Search results for "AIH"
showing 10 items of 785 documents
Endogenous AhR agonist FICZ accumulates in rainbow trout (Oncorhynchus mykiss) alevins exposed to a mixture of two PAHs, retene and fluoranthene
2022
AbstractMultiple studies have reported synergized toxicity of PAH mixtures in developing fish larvae relative to the additive effect of the components. From a toxicological perspective, multiple mechanisms are known to contribute to synergism, such as altered toxicodynamics and kinetics, as well as increased oxidative stress. An understudied contributor to synergism is the accumulation of endogenous metabolites, for example: the aryl hydrocarbon receptor 2 (AhR2) agonist and tryptophan metabolite 6-Formylindolo(3,2-b)carbazole (FICZ). Fish larvae exposed to FICZ, alongside knock-down of cytochrome p450 (cyp1a), has been reported to induced symptoms of toxicity similar to those observed foll…
Changes in Cardiac Proteome and Metabolome Following Exposure to the Pahs Retene and Fluoranthene and Their Mixture in Developing Rainbow Trout Alevi…
2022
Exposure to polycyclic aromatic hydrocarbons (PAHs) is known to affect developing organisms. Utilization of different omics-based technologies and approaches could therefore provide a base for the discovery of novel mechanisms of PAH induced development of toxicity. To this aim, we investigated how exposure towards two PAHs with different toxicity mechanisms: retene (an aryl hydrocarbon receptor 2 (Ahr2) agonist), and fluoranthene (a weak Ahr2 agonist and cytochrome P450 inhibitor (Cyp1a)), either alone or as a mixture, affected the cardiac proteome and metabolome in newly hatched rainbow trout alevins (Oncorhynchus mykiss). In total, we identified 65 and 82 differently expressed proteins (…
Der pikareske Roman als Katalysator in geschichtlichen Abläufen : erzählerische Kommunikationsmodelle in Das Leben des Lazarillo von Tormes, bei Thom…
2005
Anna-Riitta Tunturi tutki väitöskirjassaan pikareski- eli veijariromaanin eri ilmenemismuotoja historiallisena läpileikkauksena, sosiologisena ilmiönä ja romaanitaiteen osa-alueena. Sana ”pícaro” tulee kastiliankielen verbistä ”picar”, joka tarkoittaa alempiarvoisten ammattien harjoittamista, kuten picador de toros, pikadori härkätaistelussa, toreadorin avustaja. Saksaksi sana on Schelm, joten oma sanamme kelmi on saksalaista lainaa. Lisäksi suomen kielessä on veijari, huijari, heittiö tai hulttio, ja lisääkin varmasti löytyy. This dissertation in comparative literature examines several Finnish picaresque novels of 20th century in relation to some classical continental European novels such …
Multiobjective shape design in a ventilation system with a preference-driven surrogate-assisted evolutionary algorithm
2019
We formulate and solve a real-world shape design optimization problem of an air intake ventilation system in a tractor cabin by using a preference-based surrogate-assisted evolutionary multiobjective optimization algorithm. We are motivated by practical applicability and focus on two main challenges faced by practitioners in industry: 1) meaningful formulation of the optimization problem reflecting the needs of a decision maker and 2) finding a desirable solution based on a decision maker’s preferences when solving a problem with computationally expensive function evaluations. For the first challenge, we describe the procedure of modelling a component in the air intake ventilation system wi…
Cold exposure enhances fat utilization but not non-esterified fatty acids, glycerol or catecholamines availability during submaximal walking and runn…
2013
Cold exposure modulates the use of carbohydrates and fat during exercise. This phenomenon has mostly been observed in controlled cycling studies, but not during walking and running when core temperature and oxygen consumption are controlled, as both may alter energy metabolism. This study aimed at examining energy substrate availability and utilization during walking and running in the cold when core temperature and oxygen consumption are maintained. Ten lightly clothed male subjects walked or ran for 60-min, at 50% and 70% of maximal oxygen consumption, respectively, in a climatic chamber set at 0°C or 22°C. Thermal, cardiovascular, and oxidative responses were measured every 15-…
Variability in δ13C values between individual Daphnia ephippia: Implications for palaeo-studies
2018
The stable carbon isotope ratio (δ13C value) of Daphnia spp. resting egg shells (ephippia) provides information on past changes in Daphnia diet. Measurements are typically performed on samples of ≥20 ephippia, which obscures the range of values associated with individual ephippia. Using a recently developed laser ablation-based technique, we perform multiple δ13C analyses on individual ephippia, which show a high degree of reproducibility (standard deviations 0.1–0.5‰). We further measured δ13C values of 13 ephippia from surface sediments of three Swiss lakes. In the well-oxygenated lake with low methane concentrations, δ13C values are close to values typical for algae (−31.4‰) and the rang…
Päiväkirjagenren moniäänisyys
2016
Yksityisen tekstilajin salassa muotoutuvia piirteitä on vaikeampi seurata kuin vapaasti luettavien lehtitekstien tai julkisten asiakirjojen genremuutoksia. Intiimit tekstilajit jäävät helposti tutkimatta. Tässä tutkielmassa tarkastellaan päiväkirjaa yksityisenä tekstilajina. Päiväkirja on tunnistettava ja iäkäs, mutta samalla henkilökohtainen ja kirjoittajansa tarkoituksiin mukautuva genre, mikä tekee sen vakaudesta suhteellista. Suhteellinen vakaus on Bahtinin mukaan genren ominaispiirre. Jotkin genret ovat vakaampia ja toiset dynaamisia. Genret tasapainoilevat kahden niihin vaikuttavan voiman välillä. Keskihakuinen voima pyrkii säilyttämään genren yhtenäisenä ja keskipakoinen voima paljas…
Suorittaminen, riippuvuus ja seurakunta : essee Päättymättömästä riemusta
2021
Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
2015
The adverse effects to humans and environment of only few chemicals are well known. Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco/toxicokinetics that determine the internal dose of chemicals to which the organism is exposed. Of all the xenobiotic-metabolizing enzymes, the cytochrome P450 (CYP) enzymes are the most important due to their abundance and versatility. Reactions catalyzed by CYPs usually turn xenobiotics to harmless and excretable metabolites, but sometimes an innocuous xenobiotic is transformed into a toxic metabolite. Data on ADME and toxicity properties of compounds are increasingly generated using in vitro and modeling (in silico) tools.…