Search results for "AIH"
showing 10 items of 785 documents
Prokaryotic assemblages within permafrost active layer at Edmonson Point (Northern Victoria Land, Antarctica)
2018
This study was aimed at gaining insights on the prokaryotic community (in terms of both taxonomic composition and activities) inhabiting the active layer at Edmonson Point, an ice-free area on the eastern slope at the foot of Mount Melbourne (Northern Victoria Land, Antarctica). Samples were collected during the thawing period, when microbial physiological activities are restored to utilize previously frozen organic substrates. Despite the very small cell sizes (600 daltons) substrates, as indicated also by the obtained rates of enzymatic hydrolytic activities over proteolytic, glycolitic and phosphoric compounds. Taxonomical composition showed that Proteobacteria, Actinobacteria and Firmic…
Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement
2018
Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause-and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls. Seven miRs, expressed in both adipose tissue and serum, were selected for validation phase in 34 women from a different cohort. An age/menopause-related increase of …
Monitoring of ticks and tick-borne pathogens through a nationwide research station network in Finland.
2020
In 2015 a long-term, nationwide tick and tick-borne pathogen (TBP) monitoring project was started by the Finnish Tick Project and the Finnish Research Station network (RESTAT), with the goal of producing temporally and geographically extensive data regarding exophilic ticks in Finland. In the current study, we present results from the first four years of this collaboration. Ticks were collected by cloth dragging from 11 research stations across Finland in May September 2015-2018 (2012-2018 in Seili). Collected ticks were screened for twelve different pathogens by qPCR: Borrelia afzelii, Borrelia garinii, Borrelia valaisiana, Borrelia burgdorferi sensu stricto, Borrelia miyamotoi, Babesia sp…
Combining expertise from linguistics and tourism: a tale of two cities
2020
This case study presents the results of an interdisciplinary Virtual Exchange (VE) that was arranged between Finnish and Polish students in 2019. During their six-week collaboration, the students of language studies at the University of Jyväskylä, Finland, worked in teams together with their Polish peers specialising in information and communications technology and management in tourism at Adam Mickiewicz University in Poznań, Poland. The international teams combined their linguistic and tourism-promotion expertise, and, using collaborative digital tools, grappled with the tasks of analysing the official municipal city websites and promoting the lesser-known aspects of their sister cities (…
Predicting habitat suitability for Ixodes ricinus and Ixodes persulcatus ticks in Finland
2022
AbstractBackgroundTicks are responsible for transmitting several notable pathogens worldwide. Finland lies in a zone where two human-biting tick species co-occur:IxodesricinusandIxodespersulcatus. Tick densities have increased in boreal regions worldwide during past decades, and tick-borne pathogens have been identified as one of the major threats to public health in the face of climate change.MethodsWe used species distribution modelling techniques to predict the distributions ofI.ricinusandI.persulcatus,using aggregated historical data from 2014 to 2020 and new tick occurrence data from 2021. By aiming to fill the gaps in tick occurrence data, we created a new sampling strategy across Fin…
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
2023
Nicotinamide adenine dinucleotide (NAD + ) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice. However, most short-term clinical trials conducted so far have not reported positive outcomes. Therefore, we aimed to determine whether long-term NR supplementation boosts mitochondrial biogenesis and metabolic health in humans. Twenty body mass index (BMI)–discordant monozygotic twin pairs were supplemented with an escalating dose of NR (250 to 1000 mg/day) for 5 months. NR improved systemic NAD + metabolism, muscle mitochondrial number, myoblast differentiation, and gut microbiota compos…
Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease
2023
Numerous studies have described specific metabolites as biomarkers ofsevere liver diseases, but very few have measured gut microbiota (GM)-produced metab-olites in fatty liver disease. We aimed atfinding GM signatures and metabolite markersin plasma and feces related to high liver fat content. Based on imaging, we dividedstudy participants into low (,5%, LF,n= 25) and high (.5%, HF,n= 39) liver fatgroups. Fecal (LFn= 14, HFn= 25) and plasma (LFn= 11, HFn= 7) metabolomes ofsubsets of participants were studied using liquid chromatography/high resolution massspectrometry. The GM were analyzed using 16S rRNA gene sequencing. Additionally,blood clinical variables and diet were studied. Dyslipide…
Mikä 12-vuotiaan mieltä painaa? : tutkimus kuudesluokkalaisten huolenaiheista ja niiden käsittelytavoista
2003
Todeksi uskottua : kansandemokraattinen Neuvostoliitto-journalismi rajapinnan tulkkina vuosina 1964-1973
2008
Aimo Ruususen väitöstutkimus paljastaa, miten ideologiset ja muut riippuvuudet näkyivät suomalaisten kansandemokraattisten toimittajien työssä kylmän sodan vuosina ja Neuvostoliiton historian mielenkiintoisena ajanjaksona 1960-luvun puolivälistä alkaen.- Kansandemokraattisissa sanomalehdissä vaiettiin joistakin Neuvostoliiton kannalta epäedullisista asioista, vaikka sellaisistakin eräissä kriisitapauksissa kerrottiin, Ruusunen kertoo.Tämän lehtiryhmän toimittajat olivat kahden erilaisen kulttuurin välisellä rajapinnalla ja sen tulkkeina erikoisessa asemassa. Toisaalta heillä oli paljon mahdollisuuksia tiedon saantiin, toisaalta heillä oli ideologisia esteitä asioiden julkiseen pohdintaan. K…
Neuvosto-Viron pioneerijärjestön ja Suomen Demokratian Pioneerien Liiton kanssakäyminen liennytyksestä Prahan kevääseen
2011
Tutkielmassa käsitellään Neuvosto-Viron pioneerijärjestön ja Suomen Demokratian Pioneerien Liiton (SDPL) välisiä suhteita vuosina 1955–1968. Työn keskeisin kysymys koskee sitä, minkälaista ideologista sekä toiminnallista kanssakäymistä oli Neuvosto-Viron pioneerijärjestön ja Suomen Demokratian Pioneerien Liiton välillä. Ja ennen kaikkea mitä kanssakäymisellä haettiin sekä minkälaisiin tuloksiin lopulta päästiin? Tutkimuksessa haetaan myös vertailevilla ja lähdekriittisillä tutkimusmenetelmillä vastausta kysymykseen, millaisia eroja tai yhtäläisyyksiä oli poliittisesti vastakkaisiin leireihin kuuluneiden maiden pioneerijärjestöjen toimintojen ja toimintaperiaatteiden välillä. Oliko pioneeris…