Search results for "AES"
showing 10 items of 2262 documents
A Peptidoglycan-Remodeling Enzyme Is Critical for Bacteroid Differentiation in Bradyrhizobium spp. During Legume Symbiosis.
2016
International audience; In response to the presence of compatible rhizobium bacteria, legumes form symbiotic organs called nodules on their roots. These nodules house nitrogen-fixing bacteroids that are a differentiated form of the rhizobium bacteria. In some legumes, the bacteroid differentiation comprises a dramatic cell enlargement, polyploidization, and other morphological changes. Here, we demonstrate that a peptidoglycan-modifying enzyme in Bradyrhizobium strains, a DD-carboxypeptidase that contains a peptidoglycan-binding SPOR domain, is essential for normal bacteroid differentiation in Aeschynomene species. The corresponding mutants formed bacteroids that are malformed and hypertrop…
Minerality in wine: Towards the reality behind the myths
2018
Revue non indexée dans JCR. This article belongs to the Special Issue Wine Components and Chemical Mechanisms for Health; Tasting minerality in wine is highly fashionable, but it is unclear what this involves. The present review outlines published work concerning how minerality in wine is perceived and conceptualised by wine professionals and consumers. Studies investigating physico-chemical sources of perceived minerality in wine are reviewed also. Unusually, for a wine sensory descriptor, the term frequently is taken to imply a genesis: the sensation is the taste of minerals in the wine that were transported through the vine from the vineyard rocks and soils. Recent studies exploring tast…
Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect
2021
Aim Recent evidence suggests that arterial hypertension could be alternatively explained as a physiological adaptation response to water shortage, termed aestivation, which relies on complex multi-organ metabolic adjustments to prevent dehydration. Here, we tested the hypothesis that chronic water loss across diseased skin leads to similar adaptive water conservation responses as observed in experimental renal failure or high salt diet. Methods We studied mice with keratinocyte-specific overexpression of IL-17A which develop severe psoriasis-like skin disease. We measured transepidermal water loss and solute and water excretion in the urine. We quantified glomerular filtration rate (GFR) by…
Human Breast Milk NMR Metabolomic Profile across Specific Geographical Locations and Its Association with the Milk Microbiota
2018
The composition of human breast milk is highly variable, and it can be influenced by genetics, diet, lifestyle, and other environmental factors. This study aimed to investigate the impact of geographical location and mode of delivery on the nuclear magnetic resonance spectroscopy (NMR) metabolic profile of breast milk and its relationship with the milk microbiome. Human milk metabolic and microbiota profiles were determined using NMR and 16S rRNA gene sequencing, respectively, in 79 healthy women from Finland, Spain, South Africa, and China. Up to 68 metabolites, including amino acids, oligosaccharides, and fatty acid-associated metabolites, were identified in the milk NMR spectra. The meta…
In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae
2016
Sodium aescinate (SA) is a widely-applied triterpene saponin product derived from horse chestnut seeds, possessing vasoactive and organ-protective activities with oral or injection administration in the clinic. To date, no toxicity or adverse events in SA have been reported, by using routine models (in vivo or in vitro), which are insufficient to predict all aspects of its pharmacological and toxicological actions. In this study, taking advantage of transparent zebrafish larvae (Danio rerio), we evaluated cardiovascular toxicity of SA at doses of 1/10 MNLC, 1/3 MNLC, MNLC and LC10 by yolk sac microinjection. The qualitative and quantitative cardiotoxicity in zebrafish was assessed at 48 h p…
Bodies Making Spaces: Understanding the Airport as a Site of Dissonance
2019
AbstractTrakilović theorizes the airport as a site where cultural/European notions of belonging are negotiated and controlled. Focusing on Schiphol airport in Amsterdam, the chapter approaches both the airport itself as well as its nearby detention center as one complex cultural phenomenon, from which Schiphol emerges as a site of heritage dissonance. Taking a phenomenological approach, the chapter explores what it means to be an embodied subject at the airport, taking the narrative of a Syrian newcomer who is relocated to the detention center as well as the author’s own experience of the airport as its analytical starting points. The selective processes of in- and exclusion at the airport …
Introduction: Europe, Heritage and Memory—Dissonant Encounters and Explorations
2019
AbstractThe introduction to Dissonant Heritages and Memories in Contemporary Europe theoretically grounds the book’s various problematizations of heritage and identity struggles in Europe today, including the heritage policies of the EU and other intergovernmental organizations, struggles over ethnographic and historical exhibitions, activist practices, and dissonant memories. By discussing these struggles and their problematizations, the introduction connects the book to a wide range of ongoing debates across the humanities and social sciences. At the same time, it discusses how convergences and divergences within and between the volume’s chapters foster new insights regarding the concepts…
Książę Niccola Machiavellego jako przykład zastosowania toposu zakulisowości
2019
Aby wyjaśnić fenomen popularności Księcia Niccola Machiavellego, należy wskazać na osobliwy sposób komunikowania się autora tego dzieła z czytelnikiem. Autor przedstawia siebie jako fachowca z dziedziny sztuki politycznej, za swoich czytelników zaś chce mieć jedynie tych, którzy, jak on, znają się na rzeczy. Charakterystyczny zimny i, z pozoru przynajmniej, nieozdobny styl, jakim posługuje się autor Księcia, podkreśla dodatkowo profesjonalny i nieosobisty stosunek pisarza do przedmiotu jego rozważań. W kategoriach teorii retorycznej taki sposób komunikowania się daje się opisać jako poszukiwanie okrężnych dróg do tego, co Kenneth Burke określał mianem konsubstancjacji retorycznej. Mówca sta…
Sincerity in Lithuanian epistolarity: Between truth and emotion
2020
AbstractThis paper investigates the lexical representation of sincerity in Lithuanian epistolarity throughout the twentieth century. Drawing on data from the corpus of Lithuanian letters and employing the techniques of corpus, statistical and philological analysis, this paper explores the use, frequency and context of occurrence of the four sets of lexical stems: atvir- (‘open’, ‘frank’), nuošird- (‘sincere’, ‘honest’), šird- (‘heart’), and tikr- (‘authentic’, ‘genuine’, ‘real’). As each of these lexical stems foreground different semantic shades of sincerity, they are treated in this paper as lexical variables that inscribe different degrees of an author’s sincere attitude (stance) toward …
Hope and equilibrium in the dystopian world of The Hunger Games
2021
This paper provides evidence of the fruitfulness of combining analytical categories from Cognitive Linguistics and Critical Discourse Analysis for the analysis of complex literary characterizations. It does so through a detailed study of the “tributes”, i.e. the randomly selected children who have to fight to death in a nationally televised show, in The Hunger Games. The study proves the effectiveness of such categories to provide an analytically accurate picture of the dystopian world depicted in the novel, which is revealed to include a paradoxical element of hope. The type of dehumanization that characterizes the dystopian society of Panem is portrayed through an internally consistent se…