des Grilles de la Basse-Seille is one of the last vestiges of the medieval fortification in Metz. It is one of rare examples of fortified bridge in France. Built in the end of the 14th century, it is backfilled in 1911 and only its upper section is visible. An archaeological and historic study was made in 2011 to understand the configuration and the functioning of the bridge in the Middle Ages.
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells
2016
Siracusa e la Sicilia nel III secolo a.C.: problemi conoscitivi e proposte di lettura dei fenomeni urbanistici e architettonici
2017
L’evoluzione sotto il profilo urbanistico e architettonico delle città di Sicilia nel III secolo a.C. può essere compresa solo a partire da un esame delle evidenze di Siracusa, la maggiore città dell’Occidente greco-ellenistico e capitale di un regno che sotto Agatocle e soprattutto sotto Ierone II vede un prodigioso sviluppo non solo per l’estensione dell’area urbana, ma soprattutto per la riconfigurazione dello spazio cittadino in forme innovative, destinate a influenzare in maniera decisiva anche le città minori del regno e dell’Oriente dell’isola, e successivamente anche dei comprensori centro-occidentali e settentrionali. L’aspetto più importante e programmatico nella rimodulazione del…
RESCUE OF LRBA GENE EXPRESSION IN PRIMARY HUMAN FIBROBLASTS CHARACTERISED BY NONSENSE MUTATION c. 5047 (C>T).
2021
Primary immunodeficiencies (PIDs) are rare genetic diseases characterized by susceptibility to infections, increased risk of autoimmunity, hypogammaglobulinemia, and lymphoproliferative syndromes. PIDs are associated to genetic alterations in about 400 known genes, among which, mutations of the LRBA gene. LRBA gene encodes a widely expressed multi-domain protein with highly conserved BEACH domain, involved in regulation of endosomal trafficking, particularly endocytosis of ligand-activated receptors. It was reported that stop mutations affect this gene leading to the loss of the protein expression. Recently, we identified three Translational Readthrough Inducing Drug (TRID), that showed hig…
PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.
2011
We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…