Search results for "AIM"
showing 10 items of 1022 documents
BRIMA : Low-Overhead Browser-Only Image Annotation Tool
2021
Image annotation and large annotated datasets are crucial parts within the Computer Vision and Artificial Intelligence fields. At the same time, it is well-known and acknowledged by the research community that the image annotation process is challenging, time-consuming and hard to scale. Therefore, the researchers and practitioners are always seeking ways to perform the annotations easier, faster, and at higher quality. Even though several widely used tools exist and the tools’ landscape evolved considerably, most of the tools still require intricate technical setups and high levels of technical savviness from its operators and crowdsource contributors.In order to address such challenges, w…
Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer.
2022
Abstract Background Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell co-localisation and T cell densities. Methods We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 µm radius (to derive T cell p…
Immunological and prognostic significance of tumour necrosis in colorectal cancer
2023
Abstract Background Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis in CRC. Methods Three independent CRC cohorts, including 1413 patients, were analysed. Associations of the areal percentage of tumour necrosis with clinicopathologic parameters, tumour infiltrating immune cells, cytokine concentrations in systemic and mesenteric vein blood, and survival were examined. Results Higher tumour necrosis percentag…
Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
2023
Abstract Background The CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction may promote cancer progression, but the expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. Methods We used a custom 9-plex immunohistochemistry assay to quantify the expression patterns of PD-L1 and PD-1 in macrophages, T cells, and tumour cells in 910 colorectal cancer patients. We evaluated cancer-specific mortality according to immune cell subset densities using multivariable Cox regression models. Results Compared to PD-L1– macrophages, PD-L1+ macrophages were more likely M1-polarised than M2-polarised and located close…
Understanding Degassing Pathways Along the 1886 Tarawera (New Zealand) Volcanic Fissure by Combining Soil and Lake CO2 Fluxes
2019
CO2 flux measurements are often used to monitor volcanic systems, understand the cause of volcanic unrest, and map sub-surface structures. Currently, such measurements are incomplete at Tarawera (New Zealand), which erupted with little warning in 1886 and produced a ∼17 km long fissure. We combine new soil CO2 flux and C isotope measurements of Tarawera with previous data from Rotomahana and Waimangu (regions also along the 1886 fissure) to fingerprint the CO2 source, understand the current pathways for degassing, quantify the CO2 released along the entire fissure, and provide a baseline survey. The total CO2 emissions from the fissure are 1227 t⋅d–1 (742–3398 t⋅d–1 90 % confidence interval…
Funebre memoria de la buena vida, muerte, y exequias del V. P. ... Fr. Jayme Castelló ... del Convento de la Virgen del Remedio de Valencia, del Ord…
1707
El f. de làm. és el retrat de Fr. Jaime Castelló Port. amb orla tip. Caplletres ornades, fris Sign.: [estrella]-2[estrella]4, A-E4, F2 Text amb postil·les marginals Reclams
Experimental Investigation on Water Loss and Stiffness of CBTM Using Different RA Sources
2021
Cold recycling of reclaimed asphalt (RA) is a promising technique to build or to maintain roads, combining performance and environmental advantages. Although this technique has been extensively used worldwide, there is no unique and internationally-shared method to characterize cold recycled mixtures. The previous work of the RILEM TC 237-SIB TG6 successfully attempted to characterize different RA sources with both traditional parameters (gradation, bitumen content and geometrical properties) and non-conventional properties (fragmentation and strength testing). The current RILEM TC 264-RAP TG1 mainly focuses on the influence of different RA sources on physical and mechanical characteristics…
USING ROTATING SPRINKLER GUNS IN CENTRE‐PIVOT IRRIGATION SYSTEMS †
2019
The use of centre-pivot irrigation systems has significantly increased in the last few decades, since they are easier and less time-consuming to manage compared to other irrigation systems. Standard high-pressure impact sprinklers, low-pressure spray sprinklers or LEPA (Low Energy Precision Application) systems are usually combined with a centre-pivot irrigation system (CP-SYS). However, when applying waste water or with reclaimed effluents that are extremely dirty, small nozzle sizes that require CP-SYS could get plugged. As an alternative to common centre-pivot irrigation systems, this paper analyses the ‘geometry’ of areas irrigated by rotating sprinkler guns in a centre-pivot irrigation…
DNA barcoding reveals different cestode helminth species in northern European marine and freshwater ringed seals
2021
Three subspecies of the ringed seal (Pusa hispida) are found in northeastern Europe: P. h. botnica in the Baltic Sea, P. h saimensis in Lake Saimaa in Finland, and P. h. ladogensis in Lake Ladoga in Russia. We investigated the poorly-known cestode helminth communities of these closely related but ecologically divergent subspecies using COI barcode data. Our results show that, while cestodes from the Baltic Sea represent Schistocephalus solidus, all worms from the two lakes are identified as Ligula intestinalis, a species that has previously not been reported from seals. The observed shift in cestode communities appears to be driven by differential availability of intermediate fish host spec…
Revisiting the happy-productive worker thesis from a eudaimonic perspective: a systematic review
2021
The happy-productive worker thesis (HPWT) is considered the Holy Grail of management research, and it proposes caeteris paribus, happy workers show higher performance than their unhappy counterparts. However, eudaimonic well-being in the relationship between happiness and performance has been understudied. This paper provides a systematized review of empirical evidence in order to make a theoretical contribution to the happy-productive worker thesis from a eudaimonic perspective. Our review covers 105 quantitative studies and 188 relationships between eudaimonic well-being and performance. Results reveal that analyzing the eudaimonic facet of well-being provides general support for the HPWT…