Search results for "AIC"

QuBiLS-MAS, open source multi-platform software for atom- and bond-based topological (2D) and chiral (2.5D) algebraic molecular descriptors computati…

2017

Background In previous reports, Marrero-Ponce et al. proposed algebraic formalisms for characterizing topological (2D) and chiral (2.5D) molecular features through atom- and bond-based ToMoCoMD-CARDD (acronym for Topological Molecular Computational Design-Computer Aided Rational Drug Design) molecular descriptors. These MDs codify molecular information based on the bilinear, quadratic and linear algebraic forms and the graph-theoretical electronic-density and edge-adjacency matrices in order to consider atom- and bond-based relations, respectively. These MDs have been successfully applied in the screening of chemical compounds of different therapeutic applications ranging from antimalarials…

Identification of control targets in Boolean molecular network models via computational algebra

2015

Motivation: Many problems in biomedicine and other areas of the life sciences can be characterized as control problems, with the goal of finding strategies to change a disease or otherwise undesirable state of a biological system into another, more desirable, state through an intervention, such as a drug or other therapeutic treatment. The identification of such strategies is typically based on a mathematical model of the process to be altered through targeted control inputs. This paper focuses on processes at the molecular level that determine the state of an individual cell, involving signaling or gene regulation. The mathematical model type considered is that of Boolean networks. The pot…

RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation

2018

Aicardi-Goutières syndrome (AGS) is a rare early onset childhood encephalopathy caused by persistent neuroinflammation of autoimmune origin. AGS is a genetic disorder and >50% of affected individuals bear hypomorphic mutations in ribonuclease H2 (RNase H2). All available RNase H2 mouse models so far fail to mimic the prominent CNS involvement seen in AGS. To establish a mouse model recapitulating the human disease, we deleted RNase H2 specifically in the brain, the most severely affected organ in AGS. Although RNase H2δGFAPmice lacked the nuclease in astrocytes and a majority of neurons, no disease signs were apparent in these animals. We additionally confirmed these results…

Postzygotic BRAF p.Lys601Asn Mutation in Phacomatosis Pigmentokeratotica with Woolly Hair Nevus and Focal Cortical Dysplasia

2016

International audience

A putative antiviral role of plant cytidine deaminases

2014

[Background]: A mechanism of innate antiviral immunity operating against viruses infecting mammalian cells has been described during the last decade. Host cytidine deaminases (e.g., APOBEC3 proteins) edit viral genomes, giving rise to hypermutated nonfunctional viruses; consequently, viral fitness is reduced through lethal mutagenesis. By contrast, sub-lethal hypermutagenesis may contribute to virus evolvability by increasing population diversity. To prevent genome editing, some viruses have evolved proteins that mediate APOBEC3 degradation. The model plant Arabidopsis thaliana genome encodes nine cytidine deaminases ( AtCDAs), raising the question of whether deamination is an antiviral mec…

Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg

1990

3-Phase grid-connected building integrated photovoltaic system with reactive power control capability

2020

Abstract Recently, a tendency in the growing of grid-connected building integrated photovoltaic (BIPV) systems has been noticed in most countries. Hence, high penetration of PV power into the system network can be observed in many points in the network. This may cause severe problems on the distribution network due to the intermittent nature of PV systems. As a feasible solution, the reactive power capability of voltage source inverter in PV systems can be employed rather than approaching expensive grid infrastructures in the distribution network. The purpose of this study is to implement a 3-phase grid-connected (BIPV) system with reactive power control to regulate the system voltage and i…

On the Betti numbers of three fat points in P1 × P1

2019

In these notes we introduce a numerical function which allows us to describe explicitly (and nonrecursively) the Betti numbers, and hence, the Hilbert function of a set Z of three fat points whose support is an almost complete intersection (ACI) in P1 × P1 . A nonrecursively formula for the Betti numbers and the Hilbert function of these configurations is hard to give even for the corresponding set of five points on a special support in P2 and we did not find any kind of this result in the literature. Moreover, we also give a criterion that allows us to characterize the Hilbert functions of these special set of fat points.

Infinitesimal deformations of double covers of smooth algebraic varieties

2003

The goal of this paper is to give a method to compute the space of infinitesimal deformations of a double cover of a smooth algebraic variety. The space of all infinitesimal deformations has a representation as a direct sum of two subspaces. One is isomorphic to the space of simultaneous deformations of the branch locus and the base of the double covering. The second summand is the subspace of deformations of the double covering which induce trivial deformations of the branch divisor. The main result of the paper is a description of the effect of imposing singularities in the branch locus. As a special case we study deformations of Calabi--Yau threefolds which are non--singular models of do…

OPERADS AND JET MODULES

2005

Let $A$ be an algebra over an operad in a cocomplete closed symmetric monoidal category. We study the category of $A$-modules. We define certain symmetric product functors of such modules generalising the tensor product of modules over commutative algebras, which we use to define the notion of a jet module. This in turn generalises the notion of a jet module over a module over a classical commutative algebra. We are able to define Atiyah classes (i.e. obstructions to the existence of connections) in this generalised context. We use certain model structures on the category of $A$-modules to study the properties of these Atiyah classes. The purpose of the paper is not to present any really de…