Search results for "ALTER"
showing 10 items of 2368 documents
Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets
2020
Autosomal recessive mutations in genes required for cytotoxicity are causative of a life-threatening, early-onset hyperinflammatory syndrome termed familial hemophagocytic lymphohistiocytosis (FHL). Mutations in UNC13D cause FHL type 3. UNC13D encodes Munc13-4, a member of the Unc13 protein family which control SNARE complex formation and vesicle fusion. We have previously identified FHL3-associated mutations in the first intron of UNC13D which control transcription from an alternative transcriptional start site. Using isoform specific antibodies, we demonstrate that this alternative Munc13-4 isoform with a unique N-terminus is preferentially expressed in human lymphocytes and platelets, as…
Subject case alternation in negated existential, locative, and possessive clauses in Latvian
2018
[full article and abstract in English]
 The goal of this article is to analyse the alternation between the genitive and nominative cases in Latvian. As the alternation between genitive and nominative cases is possible in all clauses in which the verb būt ‘to be’ is used as an independent verb, this article examines existential, locative, and also possessive clauses, while also demonstrating that distinguishing these clause types is problematic for Latvian utilising the criteria given in the linguistic literature. Clauses containing the negative form of būt ‘to be’, i.e. nebūt, form the foundation of those selected for this study, as only in these sentences the genitive/nominative alter…
Neologia i gramàtica: entre el neologisme lèxic i el neologisme sintàctic
2015
Resum: En aquest treball es mira de contribuir a objectivar el concepte de neologia sintàctica, de manera que pugui ser un recurs classificatori operatiu. La proposta és utilitzar l’expressió neologisme sintàctic per referir-nos als canvis de règim verbal que no són concomitants amb canvis semàntics (ja que llavors haurem de parlar de neologisme semàntic), i que tampoc concorren amb altres procediments neològics. En aquest sentit, un neologisme sintàctic no és un neologisme lèxic, una paraula nova, com sí que ho són els neologismes semàntics. Quan diem que el neologisme sintàctic exclou el canvi semàntic, però, no ens referim al significat relacionat amb les propietats estructurals de tipus…
Metabarcoding Analysis of Fungal Diversity in the Phyllosphere and Carposphere of Olive (Olea europaea)
2015
The fungal diversity associated with leaves, flowers and fruits of olive (Olea europaea) was investigated in different phenological stages (May, June, October and December) using an implemented metabarcoding approach. It consisted of the 454 pyrosequencing of the fungal ITS2 region and the subsequent phylogenetic analysis of relevant genera along with validated reference sequences. Most sequences were identified up to the species level or were associated with a restricted number of related taxa enabling supported speculations regarding their biological role. Analyses revealed a rich fungal community with 195 different OTUs. Ascomycota was the dominating phyla representing 93.6% of the total…
‘bien entendu’ vs ‘naturellement’: deux façons de désubjectiviser le dire
2011
Our study focuses on how the discourse markers (DM) participate in the construction of discursive alterity. In our approach, the DM builds, for an assertion, a guarantor with its own semantics, which is the semantics of the lexical element constituting the basis of DM. Naturellement and bien entendu build referential value which ”disempowers” the speaker as a guarantor of his words. This desubjectivation is realized differently in each case analyzed, and is determined by the semantic identity of the DM. In this article we analyze how the DM build modulated commitment of the speaker in his role as the guarantor, convened by the semantics of the DM in the ”disresponsibilization” of the speake…
Artemisinin–Second Career as Anticancer Drug?
2015
Artemisinin represents a showcase example not only for the activity of medicinal herbs deriving from traditional chinese medicine, but for phytotherapy in general. Its isolation from Sweet Wormwood (qinhao, Artemisia annua L.) represents the starting point for an unprecedent success story in the treatment of malaria worldwide. Beyond the therapeutic value against Plasmodium parasites, it turned out in recent years that the bioactivity of artemisinin is not restricted to malaria. We and others found that this sesquiterpenoid also exerts profound anticancer activity in vitro and in vivo. Artemisinin-type drugs exert multi-factorial cellular and molecular actions in cancer cells. Ferrous iron …
Mediation for resolving family disputes
2016
Nowadays the understanding of the institute of marriage and its importance in the society has changed. Marriage is no longer assumed to be a commitment for a lifetime. As the principle of equality has replaced hierarchy as the guiding principle of family law it gave more grounds for family disputes and it became socially acceptable to leave marriages that are intolerable or merely unfulfilling. The aim of this article is to suggest an alternative dispute resolution method-mediation as a worthy option for resolving family conflicts.
Dictamen profesional sobre la fusión y escisión como extrategias alternativas en un grupo de sociedades
2021
This work is a professional, legal opinion which sets out two alternative strategies (merger by absorption and partial demerger) in order to bring together the different areas of activity of the various companies in a group of companies. The aim is to provide solutions to the questions raised by customers and, therefore, to set out clearly and simply the procedure to be followed in each of the strategies, weighing up the advantages and disadvantages from each of them
Donne autrici o vittime di reato? Un’indagine sull’efficacia delle misure alternative nei percorsi di recupero delle detenute nel contesto agrigentino
2015
Nel senso comune la pena detentiva e considerata un elemento inevitabile della so¬cieta contemporanea. Essa continua ad essere percepita nell’immaginario collettivo come uno strumento di segregazione per coloro che sono riconosciuti colpevoli di particolari reati. I principi classici della prontezza, proporzionalita, infallibilita e dolcezza della pena non si identificano oggi esclusivamente con un edificio – la prigione – ma, sempre piu di frequente, con strumenti alternativi e piu efficaci per il recupero e la risocializzazione del soggetto. Proprio in questi decenni in cui l’intreccio fra poverta, penalita ed esclusione sociale diviene sempre piu evidente, l’afflizione a cui il singolo e…
Developments in the evolutionary theory of social interactions
2016
Altruistic behaviour, which benefits others but harms the actor, can evolve when copies of the underlying genes are transmitted to future generations by related beneficiaries. While we know that the mechanism of ‘kin selection’ answers to how altruism can evolve, the answers to why and when it can evolve are still obscure. The first aim of this thesis is to shed light to the evolution of altruism by identifying factors that facilitate or promote it. I find that the conditions under which altruism can evolve follow surprisingly simple principles that are independent of the taxon-specific traits such as fecundity. Further, by analysing the unique aspects of haplodiploid sex determination syst…