Search results for "ALIM"
showing 10 items of 1991 documents
Differential effects of potassium channel blockers on neurohypophysial release of oxytocin and vasopressin. Evidence for frequency-dependent interact…
1988
Isolated rat neurohypophyses were fixed by their stalks to a platinum wire electrode and superfused with Krebs-HEPES solution. Vasopressin and oxytocin released into the medium were determined by specific radioimmunoassays. Hormone secretion was increased by electrical stimulation of the pituitary stalk at different frequencies. The effects of several potassium channel blockers, tetraethylammonium (TEA) ions, 4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP) were tested. The release of vasopressin and oxytocin evoked by electrical stimulation with 900 pulses at 15 Hz (about 900 and 1,000 μU, respectively) was about 10 times higher than that evoked by 900 pulses at 3 Hz. Both 10 and 3…
Evidence for a 'window of opportunity' in hidradenitis suppurativa treated with adalimumab: a retrospective, real-life multicentre cohort study
2021
BACKGROUND The anti-tumour necrosis factor (TNF)-α adalimumab is the only licenced biologic for moderate-to-severe hidradenitis suppurativa (HS). No predictors of response have been identified so far. OBJECTIVES To identify clinical parameters predicting response to adalimumab and confirm its efficacy/safety. METHODS The data of 389 patients with HS treated with adalimumab in 21 Italian centres were reviewed. Sex, age at onset/diagnosis/baseline, body mass index, smoking, phenotype, previous treatments, concomitant antibiotics and 'therapeutic delay', defined as the time from HS onset to adalimumab initiation, were assessed. Response to adalimumab and its impact on quality of life (QoL) wer…
Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell
2015
AbstractTaste receptors on enteroendocrine cells sense nutrients and transmit signals that control gut hormone release. This study aimed to investigate the amino acid (AA) sensing mechanisms of the ghrelin cell in a gastric ghrelinoma cell line, tissue segments and mice. Peptone and specific classes of amino acids stimulate ghrelin secretion in the ghrelinoma cell line. Sensing of L-Phe occurs via the CaSR, monosodium glutamate via the TAS1R1-TAS1R3 while L-Ala and peptone act via 2 different amino acid taste receptors: CaSR & TAS1R1-TAS1R3 and CaSR & GPRC6A, respectively. The stimulatory effect of peptone on ghrelin release was mimicked ex vivo in gastric but not in jejunal tissue …
AB0467 EFFECTIVENESS OF GOLIMUMAB AFTER TNF-INHIBITOR FAILURE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS, OR AXIAL SPONDYLOART…
2021
Background:Golimumab showed trial efficacy in subjects with active rheumatoid arthritis (RA) previously treated with TNF-inhibitors (TNFi); no trial data are available for psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).Objectives:To assess the effectiveness of golimumab after TNFi failure in patients with RA, PsA, or axSpA in a real-world setting.Methods:GO-BEYOND-Italy is an ongoing, multicenter, prospective, observational study of RA, PsA, or axSpA patients starting golimumab after TNFi failure. Patients were enrolled between July 2017 and December 2019, and followed for 1 year, with evaluations at 3, 6, and 12 months. This interim analysis estimates the effectiveness after…
Encapsulation of Vitamins A and E as Spray-Dried Additives for the Feed Industry
2020
Encapsulated fat-soluble powders containing vitamin A (VA) and E (VE) were prepared as a feasible additive for extruded feed products. The effect of the encapsulating agents (Capsul-CAP®
Gli scambi marittimi dei prodotti agroalimentari nel Bacino del Mediterraneo: il ruolo della Sicilia
2012
This work shows the results of a survey on trade flows to agri-food products between Sicily and the non-EU countries of the Union for the Mediterranean, through maritime transport. The aim of the work is to outline the role that Sicily plays in respect of trade in agricultural products through the maritime mode considering its strategic location in the Mediterranean basin. Political reference scenario is that of the Union for the Mediterranean and EU Mediterranean Transport Policy (motorways of the sea). This work contains an analysis of the evolution of maritime trade in agri-food of Sicily, in the main ports of departure and arrival, with non-EU countries of the Union for the Mediterranea…
Il cibo per via. Paesaggi alimentari in Sicilia
2011
Il contributo di S. Bonanzinga esamina quel particolare aspetto del “cibo per via” che investe l’uso della voce da parte dei venditori. Le formule cadenzate che invitano all’acquisto degli alimenti non solo confermano il ruolo centrale degli uomini come gestori della dimensione pubblica, in opposizione a quello privato delle donne, ma perpetuano anche l’arcaica connessione fra suono e cibo come espressioni dell’energia naturale. Un potere della voce di modellare il reale che implode quello degli alimenti, messi in scena entro quelle cornici sonore di antica e più recente fattura che i siciliani chiamiano abbanniati, vanniati, bbanniati o bbanniatini. Le grida di réclame continuano a proporr…
La selta del biologico tra crisi economica e crisi alimentare: il caso del mercato di Palermo
2009
Abstract A partire dalla seconda metà del 2008 la crisi finanziaria che ha colpito l’economia mondiale, ha determinato la stagnazione dei consumi alimentari e un cambiamento nel comportamento di acquisto dei consumatori. La preoccupazione per il futuro e la riduzione del reddito disponibile, che limita la capacità di acquisto delle famiglie, hanno determinato variazioni sulla spesa alimentare in relazione sia ai quantitativi che alla composizione del paniere. Alla preoccupazione per la crisi economica, si accompagna quella per la contaminazione dei cibi causata dal susseguirsi nel tempo di numerosi scandali alimentari (mucca pazza, influenza aviaria, melamina nel latte cinese, formaggi cont…
The Italian Society of Gastroenterology (SIGE) and the Italian Group for the study of Inflammatory Bowel Disease (IG-IBD) Clinical Practice Guideline…
2010
Biological therapies are an important step in the management of Inflammatory Bowel Diseases. In consideration of high cost and safety issues there is the need to have clear recommendations for their use. Despite the American Gastroenterological Association and the European Crohn's and Colitis Organisation have published exhaustive Inflammatory Bowel Disease guidelines, national guidelines may be necessary as cultural values, economical and legal issues may differ between countries. For these reasons the Italian Society of Gastroenterology and the Italian Group for the study of Inflammatory Bowel Disease have decided to elaborate the Italian guidelines on the use of biologics in Inflammatory…
Estrategias de funcionalización alternativas de la micotoxina alternariol y desarrollo de métodos inmunoquímicos para el análisis rápido de alimentos
2023
El alternariol es un metabolito secundario producido por hongos del género Alternaria que se puede encontrar a concentraciones relativamente altas (μg/kg) en numerosos alimentos de origen vegetal. Debido a su toxicidad, con efectos mutagénicos y carcinogénicos demostrados, está considerado una amenaza emergente para la salud animal y humana. Por estos motivos, la Autoridad Europea de Seguridad Alimentaria (EFSA) ha establecido límites máximos tolerables de ingesta diaria de esta micotoxina y recomienda la realización de más estudios y controles en alimentos, particularmente en aquellos destinados al consumo infantil. En consecuencia, se requieren métodos de análisis que permitan la determin…