Search results for "ALP"
showing 10 items of 4575 documents
α-decay spectroscopy of the N = 130 isotones 218Ra and 220Th: Mitigation of α-particle energy summing with implanted nuclei
2019
An analysis technique has been developed in order to mitigate energy summing due to sequential short-lived α decays from nuclei implanted into a silicon detector. Using this technique, α-decay spectroscopy of the N=130 isotones 218Ra (Z=88) and 220Th (Z=90) has been performed. The energies of the α particles emitted in the 218Ra→214Rn and 220Th→216Ra ground-state-to-ground-state decays have been measured to be 8381(4) keV and 8818(13) keV, respectively. The half-lives of the ground states of 218Ra and 220Th have been measured to be 25.99(10) μs and 10.4(4) μs, respectively. The half-lives of the ground states of the α-decay daughters, 214Rn and 216Ra, have been measured to be 259(3) ns and …
Spectroscopic studies of 173Pt and 175Pt
2014
Effect of SGLT-2 inhibition in abdominal aortic aneurysm development. Role of RORa in adipose tissue inflammation associated to obesity
2021
El aneurisma aórtico abdominal (AAA) se define como una dilatación local de la arteria aorta a nivel abdominal cuya consecuencia más grave es su ruptura si no se detiene su crecimiento y progresión. Los rasgos patológicos del AAA incluyen un estado inflamatorio crónico que afecta a la pared vascular de la aorta, una degradación progresiva de la matriz extracelular y un aumento en la neovascularización. Esta enfermedad presenta una elevada tasa de mortalidad y en la actualidad el único tratamiento efectivo que se conoce es la intervención quirúrgica, pero no está indicada en pacientes asintomáticos o que presentan un aneurisma de reducido tamaño. Por ello, es fundamental encontrar nuevas est…
Bel-Air, Sénas (Bouches-du-Rhône) : a Late Neolithic open-air settlement site on the eastern foot-slopes of the Massif des Alpilles. Preliminary resu…
2014
This article is the first presentation of the excavation results following the developer-led archaeological project carried out between July and August 2012 at the site of Bel-Air, Sénas, Bouches-du-Rhône. Our current understanding of the diverse archaeological remains show that a densely occupied settlement existed within a relatively short-lived period during the second phase of the Late Neolithic in Provence, between 2880 and 2490 BC. The occupation is characterised by several phases of activity, which are at this stage of research, difficult to refine, but all of them being associated with the Couronnien group.
Visuaalisen palautteen vaikutus fysioterapiaopiskelijoiden palpaatiotaitojen tarkkuuteen lonkan alueen lihaksistossa : satunnaistettu kontrolloitu tu…
2012
Nopeasta teknologisesta kehityksestä huolimatta manuaalisen tutkimisen taidot ovat edelleen tärkeä ydinosaamisalue fysioterapiassa. Manuaalisessa tutkimisessa eniten käytetty tekniikka on palpaatio, joka käsin toteutettavana tutkimisen tekniikkana tukee hoitopäätöksen tekemistä ja ohjaa näin hoidon tuloksellisuutta. Palpaatio on toimenpiteenä nopea ja halpa, mutta sen haasteena ovat subjektiivisuus ja objektiivisen standardin puute. Palpaation tarkkuudessa ja toistettavuudessa onkin havaittu puutteita. Palpaatiotaitoa on perinteisesti opetettu anatomisiin piirroksiin, kuviin ja anatomisiin luu- ja lihasmalleihin sekä kinesteettisen aistin antamaan palautteeseen nojaten. Tutkimustieto on kui…
Benson group additivity values of phosphines and phosphine oxides: Fast and accurate computational thermochemistry of organophosphorus species
2018
Composite quantum chemical methods W1X-1 and CBS-QB3 are used to calculate the gas phase standard enthalpy of formation, entropy, and heat capacity of 38 phosphines and phosphine oxides for which reliable experimental thermochemical information is limited or simply nonexistent. For alkyl phosphines and phosphine oxides, the W1X-1, and CBS-QB3 results are mutually consistent and in excellent agreement with available G3X values and empirical data. In the case of aryl-substituted species, different computational methods show more variation, with G3X enthalpies being furthest from experimental values. The calculated thermochemical data are subsequently used to determine Benson group additivity …
Direct P-functionalization of azobenzene by a cationic phosphidozirconocene complex.
2016
International audience; We report that the cationic phosphidozirconocene complex [(eta(5)-C5H5)(2)Zr(PCy2)][CH3B(C6F5)(3)] (II) reacts with azobenzene, resulting in the expedient formation of Zr complex (2) bound to a tridentate PNN ligand. This reaction proceeds by a mechanism of cooperative nucleophilic substitution of hydrogen. The intermediate sigma(H) adduct (1) has been characterized by NMR spectroscopy.
A novel intrinsically disordered outer membrane lipoprotein ofAggregatibacter actinomycetemcomitansbinds various cytokines and plays a role in biofil…
2017
Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin receptor I (BilRI) of the opportunistic oral pathogen Aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (IL)-1b. Because the amino acid sequence of the novel lipoprotein resembles that of fibrinogen binder A of Haemophilus ducreyi, BilRI could have the potential to bind other proteins, such as host matrix proteins. However, from th…
Oxymetazoline modulates proinflammatory cytokines and the T‐cell stimulatory capacity of dendritic cells
2007
The nasal decongestant oxymetazoline (OMZ) is frequently used in the topical treatment of rhinitis/sinusitis. As proinflammatory cytokines play a critical role in the development and maintenance of local inflammation, the aim of this study was to investigate the influence of OMZ on immune cells in order to diminish the mucosal infiltration of the nose. Peripheral blood mononuclear cells (PBMC) from buffy coats of healthy volunteers were isolated and stimulated in the presence or absence of OMZ. In addition, monocyte-derived dendritic cells (DC) were generated and different concentrations of OMZ were added. DC phenotype and their T-cell stimulatory properties were analysed. The vasoactive su…
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.
2005
Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …