Search results for "AFRICA"
showing 10 items of 962 documents
Predicting 19F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase–Inhibitor Complex
2020
Abstract The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been challenging due to the high electron density of the fluorine atom. Nonetheless, reliable 19F chemical‐shift predictions to deduce ligand‐binding modes hold great potential for in silico drug design. Herein, we present a systematic QM/MM study to predict the 19F NMR chemical shifts of a covalently bound fluorinated inhibitor to the essential oxidoreductase tryparedoxin (Tpx) from African trypanosomes, the causative agent of African sleepi…
Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis
2019
This paper describes an optimization strategy of the highly active vinyl ketone 3 which was recognized as a strong inhibitor of rhodesain of Trypanosoma brucei rhodesiense, endowed with a ksecond v...
Development of Novel Benzodiazepine-Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense.
2020
Starting from the reversible rhodesain inhibitors 1 a-c, which have Ki values towards the target protease in the low-micromolar range, we have designed a series of peptidomimetics, 2 a-g, that contain a benzodiazepine scaffold as a β-turn mimetic; they are characterized by a specific peptide sequence for the inhibition of rhodesain. Considering that irreversible inhibition is strongly desirable in the case of a parasitic target, a vinyl ester moiety acting as Michael-acceptor was introduced as the warhead; this portion was functionalized in order to evaluate the size of corresponding enzyme pocket that could accommodate this substituent. With this investigation, we identified an irreversibl…
Distribution et abondance des mouches piqueuses (Glossinidae, Stomoxys et Tabanidae) dans deux parcs nationaux du Gabon.
2015
11 pages; International audience; In order to minimize risks of pathogen transmission with the development of ecotourism in Gabon, a seasonal inventory has been performed in five contrasted biotopes in Ivindo (INP) and Moukalaba-Doudou (MDNP) National Parks. A total of 10,033 hematophagous flies were captured. The Glossinidae, with six different species identified, was the most abundant group and constitutes about 60% of the captured flies compared to the Stomoxys (6 species also identified) and Tabanidae with 28% and 12%, respectively. The Glossinidae showed a higher rate of capture in primary forest and in research camps. In INP, the Stomoxys showed a higher rate of capture in secondary f…
Il teatro romano di Althiburos (El Medeina, El Kef, Tunisia)
2016
Il contributo presenta le attività della missione archeologica dell'Università di Macerata ad Althiburos per lo studio, lo scavo e la valorizzazione del teatro romano della città. Una missione svolta in collaborazione con l'Institut National du Patrimoine de Tunis ed il Politecnico di Bari a partire dal 2006. Le tre campagne di scavo (2007, 2009 e 2010, alle quali va aggiunta una campagna di ricognizione e ricerca di confronti nel 2014, con il cofinanziamento del MAE) hanno permesso di indagare le fasi più recenti della vita dell'edificio e di redigere un primo rilievo del monumento.
Nouveaux enjeux pour l'école moyenne en Afrique
2005
05113; On constate aujourd'hui une augmentation massive de la scolarité des 12-16 ans dans les pays africains en développement. Ce phénomène est lié au développement voulu et obtenu des scolarités primaires.Pour diverses raisons, l'école moyenneconstitue un cycle terminal pour la grande majorité des enfants qui la fréquentent. Son organisation actuelle, telle qu'on peut l'observer dans différents pays, est cependant très proche du collège secondaire français et donc inapte à fournir le cadre adéquat pour un cycle terminal générateur de progrès économiques et sociaux.Bâti sur cette problématique de l'articulation entre les flux d'élèves, les contenus pédagogiques et les modalités d'organisat…
La conferenza Pan-Africana sulla gestione integrate delle coste (PACSICOM)
1999
Non disponibile
La protezione della fauna nella Repubblica Centrafricana: un caso sui generis di protezione ambientale in Africa
1996
L'articolo analizza il regime giuridico della protezione dell'ambiente nella Repubblica Centrafricana.
La lotta contro il bracconaggio in Africa: uno sguardo d’insieme
2000
Non disponibile
Radical analyticity and radical pro-drop scenarios of diachronic change in East and mainland Southeast Asia, West Africa and Pidgins and Creoles
2020
Abstract The paucity or absence of inflectional morphology (radical analyticity) and the omission of verbal arguments with no concomitant agreement (radical pro-drop) are well-known characteristics of East and mainland Southeast Asian languages (EMSEA). Both of them have a special status in typology and linguistic theory. Radical analyticity is known under the term of ‘morphological isolation’ and has recently been described as ‘diachronically anomalous’ (McWhorter 2016), while radical pro-drop is a theoretical challenge since Rizzi (1986). The present paper offers an alternative view on these characteristics based on data from EMSEA languages, radically analytic West African languages and …