Search results for "ALK"

Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycl…

2009

Background The prevalence of and risk factors for central nervous system recurrence in patients with acute promyelocytic leukemia are not well established and remain a controversial matter. Design and Methods Between 1996 and 2005, 739 patients with newly diagnosed acute promyelocytic leukemia enrolled in two consecutive trials (PETHEMA LPA96 and LPA99) received induction therapy-with all-trans retinoic acid and idarubicin. Consolidation therapy comprised three courses of anthracycline monochemotherapy (LPA96), with all-trans retinoic acid and reinforced doses of idarubicin in patients with an intermediate or high risk of relapse (LPA99). Central nervous system prophylaxis was not given. Re…

Quantum Walk and Wigner function on a lattice

2014

201 páginas. Tesis Doctoral del Departamento de Física Teórica de la Universidad de Valencia y del Instituto de Física Corpuscular (IFIC).

Gradient flows in random walk spaces

2021

El món digital ha comportat l'aparició de molts tipus de dades, de mida i complexitat creixents. De fet, els dispositius moderns ens permeten obtenir fàcilment imatges de major resolució, així com recopilar dades sobre cerques a la xarxa, anàlisis sanitàries, xarxes socials, sistemes d'informació geogràfica, etc. En conseqüència, l'estudi i el tractament d'aquests grans conjunts de dades té un gran interès i valor. En aquest sentit, els grafs ponderats proporcionen un espai de treball natural i flexible on representar les dades. En aquest context, un vèrtex representa una dada concreta i a cada aresta se li assigna un pes segons alguna mesura de semblança adequadament triada entre els vèrte…

Lavtemperatur brenselceller

2005

Dokumentet er en del av en eksamensoppgave i MEF4200 Energimaterialer ved UiO høsten 2004. Som del av eksamen i emnet MEF4200 Energimaterialer ved Universitetet i Oslo (UiO) høsten 2004 var oppgaven å skrive en populærvitenskapelig artikkel for avgangselever i videregående skole. Artikkelen presenteres her og omhandler lavtemperatur brenselceller. De brenselcelletypene som beskrives er alkaliske brenselceller, PEM-brenselceller og metanolbrenselceller, alle med en driftstemperatur på normalt under 100 °C, og deres bruksområder.

ALK and crizotinib: After the honeymoon...what else? Resistance mechanisms and new therapies to overcome it

2014

The last few decades have witnessed a silent revolution in the war against NSCLC, thanks to the discovery of “oncogenic drivers” and the subsequent development of targeted therapies. The discovery of the EML4-ALK fusion gene in a subgroup of patients with NSCLC and the subsequent clinical development of crizotinib has been an amazing success story in lung cancer translational-research, and its accelerated approval [only 4 years from the discovery of ALK rearrangement in NSCLC to the approval by the Food and Drug Administration (FDA)] marked the beginning of the new decade of targeted therapy. However, common to all targeted therapies, despite an initial benefit, patients inevitably experien…

Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristal…

2007

Cannabinoid-1 (CB1) receptor activation affects gastrointestinal propulsion in vivo. It was our aim to further characterize the involved myenteric mechanisms in vivo and in vitro. In CB1(-/-) mice and wild-type littermates we performed in vivo transit experiments by charcoal feeding and in vitro electrophysiological recordings in mouse small intestinal smooth muscle. Ascending neuronal contraction (ANC) following electrical field stimulation was studied in rat ileum in a partitioned organ bath separating the aboral stimulation site from the oral recording site. The knockout animals displayed an accelerated upper gastrointestinal transit compared to control animals. The CB1 receptor antagoni…

BIS-INDOLYL-5-MEMBER HETEROCYCLES ANALOGUES OF MARINE ALKALOID NORTOPSENTIN: SYNTHESES AND ANTINEOPLASTIC ACTIVITY

2008

Random allogeneic blood transfusion in pigs: characterisation of a novel experimental model.

2019

BackgroundOrgan cross-talk describes interactions between a primary affected organ and a secondarily injured remote organ, particularly in lung-brain interactions. A common theory is the systemic distribution of inflammatory mediators that are released by the affected organ and transferred through the bloodstream. The present study characterises the baseline immunogenic effects of a novel experimental model of random allogeneic blood transfusion in pigs designed to analyse the role of the bloodstream in organ cross-talk.MethodsAfter approval of the State and Institutional Animal Care Committee, 20 anesthetized pig were randomized in a donor and an acceptor (eachn = 8): the acceptor animals …

Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens.

2015

Multidrug resistance (MDR) caused by human ABCB1 (P-glycoprotein/MDR1) is one of the major obstacles in chemotherapy. To understand the mechanism of MDR by ABCB1 and circumvent the MDR, in the present study, we established human ABCB1-expressing cells (Flp-In-293/ABCB1 cells) and examined the cytotoxic effects of four guanidine alkaloids from Pterogyne nitens (galegine, nitensidine A, pterogynidine and pterogynine) using Flp-In-293/Mock and Flp-In-293/ABCB1 cells. The activity of ABCB1 in Flp-In-293/ABCB1 cells were confirmed by typical substrates for ABCB1 (taxol and vinblastine) in MTT assay. Flp-In-293/ABCB1 cells were also resistant to the four guanidine alkaloids as well as taxol and v…

Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1.

2014

The Pterogyne nitens (Fabaceae) tree, native to South America, has been found to produce guanidine alkaloids as well as bioactive flavonols such as kaempferol, quercetin, and rutin. In the present study, we examined the possibility of interaction between human ATP-binding cassette (ABC) transporter ABCB1 and four guanidine alkaloids isolated from P. nitens (i.e., galegine, nitensidine A, pterogynidine, and pterogynine) using human T cell lymphoblast-like leukemia cell line CCRF-CEM and its multi-drug resistant (MDR) counterpart CEM/ADR5000. In XTT assays, CEM/ADR5000 cells were resistant to the four guanidine alkaloids compared to CCRF-CEM cells, although the four guanidine alkaloids exhibi…