Search results for "ALTER"
showing 10 items of 2368 documents
Ochrona praw mniejszości narodowych i etnicznych na tle zmian politycznych w Polsce - przyczynek do dyskusji
2021
Polskie prawo posiada bogaty zestaw narzędzi ochrony praw i wsparcia mniejszości narodowych i etnicznych, na czele z art. 35 Konstytucji RP i ustawą z 6 stycznia 2005 r. o mniejszościach narodowych i etnicznych i o języku regionalnym. Kilkanaście lat funkcjonowania ustawy jest odpowiednio długim okresem, by móc oceniać skuteczność i funkcjonalność systemu ochrony i wsparcia tych społeczności oraz zastanawiać się nad ewolucją polityki na ich rzecz, realizowaną przez poszczególne rządy. Spośród polskich mniejszości narodowych i etnicznych najliczniejszą i najlepiej zorganizowaną jest mniejszość niemiecka, zamieszkująca głównie obszar województwa opolskiego. Społeczność ta ma potencjał, by w p…
Structural and functional salivary disorders in type 2 diabetic patients
2006
La diabetes mellitus tipo 2 es el desorden metabólico más frecuente, siendo además causante de una importante morbi-mortalidad. En estos pacientes se han descrito alteraciones estructurales de la parotida (sialosis) que podrían comportar modificaciones en la composición salivar, así como un incremento de patología dental y periodontal. Objetivos: establecer las alteraciones bioquímicas de la saliva y su posible correlación con los hallazgos morfológicos. Diseño del estudio: se realizo un estudio clínico de 33 pacientes, 17 de ellos con diabetes tipo 2. Se recogieron muestras de saliva para análisis bioquímico y suero para control metabólico. Resultados: en la saliva de los pacientes diabéti…
Alteraciones salivares en pacientes con diabetes tipo 2
2006
La diabetes mellitus tipo 2 es el desorden metabólico más frecuente, siendo además causante de una importante morbi-mortalidad. En estos pacientes se han descrito alteraciones estructurales de la parotida (sialosis) que podrían comportar modificaciones en la composición salivar, así como un incremento de patología dental y periodontal. Objetivos: establecer las alteraciones bioquímicas de la saliva y su posible correlación con los hallazgos morfológicos. Diseño del estudio: se realizo un estudio clínico de 33 pacientes, 17 de ellos con diabetes tipo 2. Se recogieron muestras de saliva para análisis bioquímico y suero para control metabólico. Resultados: en la saliva de los pacientes diabéti…
Standardisation of methods for assessing mould germination: a workshop report.
2006
International audience; The first workshop on predictive mycology was held in Marseille, France, 2–4 February 2005 under the auspices of the French Microbiological Society. The purpose of the workshop was to list the different techniques and definitions used by scientists for assessing mould germination and to evaluate the influence of the different techniques on the experimental results. Recommendations were made when a large consensus was obtained. In order to facilitate the study of germination, alternative methods to microscopic examination were examined.
Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development.
2015
International audience; Myotonic dystrophy type 1 (DM1) is caused by an unstable expanded CTG repeat located within the DMPK gene 3'UTR. The nature, severity and age at onset of DM1 symptoms are very variable in patients. Different forms of the disease are described, among which the congenital form (CDM) is the most severe. Molecular mechanisms of DM1 are well characterized for the adult form and involve accumulation of mutant DMPK RNA forming foci in the nucleus. These RNA foci sequester proteins from the MBNL family and deregulate CELF proteins. These proteins are involved in many cellular mechanisms such as alternative splicing, transcriptional, translational and post-translational regul…
Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
2012
SummaryMyotonic dystrophy type 1 (DM1) is a genetic disease caused by the pathological expansion of a CTG trinucleotide repeat in the 3' UTR of the DMPK gene. In the DMPK transcripts, the CUG expansions sequester RNA-binding proteins into nuclear foci, including transcription factors and alternative splicing regulators such as MBNL1. MBNL1 sequestration has been associated with key features of DM1. However, the basis behind a number of molecular and histological alterations in DM1 remain unclear. To help identify new pathogenic components of the disease, we carried out a genetic screen using a Drosophila model of DM1 that expresses 480 interrupted CTG repeats, i(CTG)480, and a collection of…
Molecular Effects of the CTG Repeats in Mutant Dystrophia Myotonica Protein Kinase Gene
2008
Myotonic Dystrophy type 1 (DM1) is a multi-system disorder characterized by muscle wasting, myotonia, cardiac conduction defects, cataracts, and neuropsychological dysfunction. DM1 is caused by expansion of a CTG repeat in the 3 untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene. A body of work demonstrates that DMPK mRNAs containing abnormally expanded CUG repeats are toxic to several cell types. A core mechanism underlying symptoms of DM1 is that mutant DMPK RNA interferes with the developmentally regulated alternative splicing of defined pre-mRNAs. Expanded CUG repeats fold into ds(CUG) hairpins that sequester nuclear proteins including human Muscleblind-lik…
Acupuncture in the treatment of temporomandibular disorders, facial pain, and postural neuromuscular disorders. Presentation of a clinical case
2021
Abstract Background and objectives Temporomandibular disorders have a multifactorial etiology and involve the masticatory muscles, temporomandibular joint and associated structures. Therefore, different treatments are proposed and used. The aim of this paper is the use of acupuncture to treat temporomandibular disorders and associated symptoms. This article presents a clinical case study of a 39-year-old patient who presented temporomandibular disorders and headache of muscular origin. Results After 10 acupuncture sessions, the results were highly satisfactory, with complete relief of headache pain and absence of joint disorders. These results suggest the efficacy of acupuncture in the symp…
Rhythmic exercises as tools for rehabilitation following cerebellar stroke: A case study integrating music therapy and physiotherapy techniques
2022
Introduction: This article explores the use of music and multisensory stimuli in the construction of compensatory neural networks for motoric functioning in a patient recovering from cerebellar strokes (CS). This study aimed to address the real-world clinical concern of patients having a passive role in therapy, by arousing the client’s interest and self-motivation in rehabilitation. Method: The article presents a case study of a CS survivor, using data derived from rehabilitation sessions combining music therapy techniques with physiotherapy techniques to improve the fluency and accuracy of his motor performance. Qualitative and quantitative data are used to identify, describe, and evaluat…
La combustione HCCI mediante miscele di gas naturale e benzina: una prima esperienza sperimentale
2016
Si presentano in questo articolo i risultati di una sperimentazione volta a valutare la possibilità di effettuare una combustione HCCI (Homogeneous Charge Compression Ignition) stabile mediante l’impiego di miscele di gas naturale (GN) e benzina. La combustione HCCI ha ottime prerogative di basso impatto ambientale, ma la sua realizzazione pone qualche problema di stabilità al variare delle condizioni di carico richieste al motore: lo studio condotto mostra come l’impiego di miscele di GN e benzina, la cui composizione permette di variarne la resistenza all’autoaccensione, consente di ampliare il campo di funzionamento stabile della combustione HCCI. In the last decade the HCCI combustion h…