Search results for "AEDL"
showing 3 items of 3 documents
Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity
2016
Background & Aims Partially degraded gluten peptides from cereals trigger celiac disease (CD), an autoimmune enteropathy occurring in genetically susceptible persons. Susceptibility genes are necessary but not sufficient to induce CD, and additional environmental factors related to unfavorable alterations in the microbiota have been proposed. We investigated gluten metabolism by opportunistic pathogens and commensal duodenal bacteria and characterized the capacity of the produced peptides to activate gluten-specific T-cells from CD patients. Methods We colonized germ-free C57BL/6 mice with bacteria isolated from the small intestine of CD patients or healthy controls, selected for their in v…
2021
The microbiota impacts mesenteric ischemia-reperfusion injury, aggravating the interaction of leukocytes with endothelial cells in mesenteric venules. The role of defined gut microbiomes in this life-threatening pathology is unknown. To investigate how a defined model microbiome affects the adhesion of leukocytes in mesenteric ischemia-reperfusion, we took advantage of gnotobiotic isolator technology and transferred altered Schaedler flora (ASF) from C3H/HeNTac to germ-free C57BL/6J mice. We were able to detect all eight bacterial taxa of ASF in fecal samples of colonized C57BL/6J mice by PCR. Applying qRT-PCR for quantification of species-specific 16S rDNA sequences of ASF bacteria, we fou…
Agencias de empleo y desarrollo local: ¿una actividad del Tercer Sector?
2010
Ricardo.Calvo@uv.es En la actualidad, el desarrollo económico y social de un territorio necesita de los esfuerzos mancomunados de todos y cada uno de los agentes presentes en el medio. Es por ello que el presente artículo pretende reflexionar sobre la vinculación directa existente entre dos de ellos, por un lado las Agencias de Desarrollo Local –ADL’scomo máximo exponente del modelo de desarrollo local y por otro las organizaciones pertenecientes al Tercer Sector, como entidades clave en el sostenimiento y desarrollo social de la comunidad. Para ello partiendo de las características propias del modelo actual de desarrollo local implantado, propondremos dos decálogos de conclusiones, que ana…