Search results for "AIH"

Musiikki ja muut taiteet tukemassa esikoulusta ensimmäiselle luokalle siirtymistä

2008

Lasten metakognitiivisen tiedon kehitykselliset muutokset esikoulusta peruskoulun toiselle luokalle

2003

Lapsen siirtymä esiopetuksen toimintakulttuuriin : lasten näkemyksiä esiopetuksesta ja esikoululaisuudesta

2011

Holopainen, Katri. 2011. LAPSEN SIIRTYMÄ ESIOPETUKSEN TOIMINTAKULTTUURIIN. Lasten näkemyksiä esiopetuksesta ja esikoululaisuudesta. Varhaiskasvatustieteen pro gradu –tutkielma, Jyväskylän yliopisto, Kasvatustieteiden laitos, Varhaiskasvatuksen yksikkö. 124 sivua. Tutkimuksen aiheena oli tarkastella lapsen siirtymää esiopetuksen toimintakulttuuriin. Tehtävänä oli selvittää lasten käsityksiä esiopetuksesta ja siihen siirtymästä. Lisäksi tutkimuksessa tarkasteltiin, miten esikoululaisuus näyttäytyi lapselle, ja kuinka esikoululaisuus rakentui siinä kulttuurisessa kontekstissa, jossa lapsi elää. Lapsen toiminta ympäristöönsä aktiivisena osallistujana oli tutkimuksen tärkeä lähtökohta. Ensimmäin…

Lasten ongelmakäyttäytymisen kehityspolut ja niiden taustalla vaikuttavat tekijät

2002

Menopause modulates the circulating metabolome: evidence from a prospective cohort study

2022

Abstract Aims We studied the changes in the circulating metabolome and their relation to the menopausal hormonal shift in 17β-oestradiol and follicle-stimulating hormone levels among women transitioning from perimenopause to early postmenopause. Methods and results We analysed longitudinal data from 218 Finnish women, 35 of whom started menopausal hormone therapy during the study. The menopausal transition was monitored with menstrual diaries and serum hormone measurements. The median follow-up was 14 months (interquartile range: 8–20). Serum metabolites were quantified with targeted nuclear magnetic resonance metabolomics. The model results were adjusted for age, follow-up duration, educat…

Estradiol deficiency and skeletal muscle apoptosis: Possible contribution of microRNAs.

2020

Background Menopause leads to estradiol (E2) deficiency that is associated with decreases in muscle mass and strength. Here we studied the effect of E2 deficiency on miR-signaling that targets apoptotic pathways. Methods C57BL6 mice were divided into control (normal estrous cycle, n = 8), OVX (E2 deficiency, n = 7) and OVX + E2 groups (E2-pellet, n = 4). Six weeks following the OVX surgery, mice were sacrificed and RNA isolated from gastrocnemius muscles. miR-profiles were studied with Next-generation sequencing (NGS) and candidate miRs verified using qPCR. The target proteins of the miRs were found using in silico analysis and measured at mRNA (qPCR) and protein levels (Western blot). Resu…

Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort : novel results show menopause-re…

2018

Objective: The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. This paper describes the protocol and nonrespondent analysis of ERMA and novel findings on menopausal differences in blood count variables and their association with female sex hormones. Methods: Women aged 47 to 55 years were assigned to pre, early peri, late peri, and postmenopausal groups based on follicle-stimulating hormone (FSH) and bleeding diary. Multivariate linear regression models were constructed to estimate the association of 17b-estradiol (E…

Estrogen regulates muscle bioenergetic signaling

2018

Extracellular vesicles and high‐density lipoproteins: Exercise and oestrogen‐responsive small RNA carriers

2023

Decreased systemic oestrogen levels (i.e., menopause) affect metabolic health. However, the detailed mechanisms underlying this process remain unclear. Both oestrogens and exercise have been shown to improve metabolic health, which may be partly mediated by circulating microRNA (c-miR) signalling. In recent years, extracellular vesicles (EV) have increased interest in the field of tissue crosstalk. However, in many studies on EV-carried miRs, the co-isolation of high-density lipoprotein (HDL) particles with EVs has not been considered, potentially affecting the results. Here, we demonstrate that EV and HDL particles have distinct small RNA (sRNA) content, including both host and nonhost sRN…

Data from Estrogenic Regulation of Muscle Apoptosis (ERMA) study

2022

The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. In addition, health behaviour (e.g., physical activity and eating behaviour) and blood-based biomarkers are investigated. Biomarker data includes different omics datasets (e.g. metabolomics, genomics, transcriptomics). The complete data set includes baseline data collection and two different follow-ups. The baseline ERMA study (=parent data) is a population-based cohort study, which forms a parent data set for the follow-up studies (ERMA follow-up and EsmiRs). Data …