Search results for "ALIMTA"

CISPLATIN (C) AND ALIMTA (A) WITH PANITUMUMAB FOR ADVANCED NON-SQUAMOUS NON-SMALL CELL LUNG CANCER (NS-NSCLC): A PHASE I-DOSE FINDING STUDY.

2012

Background The treatment of NSCLC is rapidly changing since new drugs are becoming available. Recently, CA has become a standard for the first line treatment of NS-NSCLC. Previous clinical studies have shown that anti-EGFR MoAb may be added to chemotherapy, but the identification of a molecular signature can predict their activity and better define their true role. Aims In absence of data about the MTD of Panitumumab (a MoAb targeting the EGFR, potentially active in NS-NSCLC) when associated to chemotherapy, we decided to assess the optimal dose of panitumumab in combination with CA. Moreover, in view of a future phase II study, all pts will be studied for the following molecular characteri…