Search results for "AEM"

Long-term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia

2023

Introduction: Lomitapide is a microsomal triglyceride transfer protein inhibitor for patients with homozygous familial hypercholesterolaemia. Due to its mechanism of action, potential hepatic effects of lomitapide are of clinical interest. This study aimed to determine the long-term hepatic safety of lomitapide. Methods: Data were aggregated from the pivotal phase 3 and extension phase clinical trial with lomitapide (median 5.1 years; serum total bilirubin, transaminases, cytokeratin-18 [CK-18] and enhanced liver fibrosis [ELF] score, fat-soluble vitamins and essential fatty acids), 8-year data from the Lomitapide Observational Worldwide Evaluation Registry (LOWER) and real-world evidence f…

Effects of amlodipine on renal haemodynamics in mild to moderate hypertensive patients. A randomized controlled study versus placebo. Eur J Clin Phar…

1993

In this study the efficacy and safety of short-term amlodipine administration on renal haemodynamics were evaluated in mild to moderate hypertensive subjects. Our final goal was to evaluate whether the reduced blood pressure induced by treatment was associated with maintenance of renal function. After a run-in period with placebo, 30 hypertensive patients without cardiac or renal diseases were randomly allocated to a double-blind 4 weeks controlled study with amlodipine 10 mg once a day (15 patients) or placebo (15 patients). Renal haemodynamic measurements included effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) by radionuclide study using 131I-hippuran and 99mTc, w…

Fatal Pulmonary Hemorrhage Through Fiberoptic Broncoscopy in a Well Controlled Diabetic Female With Mucormycosis

2008

A rare case of invasive pulmonary mucormycosis complicated by fatal massive haemoptysis through bronchoscopy in a patient with a well controlled diabetes is reported. Histological features of infection are reported and the characteristic aspects of the staining are discussed. Fiberoptic bronchoscopy revealed bilateral obstruction of the segmental bronchi and fatal massive bleeding occurring because of biopsy sampling. Caution is warranted in the use of bronchoscopy sampling in patients with radiological features of cavitated lesions of fungal origins. Better preventive and early therapeutic antifungal treatments are needed to avoid this serious complication.

Cavernous haemangioma of the external auditory canal: clinical case and review of the literature

2012

Although benign vascular lesions are frequent in the head and the neck region, clinical evidence of cavernous haemangioma of the external auditory canal is extremely rare; when present, the lesion invades the middle ear space. Herein, a rare case of a soft mass filling the external auditory canal, not involving the tympanic membrane, in a symptomatic 59-year-old male is described. Clinical and audiological characteristics, imaging studies and surgical treatment with histological evaluation are reported, which led to a diagnosis of a cavernous haemangioma. This is only the seventh case described in the literature, to date, not involving the tympanic membrane and the middle ear space. In addi…

Novel human pathological mutations. Gene symbol: F8. Disease: Haemophilia A

2010

The Small Angle Scattering technique: an effective tool in the structural investigation of archaeologically relevant specimens

2012

An overview of application of Small Angle X-ray Scattering (SAXS) techniques to topics of interest in the field of Cultural Heritage is presented. The basic concepts of the technique, a description of sources and laboratory instrumentation and some models and methods for data analysis are discussed. Applications of SAXS to various kinds of materials are reported to obtain information on the structure useful to shed light in some subjects such as preparation, physical treatment, traceability and degradation of materials.

The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19

2021

When the current SARS-CoV-2 pandemic began in early 2020, the global magnesium researcher community came together and noted the striking similarities between COVID-19 risk factors and conditions associated with magnesium deficit state in humans, reasoning that magnesium deficiency could worsen the course of COVID-19 [1-4]. This prompted establishment of a worldwide collaborative network with regular virtual meetings to brainstorm the associations between magnesium and COVID-19. We hypothesize that magnesium deficiency, a common but mostly unrecognized state in modern global societies, could be an important component of the susceptibility to SARS-CoV-2 infection. Consequently, restoring the …

Sorafenib as a feasible therapeutic option in haemophiliacs with hepatocellular carcinoma

2010

hepatocellular carcinoma, haemophilia, treatment

Concurrent staphylococcal and herpes simplex infections – diagnostic pitfalls. A case report

2018

We describe the case of a six-year-old boy with concurrent staphylococcal septicaemia, herpes simplex virus encephalitis (HSVE), and haemorrhagic erosive oesophagitis. Due to guiding clinical and lab symptoms that suggested a diagnosis of staphylococcal sepsis with central nervous system (CNS) involvement, acyclovir treatment was discontinued a"er three days, but the lack of progress in neurological status, further lab tests, and CT and MRI imaging led the authors to consider possible HSV infection, and this diagnosis was con#rmed by PCR test. Even though the treatment for HSV was applied again, the long gap in acyclovir medication contributed to a severe neurological de#cit and an adverse …

A comparison of some simple methods to identify geographical areas with excess incidence of a rare disease such as childhood leukaemia

1999

SUMMARY Six statistics are compared in a simulation study for their ability to identify geographical areas with a known excess incidence of a rare disease. The statistics are the standardized incidence ratio, the empirical Bayes method of Clayton and Kaldor, Poisson probability, a statistic based on the B statistics are compared for the proportion of true high-risk areas identi"ed in the top 1 per cent and 10 per cent of ranked areas. One of the PW statistics performed consistently well under all circumstances, although the results for the BT statistic were marginally better when only the top 1 per cent of ranked areas was considered. The standardized incidence ratio performed consistently …