Search results for "ADULT"

Handicap et qualité de vie

2010

Oxidative stress and antioxidant levels in patients with anorexia nervosa: A systematic review and exploratory meta-analysis.

2015

Objective To systematically review and meta-analyze oxidative stress and antioxidant markers in anorexia nervosa (AN). Methods Electronic PubMed search from database inception until 12/31/2013. Out of 1062 hits, 29 studies comparing oxidative stress/antioxidant markers between patients with AN and healthy controls (HCs) with a total of 1,729 participants (AN-=-895, HCs-=-834) were eligible. Data about oxidative stress and antioxidant markers, independent of their source, were extracted. We calculated random effects standardized mean differences (SMDs) as effect size measures for outcomes reported in ≥5 studies; others were summarized descriptively. Results Compared to HCs, AN patients showe…

Expression of p63, p53 and ki-67 in patients with cervical intraepithelial neoplasia

2017

Objective: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical intraepithelial neoplasia and in a control group. Material and Method: 58 patients were enrolled in the study. Each patient underwent a colposcopy-guided biopsy of the cervix. Immunostaining for markers (p53, p63 and Ki-67) was performed on tissue samples of normal cases (n=10), CIN I (n=20), CIN II (n=14), and CIN III (n=14). Results: Our study showed a significant increase of the expression of t…

Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations

1999

Two biallelic polymorphisms in introns 3 and 6 of the p53 gene were analysed for a possible risk-modifying effect for ovarian cancer. Germline DNA was genotyped from 310 German Caucasian ovarian cancer patients and 364 healthy controls. We also typed 124 affected and 276 unaffected female carriers with known deleterious BRCA1 or BRCA2 germline mutation from high-risk breast-ovarian cancer families. Genotyping was based on PCR and high-resolution gel electrophoresis. German ovarian cancer patients who carried the rare allele of the MspI restriction fragment length polymorphism (RELP) in intron 6 were found to have an overall 1.93-fold increased risk (95% confidence internal (CI) 1.27–2.91) w…

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

2018

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…

Parenthood and changes in physical activity from early adulthood to mid‐life among Finnish adults

2022

This study examined longitudinal associations between parenthood-related factors and physical activity from young adulthood to midlife over a 19-year follow-up period. Participants (n=761) at the ongoing Cardiovascular Risk in Young Finns Study responded to a self-report questionnaire in their adulthood (in 1992, 2001, 2007 and 2011). Participants were classified as meeting or not meeting an aerobic physical activity recommendation. Parenthood related factors included the age of having their first child, as well as the number and age of the children. Analyses of Generalized Estimation Equations were performed and adjusted for several demographic and health-related covariates. Both mothers a…

Sentirsi Genitori. Esperienze di maltrattamento nell'infanzia e pratiche di parenting in età adulta

Technikum dla przodujących robotników w polskim systemie szkolnictwa zawodowego (1971-1982)

2018

W okresie PRL-u z inicjatywy PZPR powstało w 1971 r. technikum dla przodujących robotników. Uchwała nr 124 Rady Ministrów z dnia 1 lipca 1971 r. dała robotnikom możliwość zdobycia kwalifikacji zawodowych i uzyskania świadectwa dojrzałości po dwuletnim okresie edukacji. Takich szkół powstało ponad 30 w skali całego kraju. Do placówek tych kierowano wyróżniających się aktywną postawą społeczno-zawodową robotników, absolwentów zasadniczych szkół zawodowych. Celem ich było przygotowanie dla gospodarki narodowej dobrych fachowców, ale również aktywnych działaczy partyjnych. Rozpoczęły one pracę dydaktyczną we wrześniu 1971 r. Stworzono w nich bardzo dobre warunki uczenia się dorosłym uczniom, za…

The lived experience of rescuing people who have driven into floodwater: Understanding challenges and identifying areas for providing support.

2018

Background: Drowning is a major public health issue, with risk increasing during times of flood. Driving into floodwater is a major risk factor for flood-related drowning and injury, and despite widespread public health campaigns, many people continue to undertake this risky behaviour and require rescue. Purpose: We aimed to identify key challenges faced by emergency services personnel when rescuing those who have driven into floodwater, and to identify strategies for supporting rescuers in this important role. Methods: Australian flood rescue operators (N = 8) who had previously rescued a driver who had driven into floodwater participated in semi-structured interviews. Data were analysed u…

Psychometric properties of the Assessment Tool for Perceived Agency (ATPA-22) - utility for the rehabilitation of young adults not in education, empl…

2020

Background: Promoting and supporting agency have been at the heart of the debate multidisciplinary. To promote self-awareness of young people’s agency and identify persons in need of support the Assessment Tool for Perceived Agency (ATPA-22) was developed. Aim: This study aims to evaluate the psychometric properties of the ATPA-22. Participants were young adults not in education, employment or training (NEETs) and students in higher education (HEI). Materials and methods: The main data analysis was implemented by Many Faceted Rasch (MFR) analysis. Results: The ATPA-22 items defined a unidimensional construct with reasonable internal consistency and separation ability. The ATPA-22 was capabl…