Search results for "AKA"
showing 10 items of 2351 documents
eCRM:n ja verkkokaupan rooli asiakastyytyväisyyden luomisessa
2010
Heikkinen, Hanna Karoliina Tietojärjestelmätieteen kandidaatintutkielma /Hanna Karoliina Heikkinen Jyväskylä: Jyväskylän yliopisto, 2009, 38 s. Kandidaatintutkielma Yrityksien liiketoiminta- ja ajattelumallit ovat siirtyneet tuotantokeskeisestä asiakaskeskeiseen. Tässä tutkielmassa tarkastellaan asiakaskeskeistä liiketoimintaa eri näkökulmista. Asiakaskeskeiseen liiketoimintaan kuuluu olennaisena osana CRM-käsite (Customer Relationship Management), jolle on kirjallisuudessa esitetty useita erilaisia määritelmiä. Tässä tutkielmassa CRM:ää käsitellään yrityksen kokonaisvaltaisena strategiana harjoittaa liiketoimintaa. CRM-liiketoimintastrategiaan sisältyy olennaisena osana myös teknologiset …
Sähköiset markkinointiviestintäteknologiat lisäarvon luojina arjen asumisessa : case Asuntosäätiön Asumisoikeus Oy
2013
Tämä pro gradu -tutkielma tehdään toimeksiantona Asuntosäätiön Asumisoikeus Oy:lle. Tässä pro gradu -tutkielmassa on tarkoituksena tutkia sitä, voidaanko markkinointiviestinnän teknologioilla luoda lisäarvoa arjen asumiseen esimerkiksi yhteisöllisyyden ja vuorovaikutuksen kautta. Tässä pro-gradu tutkielmassa on myös tarkoituksena selvittää, mitkä markkinointiviestinnän teknologioiden ominaisuudet luovat lisäarvoa yhteisöllisyyden ja vuorovaikutuksen kautta. Asiakassuhdemarkkinoinnin ja sähköisen viestinnän pelikenttä on muuttunut oleellisesti Internetin ja sen sovellusten kehittymisen myötä. Tämän hetkinen asiakassuhdemarkkinointi ja markkinoinnin aikakausi on erittäin ihmiskeskeistä. Jokai…
Prevention of chemotherapy-induced anemia and thrombocytopenia by constant administration of stem cell factor.
2011
Abstract Purpose: Chemotherapy-induced apoptosis of immature hematopoietic cells is a major cause of anemia and thrombocytopenia in cancer patients. Although hematopoietic growth factors such as erythropoietin and colony-stimulating factors cannot prevent the occurrence of drug-induced myelosuppression, stem cell factor (SCF) has been previously shown to protect immature erythroid and megakaryocytic cells in vitro from drug-induced apoptosis. However, the effect of SCF in vivo as a single myeloprotective agent has never been elucidated. Experimental Design: The ability of SCF to prevent the occurrence of chemotherapy-induced anemia and thrombocytopenia was tested in a mouse model of cisplat…
Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic proge…
2001
Stromal cell-derived factor-1alpha (SDF-1alpha) is a potent chemoattractant for hematopoietic progenitor cells (HPC), suggesting that it could play an important role during their migration within or to the bone marrow (BM). The integrin VLA-4 mediates HPC adhesion to BM stroma by interacting with CS-1/fibronectin and VCAM-1. It is required during hematopoiesis and homing of HPC to the BM. As HPC migration in response to SDF-1alpha might require dynamic regulation of integrin function, we investigated if SDF-1alpha could modulate VLA-4 function on BM CD34(hi) cells.CD34(hi) BM cells and hematopoietic cell lines were tested for the effect of SDF-1alpha on VLA-4-dependent adhesion to CS-1/fibr…
A natural-like synthetic small molecule impairs bcr-abl signaling cascades and induces megakaryocyte differentiation in erythroleukemia cells
2013
Over the past years, we synthesized a series of new molecules that are hybrids of spirocyclic ketones as complexity-bearing cores with bi- and ter-phenyls as privileged fragments. Some of these newly-shaped small molecules showed antiproliferative, pro-apoptotic and differentiating activity in leukemia cell lines. In the present study, to investigate more in depth the mechanisms of action of these molecules, the protein expression profiles of K562 cells treated with or without the compounds IND_S1, MEL_T1, IND_S7 and MEL_S3 were analyzed using two-dimensional gel electrophoresis coupled with mass spectrometry. Proteome comparisons revealed several differentially expressed proteins, mainly r…
Does Optimal Volume Fraction in Percutaneous Vertebroplasty Prevent Cement Leakage?
2018
Mutual entity authentication for LTE
2011
In this paper we outline the Authentication and Key Agreement protocol (EPS-AKA) found in Long-Term Evolution (LTE) systems. This architecture is the 3GPP version of a 4G access security architecture. The LTE security architecture is a mature evolved architecture, with both strengths and weaknesses. In this paper we propose an amendment to the EPS-AKA protocol to make it a full mutual (online) entity authentication protocol. We also analyze the proposal, highlighting both the improvements and the drawbacks of the new AKA protocol.
On the statistical properties of the capacity of OSTBC Nakagami-lognormal MIMO channels
2010
This article presents a thorough statistical analysis of the capacity of orthogonal space-time block coded (OSTBC) Nakagami-lognormal (NLN) multiple-input multipleoutput (MIMO) channels. The NLN channel model allows to study the joint effects of fast fading and shadowing on the statistical properties of the channel capacity. We have derived exact analytical expressions for the probability density function (PDF), cumulative distribution function (CDF), level-crossing rate (LCR), and average duration of fades (ADF) of the capacity of NLN MIMO channels. It is observed that an increase in the MIMO dimension1 or a decrease in the severity of fading results in an increase in the mean channel capa…
The Influence of the Severity of Fading and Shadowing on the Statistical Properties of the Capacity of Nakagami-Lognormal Channels
2008
This paper deals with the study of the statistical properties of the capacity of Nakagami-lognormal (NLN) channels for various fading environments. Specifically, the impact of shadowing and the severity of fading on the channel capacity is investigated. We have derived analytical expressions for the probability density function (PDF), cumulative distribution function (CDF), level-crossing rate (LCR), and average duration of fades (ADF) of the channel capacity. These results are analyzed for different levels of shadowing and for various fading conditions, corresponding to different terrestrial environments. It is observed that the severity of fading and shadowing has a significant influence …
Hyper-IL-6 (H-IL-6), a Fusion Protein of Soluble IL-6 Receptor (Sil-6R), and Interleukin-6 (IL-6), Acts Synergistic with Thrombopoietin (TPO) and Ste…
1999
It has been shown that signalings from c-kit and gpl30, the signal-transducing receptor component of the IL6 receptor, act synergistic for the ex-vivo expansion of multipotential hematopoietic progenitors. A similar synergistic effect has been demonstrated for signalings from c-kit, c-mpl, and flt3. While c-kit is activated by stem cell factor (SCF), gpl30 can be activated by the complex of soluble IL-6 receptor (sIL-6R) and interleukin-6 (IL-6). Recently, a bioactive designer cytokine, H-IL-6, a fusion protein consisting of SIL-6R and IL-6 linked by a flexible peptide chain has been shown to expand human hematopoietic colony-forming cells. We tested the activity of H-IL-6 alone and in comb…