Search results for "ALTER"
showing 10 items of 2368 documents
Calcium Dependence of the Mechanical Response Evoked by Okadaic Acid in Smooth Muscle
1995
The effects of okadaic acid (OA), obtained from a culture of the marine dinoflagellate Prorocentrum Lima were studied on isolated strips of rat myometrium. The contractile response evoked by OA at 5, 10, and 20 μM in normal physiological solution was unaffected in the presence of tetrodotoxin (10 μM), indomethacin (3 μM), or a cocktail of antagonists which blocked muscarinic, adrenergic, histaminergic, serotonergic, and opioid receptors. Similarly, the response to OA was unaffected in the presence of nifedipine at a concentration (1 μM) which completely or highly blocked the response to KCl (60 mM), oxytocin (1 μM), or acetylcholine (100 μM). In a Ca 2+ -free 1 mM EGTA-containing solution, …
Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: a randomized, double-blind, placebo-controlled trial.
2011
Crataegus laevigata is a medicinal plant most commonly used for the treatment of heart failure and psychosomatic disorders. Based on previous experimental findings, this double-blind placebo-controlled study was aimed at finding beneficial effects of C. laevigata on biomarkers of coronary heart disease (CHD). The study included 49 diabetic subjects with chronic CHD who were randomly assigned to the treatment for 6 months with either a micronized flower and leaf preparation of C. laevigata (400 mg three times a day) or a matching placebo. Blood cell count, lipid profile, C-reactive protein, neutrophil elastase (NE) and malondialdehyde were analyzed in plasma at baseline, at one month and six…
Translational Research for Improving the Care of Familial Hypercholesterolemia: The “Ten Countries Study” and Beyond
2016
Familial hypercholesterolemia (FH) is the most common and serious form of inherited hyperlipidaemia. Dominantly inherited with high penetrance, untreated FH leads to premature death from coronary artery disease due to accelerated atherosclerosis from birth. Despite its importance, there is still a major shortfall in awareness, detection and treatment of FH worldwide. International models of care for FH have recently been published, but their effective implementation requires the garnering of more knowledge about the condition. The "Ten Countries Study" aims to investigate diagnostic, epidemiological and service aspects, as well as physician practices and patient experiences of FH in several…
Å være pårørende når alternativ behandling tas i bruk i “kampen mot kreft”
2015
<strong>Being relatives when alternative therapies are used in the "fight against cancer"</strong><br />CAM (Complementary and Alternative Medicine) is prevalent among cancer patients. Relatives are central to support and care for the patient but experience challenges and stresses in this role. The purpose of this study was to gain knowledge of how it is experienced to be relative of people with terminal cancer who seeks CAM. Five qualitative semi-structured in-depth interviews of relatives and nine biographies written by relatives were analyzed using systematic text condensation. Results showed that relatives experienced to fight for hope in a given battle, not knowing wh…
The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal
2014
Despite their widespread use, long-acting injectable (LAI) antipsychotics (APs) are often regarded with some negativity because of the assumption of punishment, control and insufficient evolution towards psychosocial development of patients. However, LAI APs have proved effective in schizophrenia and other severe psychotic disorders because they assure stable blood levels, leading to a reduction of the risk of relapse. Therapeutic opportunities have also arisen after introduction of newer, second-generation LAI APs in recent years. Newer LAI APs are more readily dosed optimally, may be better tolerated and are better suited to integrated rehabilitation programmes. This review outlines the …
Alternative methods of mechanical Cardiopulmonary Resuscitation
2000
Due to the relative ineffectiveness of standard resuscitation techniques, alternative methods have been explored for many years. The aim of new methods is to improve haemodynamics and increase survival rates. In spite of some encouraging haemodynamic results, all but one study failed to show an increase in long-term survival rates with an alternative method in a convincingly large group of patients (hospital discharge without neurological damage, and 1-year survival). In this study active compression-decompression resuscitation (ACD-CPR) increased long-term survival compared to standard-CPR. The results from certain individual studies, which showed a significant increase in short-term survi…
Geschlecht und Gender in der Medizin
2005
Gender specific medicine is a part of gender-research, which has been insufficiently considered up to the present in medicine, sanitation and politics. Part of the scientific medicine simply ignores the knowledge that menand women are different in feeling, thinking and social acting without any question. Doctors often incline to treat all their patients as if there was just one gender: i. e. the male one. It is without dispute that men and women vastly suffer from the same diseases, but they often go through them quite differently. The female body seems to work differently from the male one in nearly all respects - starting with the brain, going on with the heart, cardiovascular, lungs, sto…
Education for Health Back at School Age: The Role of Physical Education
2015
Traditionally, back problems have been addressed from the biomedical area. For a long time the "radiologic-anatomy model" has been considered unusable because they have failed to respond to knowledge about the source of pain or therapeutic approaches used have solved the reduced chronic pain or disability [1]. In this way, it was like the biomedical reductionist approach was replaced by the "biopsychosocial model" [1] which proposes that psychological and social factors along with biological variables in understanding a person's disease are included.
Online Adaptation to Altered Auditory Feedback Is Predicted by Auditory Acuity and Not by Domain-General Executive Control Resources
2018
Published: 12 March 2018 When a speaker's auditory feedback is altered, he adapts for the perturbation by altering his own production, which demonstrates the role of auditory feedback in speech motor control. In the present study, we explored the role of auditory acuity and executive control in this process. Based on the DIVA model and the major cognitive control models, we expected that higher auditory acuity, and better executive control skills would predict larger adaptation to the alteration. Thirty-six Spanish native speakers performed an altered auditory feedback experiment, executive control (numerical Stroop, Simon and Flanker) tasks, and auditory acuity tasks (loudness, pitch, and …
Estudio presurométrico y biomecánico del pie en el pádel
2014
[EN] Padel is a very popular sport in countries like Spain, Argentina and Brazil, but there is a lack of scientific papers analyzing the harmfulness of their practice. Padel movements could potentially damage the foot and ankle joint. Therefore, the objective of this study was the characterization of the foot role during the execution of the most representative padel movements by techniques of pressurometry and video. The study was divided in two parts: pressurometric analysis of two movements (head-on displacement and split-step), and video recording of the foot during two games. The main conclusions of the study are the importance of forefoot zone in the padel movements, the importance of…